Neurocognitive Disorders and Grieving Flashcards
Delirium:
Definition:
Delirium is a state of acute confusion
and rapidly changing mental function. It is characterized
by an inability to focus attention
, changes in psychomotor activity, incoherent speech, disorientation, hallucinations, illusions, and an acute onset
over hours or days. Importantly, it is usually temporary,
and clinical features
may fluctuate throughout the day, often worsening at night.
Clinical Features:
-
Inability to Focus Attention:
Patients with delirium struggle to maintain attention and concentration.
-
Change in Psychomotor Activity: This
can manifest as either agitation or a slowed-down, lethargic state.
- Incoherent Speech: Speech may be disjointed, nonsensical, or difficult to follow.
-
Disorientation:
Patients
may beunaware of their surroundings,
time,or even their own identity.
-
Hallucinations
and Illusions: Perceptions may be altered, leading toseeing things that are not present.
-
Acute Onset: Delirium has a sudden and rapid onset,
some
othermental
healthconditions.
-
Fluctuating Course: Symptoms may vary in intensity and clarity throughout the day.
Worsens at night.
Etiology (Causes):
Delirium can be triggered by various underlying medical conditions. Some common causes include:
-
Systemic Infections:
- Example: Severe bacterial or viral infections, such as pneumonia or
urinary tract infections.
- Example: Severe bacterial or viral infections, such as pneumonia or
-
Fever:
- Example: High fever associated with an infection or inflammatory condition.
-
Endocrine Disorders:
- Example:
Pituitary
disorders
- Example:
-
Seizures:
- Example: Intense or recurrent seizures affecting the brain’s normal function.
-
Metabolic Disorders:
- Example:
Hypo/per/glycemia
( blood sugar: poorly controlled, can lead to vascular changes that affectblood flow to the brain
.) or hypoxia (inadequate oxygen supply to tissues).
- Example:
-
Trauma:
- Example: Physical trauma, such as a head injury, or psychological trauma.
-
Sensory or Sleep Deprivation:
- Example: Prolonged periods of
sensory isolation
orchronic lack of sleep.
- Example: Prolonged periods of
-
Substance Intoxication or Withdrawal:
- Example:
Delirium tremens (DT)
resulting fromalcohol withdrawal.
- Example:
-
Medications:
- Example: Adverse
reactions
to
certain medications, particularlyanticholinergic
drugs or certainpsychotropic
medications
.
- Example: Adverse
-
Electrolyte Imbalance:
- Example: Disturbances in
sodium
,potassium
, orcalcium
levels. They can fuck with the blood and the brain as well.
- Example: Disturbances in
-
Cerebrovascular Accidents (CVAs):
- Example:
Stroke
or other cerebrovascular events affecting blood flow to the brain.
- Example:
-
Brain Abscess:
- Example: A collection of
pus
within the brain tissue.
- Example: A collection of
-
Post-operative States:
- Example: Delirium that occurs after surgery, especially in elderly individuals.
Treatment:The primary goal in treating delirium is to identify and address the underlying cause.
This may involve medical interventions such as treating infections or adjusting medications. From a psychiatric standpoint:
- Patient Safety: Ensuring the safety of the patient is a top priority.
- Close Observation: Regular and close monitoring of the patient’s mental status is crucial.
-
Pharmacological Intervention:
If the patient becomes violent or poses a risk to themselves, medications may be used.
Commonly employed drugs includehaloperidol
(Haldol) and lorazepam (Ativan).
However, it’s essential to use these medications judiciously (with good judgment.), aspolypharmacy can exacerbate delirium.
Only use what is necessary for the patient’s safety.
Difference between dementia, depression (pseudodementia), and normal forgetting:
Normal Forgetting:Normal forgetting
is a part of the aging process
and is considered a typical aspect of cognitive function in older individuals.
Here are some key points:
- Onset and Progression: Recall processes begin to slow around age 40,
and this slowing continues as individuals age.
- Memory Function: While memory remains generally intact,
there is a decrease in the speed of information retrieval
. This can manifest as forgetfulness in daily life.
- Other Cognitive Aspects: There may be some decrease in attention span (فترة مدى duración), abstraction, and naming ability.
This is a natural consequence
of aging and the decrease in the efficiency of neuronal processing.
- Neuronal Changes: Aging involves a decrease in the number of neurons and a decline in their processing ability.
This contributes to the overall slowing of cognitive functions.
