Neurocognitive Disorders Flashcards

1
Q

Q: How did DSM-5 change the diagnostic criteria related to specific causes of Neurocognitive Disorders?

A

A: DSM-5 includes specific etiological subtypes for Major and Mild Neurocognitive Disorders, such as Alzheimer’s disease, vascular disease, traumatic brain injury, HIV infection, and Parkinson’s disease, providing more detailed criteria for each subtype.

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2
Q

Q: What is a significant terminological change in DSM-5 for Neurocognitive Disorders?

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A: DSM-5 replaced the term “Amnestic Disorder” and Dementia with “Major and Mild Neurocognitive Disorder due to another medical condition” to reflect broader cognitive impairments beyond memory.

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3
Q

Q: What is a new feature of Mild Neurocognitive Disorder in DSM-5 compared to DSM-IV?

A

A: DSM-5 introduced “Mild Neurocognitive Disorder” as a new diagnostic category to identify early stages of cognitive decline that do not yet interfere significantly with daily functioning, which was not recognized in DSM-IV.

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4
Q

Q: How did DSM-5 improve the description of behavioral and psychological symptoms associated with Neurocognitive Disorders?

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A: DSM-5 provides a more comprehensive list of associated features, including mood disturbances, agitation, psychosis, and personality changes, to better capture the full spectrum of symptoms.

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5
Q

Q: What are the main categories included in Neurocognitive Disorders?

A

A: The main categories are delirium, mild neurocognitive disorders, and major neurocognitive disorders.

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6
Q

Q: What are the diagnostic criteria for delirium according to DSM-5?

A

A: The diagnosis of delirium requires (a) a disturbance in attention and awareness developing over a short period (hours to days), representing a change from baseline and fluctuating in severity, and (b) at least one additional cognitive disturbance (e.g., memory or language impairment).

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7
Q

Q: What must be ruled out for a diagnosis of delirium?

A

A: Symptoms must not be better explained by another pre-existing or evolving neurocognitive disorder and must not occur in the context of a severely reduced level of arousal (e.g., coma).

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8
Q

Q: What is required to identify the cause of delirium?

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A: There must be evidence that symptoms are the direct physiological consequence of a medical condition, substance intoxication or withdrawal, and/or exposure to a toxin.

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9
Q

Q: What are common causes of delirium?

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A: Common causes include high fever, nutritional deficiency, electrolyte disturbance, renal or hepatic failure, head injury, and certain drugs and medications (e.g., alcohol, lithium, sedatives, anticholinergic drugs).

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10
Q

Q: In which population is delirium most common?

A

A: Delirium is most common in hospitalized older adults.

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11
Q

Q: What are the primary treatment strategies for delirium?

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A: Treatment involves addressing causal and contributing medical problems, reducing disorientation through environmental manipulation (e.g., providing sufficient lighting, reducing noise), and minimizing the number of visitors.

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12
Q

Q: What medication may be used to treat agitation and psychotic symptoms in delirium?

A

A: Haloperidol or other antipsychotic drugs may help reduce agitation and psychotic symptoms.

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13
Q

Q: What are the core features of Delirium according to DSM-5?

A

A: Disturbance in attention and awareness developing over a short period, fluctuating severity, plus at least one additional cognitive disturbance.

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14
Q

Q: What are common causes of Delirium?

A

A: High fever, nutritional deficiency, electrolyte disturbance, renal or hepatic failure, head injury, certain drugs (e.g., alcohol, sedatives), and medications (e.g., anticholinergics).

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15
Q

Q: How is Delirium treated?

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A: Addressing underlying medical conditions, environmental manipulation (e.g., adequate lighting, reducing noise), and sometimes using antipsychotic medication like haloperidol to manage agitation and psychosis.

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16
Q

Q: What distinguishes Major Neurocognitive Disorder (NCD) from Mild NCD?

A

A: Major NCD involves a significant decline from previous cognitive functioning that interferes with independence, while Mild NCD involves a modest decline that does not interfere significantly with independence.

17
Q

Q: What is a common cause of Major Neurocognitive Disorder?

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A: Neurocognitive Disorder Due to Alzheimer’s Disease, characterized by an insidious onset and gradual progression of cognitive impairment.

18
Q

Q: How is Alzheimer’s Disease definitively diagnosed?

