NEURO: Vision Flashcards
What side of the retina do the temporal and nasal visual fields focus on?
The temporal visual field focuses on the nasal part of the retina.
The nasal visual field focuses on the temporal part of the retina.
This is because the optics of the eye invert the image.
What gives the eye its shape?
Outer fibrous layer:
- sclera
- cornea
Inner:
- aqueous humour
- vitreous humour
Sclera: eye shape
white non-stretchy layer creating the anchoring point for ocular muscles, keeping the eye rigid
Cornea: eye shape
collagen fibres align in a way to make the outer fibrous layer transparent
Aqueous humour: eye shape
- fluid
- produced by the ciliary body
- flows outwards (front of the eye) and is eventually reabsorbed through the angle of the eye
-the balance between production and reabsorption which generates intraocular pressure keeping the sclera rigid
Vitreous humour: eye shape
jelly-like fluid behind the lens, hydrated by aqueous humour, that maintains shape of eye and keeps it transparent
What gives the eye the ability to focus on an image?
Optics:
- cornea
- lens
- ciliary body
- iris
Cornea: focus
bends light rays to bring them back to a single point (focusing of the image)
Lens: focus
the transparent structure that changes shape to provide the variable fine focus of the eye
*suspended by a ring of suspensory ligaments from the ciliary body
Ciliary Body: Focus
contains a ring of muscle which changes shape of lens by contracting or relaxing:
- contracts to fatten lens for close vision (decreased diameter)
- relaxes to flatten lens for distance vision (increased diameter)
Iris: focus
ring of muscle which creates a coloured part of the eye
controls diameter of the aperture (pupil), controlling how many light eyes the eye via the pupil
-the smaller the aperture, the better the focus
When does the pupil dilate?
dim light to let enough light to give a bright enough image
What structure transmits light information to the brain?
Retina
>Neural retina: contains photoreceptors and afferent retinal ganglion cells which have the axons that run across the surface of the retina and form the optic nerve
> Retinal pigment epithelium: provides a lot of biochemical support for the photoreceptors and also holds the retina in place, preventing it from peeling away
> Optic nerve: central nervous system tract myelinated by oligodendrocytes
How does the eye transmit image/light to the visual cortex?
Primary Visual Pathway:
1) The retinal ganglion cell axons project down the optic nerve to the optic chiasm, and at the optic chiasm, the ones on the nasal half of the retina swap sides. The axons from the temporal half of the retina stay on the same side.
2) They project back to the lateral geniculate nucleus (LGN) in the thalamus.
3) Cells in the lateral geniculate nucleus send their axons through a region of white matter known as the optic radiation back to the occipital cortex, where the primary visual area is located.
What is phototransduction?
The conversion of light into electrical signals in the rods, cones and photosensitive ganglion cells of the retina of the eye
What are photoreceptors?
specialised cells in the retina which respond to light:
Rods- night vision
Cones- day vision
*most of the time the cones are being used
The rods are super-sensitive, so they saturate and become non-functional in high-light levels. They are used mostly in night vision.
The cones are less sensitive but work better in high-light levels. They are used for day vision.
Describe the structure of cone receptors.
> Inner Segment: nucleus and protein-making machinery etc.
> Outer Segment: bag containing tightly packed layers of phospholipid membrane which hold the chromophore (light-sensitive molecule) perpendicular to the light path, ensuring efficient trapping of light rays
> Axon: not really an axon, just a neurite, as it doesn’t fire action potentials, and doesn’t need to because it is a very small cell and can transmit information via electrotonic potentials
> Synaptic Terminal: releases glutamate
What is the resting potential of a cone photoreceptor, and how does it come about?
The resting potential of a cone photoreceptor is -45 mV.
They’re polarised as such because the inner segment has potassium channels that leak K+ out, and the outer segment have sodium channels that are continuously open, so they leak Na+ in.
Electrophysiology of cone photoreceptor at rest
· Photoreceptor nerve cells leak K+ all the time, producing a negative internal potential, resulting in resting membrane potential of -45mV (more depolarised than normal membrane potential -70mV).
· These cells are depolarised even at rest due to Na+ channels in the outer segment being open by default, allowing for the influx of Na+, and there is also glutamate being released from the synaptic terminal
· Glutamate, though usually excitatory, functions here as an inhibitory neurotransmitter
Electrophysiology of cone photoreceptor in response to increased light
· If the light striking the outer segment gets brighter, some of the Na+ channels close, causing the cells to become more negative inside (hyperpolarisation) as there is no more Na+ influx
·This prevents the release of inhibitory glutamate from the synaptic terminals, sending a signal along the visual pathway
Electrophysiology of cone photoreceptor in response to decreased light
· If the region striking the outer segment gets darker, more Na+ channels open, allowing for the influx of Na+ and depolarising the cell
· More glutamate is released from the synaptic terminal
What holds Na+ channels open in photoreceptors?
cGMP