- Lifestyle Impact: There is increasing evidence that staying mentally and physically active can help slow the normal aging-related cognitive decline
. The phrase "use it or lose it"
encapsulates the idea that engaging in cognitive and physical activities can support cognitive function as people age
Dementia:
Latin word "dement," which means "out of one's mind" "خَرَف
Don’t confuse with delirium
Dementia is a broad term for a group of cognitive disorders characterized by a decline in memory and other cognitive abilities
that interfere with daily life. Here are some key distinctions:
- Onset and Progression: Dementia is not a normal part of aging.
It has a more insidious (خبيث)
onset and a progressive course.
- Memory Impairment: Unlike normal forgetting, dementia involves significant memory impairment that interferes with daily functioning.
It goes beyond occasional forgetfulness.
- Cognitive Decline: Dementia affects
various cognitive functions
, including memory, language, problem-solving, and executive function.
- Neuropsychiatric Symptoms: Dementia
often presents with
neuropsychiatric symptoms such as personality changes, mood swings, and behavioral issues.
- Irreversible: Most forms of dementia are progressive and irreversible, with Alzheimer's disease being the most common cause.
Depression (Pseudodementia):Depression can sometimes present with symptoms that mimic dementia,
a condition known as pseudodementia.
Here are some distinguishing features:
- Onset and Course: Pseudodementia often has a more sudden onset
, and its course is tied to the underlying depressive episode.
- Reversibility: Unlike most dementias, pseudodementia is reversible
with
appropriate treatment
of
the underlying depression
.
- Memory Impairment: Memory deficits in pseudodementia are typically more related to attention and concentration difficulties,
rather than the profound and widespread memory impairment seen in dementia.
- Mood Symptoms: Depression, including feelings of sadness, hopelessness, and a lack of interest or pleasure, is a prominent feature in pseudodementia.
Characteristics of depression in the elderly, sometimes referred to as “pseudodementia”:
Depression in the Elderly (“Pseudodementia
”):
- Prevalence: is relatively common in the elderly
population, and in some cases, it can present with symptoms that mimic dementia, leading to the term "pseudodementia."
- Global Slowing of Mental Processes: Individuals with pseudodementia
, especially in the elderly,
often experience
a general slowing of all mental processes. This can manifest as difficulties with concentration, attention, and overall cognitive function.
- Memory Complaints: Patients may complain of forgetfulness
, reflecting the cognitive impact of depression. However, it’s important to note that these memory complaints are often more related to difficulties with attention and concentration
rather than the profound and widespread memory impairment seen in true dementias.
- Preservation of Certain Cognitive Functions: Despite cognitive difficulties, aspects of cognitive function such as recall, spatial orientation, and recognition tend to remain mostly intact
in depression.
- Association with Stress or Loss: Depression in the elderly is often triggered
or exacerbated by stressors, such as the loss of a loved one, health issues, or other life changes.
- Physical Symptoms: Physical symptoms commonly associated with depression include a loss of appetite, decrease in overall activity levels, and a flat affect (reduced emotional expression).
- Diurnal Variation: Symptoms may show diurnal (daily in Latin
) variation, with some improvement as the day progresses.
This contrasts with the more consistent and progressive nature of many dementias.
- Social Behavior: Despite cognitive difficulties, individuals with depression
typically remain oriented to their surroundings and retain social inhibitions. They do not exhibit wandering behavior, which is sometimes seen in advanced dementia.
- Response to Treatment: One key feature that distinguishes pseudodementia from true dementia is the potential for improvement. Pseudodementia is reversible with appropriate treatment of the underlying depression, whereas most forms of dementia are progressive and irreversible.
Features of dementia, now categorized as Mild Neurocognitive Disorder or Major Neurocognitive Disorder in the DSM-5:
Dementia (Mild Neurocognitive Disorder or Major Neurocognitive Disorder):
-
Insight Diminishment:
Individuals with dementia
, especially as the illness progresses,may deny
or underestimatetheir mental impairment.
Insight
into
thecognitive decline
tends todiminish over time.
-
Memory Impairment: Memory impairment, especially in the form of
short-term memory loss, is a hallmark feature of dementia.
As the disease advances,individuals may struggle with recall, spatial orientation, and recognition of familiar faces or places.
-
Psychotic Symptoms:
Hallucinations are relatively rare in dementia,
and if present, they are typically not a prominent feature.Delusions, if present
, tend to be poorly structured andmay have paranoid themes.