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A: Currently, definitive diagnosis requires a brain biopsy or autopsy, but in vivo diagnosis involves clinical evaluation, imaging, genetic testing, and ruling out other potential causes.

19
Q

Q: What are the hallmark brain abnormalities in Alzheimer’s Disease?

A

A: Amyloid plaques (extracellular) and neurofibrillary tangles (intracellular), primarily affecting medial temporal lobe structures initially and spreading as the disease progresses.

20
Q

Q: What medications are commonly used to treat symptoms of Alzheimer’s Disease?

A

A: Cholinesterase inhibitors (e.g., donepezil, rivastigmine) and memantine, which help manage cognitive symptoms and stabilize memory loss.

21
Q

Q: What are the stages of Alzheimer’s Disease?

A

A: Early stage (2-4 years): Short-term memory loss, personality changes, impaired judgment. Middle stage (2-10 years): Increasing memory loss, mood swings, hallucinations, disrupted sleep, wandering. Late stage (1-3 years): Severe cognitive decline, loss of motor skills, incontinence, infections.

22
Q

Q: What is Mild Neurocognitive Disorder characterized by?

A

A: Modest decline from previous cognitive functioning that may require greater effort or compensatory strategies but does not significantly interfere with independence in daily activities.

23
Q

Q: What are the core features of Neurocognitive Disorder (NCD) with Lewy Bodies according to DSM-5?

A

A: Fluctuating cognition with variations in attention and alertness, recurrent visual hallucinations, symptoms of parkinsonism, symptoms of rapid eye movement sleep behavior disorder, and severe neuroleptic sensitivity.

24
Q

Q: How does Neurocognitive Disorder (NCD) with Lewy Bodies differ from NCD due to Alzheimer’s Disease in terms of early cognitive symptoms?

A

A: NCD with Lewy Bodies presents with deficits in complex attention, visuospatial, and executive functions early on, while NCD due to Alzheimer’s Disease shows early deficits primarily in learning and memory.

25
Q

Q: What distinguishes Neurocognitive Disorder (NCD) with Lewy Bodies from NCD due to Parkinson’s Disease in terms of symptom onset?

A

A: Motor symptoms precede cognitive symptoms in NCD due to Parkinson’s Disease, whereas cognitive symptoms precede or are concurrent with motor symptoms in NCD with Lewy Bodies.

26
Q

Q: What are the core diagnostic criteria for Vascular Neurocognitive Disorder (NCD)?

A

A: Major or minor NCD diagnosis, symptoms suggesting a vascular etiology (e.g., onset related to stroke), and evidence of cerebrovascular disease from history, physical exam, or neuroimaging.

27
Q

Q: What are common risk factors for Vascular Neurocognitive Disorder (NCD)?

A

A: Hypertension, heart disease, diabetes mellitus, obesity, high cholesterol, and heavy cigarette smoking.

28
Q

Q: What are the key symptoms associated with Neurocognitive Disorder (NCD) due to HIV Infection?

A

A: Forgetfulness, impaired attention and concentration, cognitive slowing, psychomotor retardation, clumsiness, tremors, apathy, and social withdrawal.

29
Q

Q: What is a characteristic feature of Neurocognitive Disorder (NCD) due to Prion Disease such as Creutzfeldt-Jakob Disease (CJD)?

A

A: Rapid progression of symptoms, meeting criteria for major NCD within a short timeframe (e.g., six months), and presence of motor symptoms like ataxia, myoclonus, and psychiatric symptoms.

30
Q

Q: What are the different types of Creutzfeldt-Jakob Disease (CJD)?

A

A: Sporadic CJD (unknown etiology), familial CJD (inherited), and acquired CJD (variant CJD from infected meat or iatrogenic CJD from medical procedures).

31
Q

Q: What are the diagnostic criteria for Frontotemporal Neurocognitive Disorder (NCD)?

A

A: Presence of major or mild NCD symptoms, insidious onset and gradual progression, absence of significant impact on learning and memory, and meeting criteria for either behavioral variant (social cognition, executive deficits) or language variant (aphasia).

32
Q
A

Q: What are the main behavioral symptoms of Frontotemporal Neurocognitive Disorder (NCD) in the behavioral variant?

A: Behavioral disinhibition, apathy, loss of empathy, perseverative behaviors, hyperorality, and dietary changes (e.g., overeating).

33
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