-
Appetite:
Unlike depression, appetite is often intact in individuals with dementia.
-
Disorientation:
Disorientation
is acommon
featurein dementia,
andindividuals may become
lost evenin familiar environments.
Wandering
is a significant problem, posing safety concerns.
-
Emotional Lability and Agitation:
Dementia
oftenleads
to emotional lability
,(easily altered, "التقلب")
with individuals experiencing rapid and unpredictable changes in mood.Agitation
is acommon
behavioral manifestation, and it can bechallenging
for
bothindividuals with dementia and their caregivers.
-
Disinhibition: Individuals with dementia may display
disinhibited
behaviors, such asdisrobing in inappropriate settings
, as a result of impaired judgment and social awareness. -
Variability in Symptoms: The specific symptoms and their severity can vary widely depending on the type of dementia and the extent of the illness.
Alzheimer's disease, vascular dementia, Lewy body dementia, and other types of dementia may present with distinct clinical features.
Clinical Considerations of dementia:
Clinical Considerations:
- Progressive Nature: Dementia
is characterized by a progressive decline in cognitive function
, impacting daily life activities. It is not a reversible condition.
- Challenges in Communication: As dementia progresses, communication abilities
may decline
, making it challenging for individuals to express themselves or understand others.
- Caregiver Burden: Dementia places a significant burden on caregivers
due to the complex needs of individuals with the condition. It requires a comprehensive and compassionate approach to care.
- Multidisciplinary Approach: Management
of dementia often involves a multidisciplinary team
, including physicians
, nurses
, social workers, and therapists
, to address medical, psychological, and social aspects of the condition.
Most common types Neurocognitive disorders:
The term Alzheimer is named after Dr. Alois Alzheimer, a German psychiatrist and neuropathologist.
-
Alzheimer’s Disease:
-Alzheimer's
disease is themost prevalent cause of neurocognitive disorders.
It is a progressive brain
disorder characterized by theaccumulation
ofabnormal
protein
aggregates
, leading to memory loss, cognitive decline, and functional impairment.
Most common types Neurocognitive disorders:
Vascular Dementia
-
Vascular Dementia:
- Vascular dementia results fromimpaired blood flow to the brain,
often due to strokes
or other vascular issues. It is thesecond most common cause of neurocognitive disorders
and can lead to a range of cognitive impairments.
Most common types Neurocognitive disorders:
Lewy Body Dementia
-
Lewy Body Dementia:
- Lewy body dementia involves thepresence of abnormal protein deposits called Lewy bodies in the brain.
Itshares characteristics with both Alzheimer's and Parkinson's disease
and is associated withcognitive fluctuations, visual hallucinations, and motor symptoms.
Most common types Neurocognitive disorders:
Frontotemporal dementia
-
Frontotemporal Dementia:
- Frontotemporal dementia is characterized bydamage to the frontal and/or temporal lobes of the brain.
It often presents withchanges in personality, behavior, and language difficulties.
Most common types Neurocognitive disorders:
Parkinson’s Disease
-
Parkinson’s Disease:
- Parkinson’s disease is primarily amovement disorder
, but itcan
alsolead
tocognitive
decline
anddementia
inlater
stages
. The underlyingpathology involves the loss of dopamine-producing neurons.
Most common types Neurocognitive disorders:Traumatic Brain Injury (TBI)
- Traumatic Brain Injury (TBI):
- Neurocognitive disorders can result from traumatic brain injuries, which may occur due to accidents,
falls, or other forms of head trauma. The severity and type of cognitive impairment can vary depending on the extent of the injury.
Most common types Neurocognitive disorders:
Huntington’s disease
-
Huntington’s Disease:
- Huntington’s disease is agenetic
disorder that leads to progressivedegeneration
ofnerve cells
in thebrain
.
It is characterized by motor abnormalities, psychiatric symptoms, and cognitive decline.
Most common types Neurocognitive disorders:
Alcohol and Substance Abuse
-
Alcohol and Substance Abuse:
- Chronic alcohol and drug abuse can contribute to neurocognitive disorders. Prolonged substance abuse
can lead tostructural and functional brain changes
, resulting incognitive deficits.
Most common types Neurocognitive disorders:
Prion diseases
-
Prion Diseases:
- Prion diseases are rare neurodegenerativedisorders
caused
by
abnormal
proteins
called
prions
.
Examples includeCreutzfeldt
-Jakob disease
(CJD), whichleads
torapidly progressive dementia.