Neuro test 3 drugs

Question 1

Travoprost

Answer 1

Category:
Prostaglandin

MOA
Increase Uveoscleral outflow

Clinical use:
Glaucoma

Question 2

Timolol

Answer 2

Category:
Beta blocker

MOA:
Reduction of aqueous humor production

Use:
Glaucoma

Question 3

Brimonidine

Answer 3

Category:
Alpha agonist

MOA:
Initial reduction of aqueous humor production with subsequent increase in outflow

Use:
Glaucoma

Question 4

Dorzolamide/ Acetazolamide

Answer 4

Category:
Carbonic anhydrase inhibitor

MOA:
reduction of aqueous humor production

Use:
Glaucoma

Question 5

Pilocarpine

Answer 5

Category:
Cholinergic agonist

MOA:
increase aqueous humor outflow

Useu:
Glaucoma

Question 6

Acetazolamide/ Topiramate

Answer 6

Category:
CA inhibitor, decreases CHF production

Use:
IIH

Question 7

Cocaine

Answer 7

MOA:
blocks reuptake of NE

Use:
Horner syndrome
affected eye will not dilate

Question 8

Apraclonidine

Answer 8

MOA:
alpha agonist

Use:
Horner syndrome
Affected eye will constrict

Question 9

Hydroxyamphetamine

Answer 9

MOA:
Release NE

Use:
Horner syndrome
Preganglionic lesions- both will dilate

post- horner will not dilate

Question 10

Dextroamphetamine/amphetamine/ methylphenidate

Answer 10

MOA:
blocks reuptake and increases release of NE and dopamine

Use:
Narcolepsy and CNS hypersomnias

Question 11

Armodafinil

Answer 11

MOA:
dopamine reuptake inhibitor

Use:
Narcolepsy and CNS hypersomnias

Question 12

Venlafaxine

Answer 12

MOA:
SSRI

USE:
narcolepsy with cataplexy

note:
avoid with MOA inhibitors (Serotonin syndrome risk)

Question 13

Sodium Oxybate

Answer 13

MOA:
Decrease presynaptic dopaminergic neuronal firing

Use:
narcolepsy with cataplexy

note:
avoid combo with sedatives and caution with patients with morbid OSA

Question 14

Zolpidem

Answer 14

MOA:
non benzo GABA agonist

Use:
Insomnia

Question 15

Ramelton

Answer 15

MOA:
Melatonin MT1 and MT2 agonist

Use:
insomnia

Question 16

Suvorexant

Answer 16

USE:
orexin receptor antagonist

USe:
insomnia

Question 17

Pramipexole/ Rotlogtine

Answer 17

MOA:
Dopamine agonist

USE:
Restless leg syndrome

Question 18

Gabapentin

Answer 18

MOA:
voltage dependent calcium channel blocker

USE:
Restless leg syndrome

Question 19

Methadone

Answer 19

MOA;
opoid receptor agonist

USE:
restless leg syndrome

Question 20

Flumazenil

Answer 20

MOA:
benzodiazepine antagonist

USE:
BZ overdose

Question 21

Clonazepam

Answer 21

USE:
GABA-benzo agonist

USE:
REM sleep behavior disorder
restless leg syndrome

Question 22

corticosteroids

Answer 22

MOA:
Controls or prevents inflammation

Use:
treat acute relapsing symptoms of MS

Question 23

Avonex/ Betaseron/ Copaxone (glatiramer, acetate)

Answer 23

MOA:
immune modulation

Use:
reduce frequency of relapses and prevention of new MRI MS activity

Question 24

Fingolimod

Answer 24

MOA:
sphingosine-1-phosphate agonist

MOA:
first line option for RRMS (relapsing remitting MS)

Question 25

Teriflunomide

Answer 25

MOA:
pyrimidine synthesis inhibitory

MOA:
first line option for RRMS

Question 26

Dimethyl fumarate

Answer 26

MOA:
unknown, works on Nf2 pathway

MOA:
first line option for RRMS

Question 27

Natalizumab

Answer 27

MOA:
monoclonal antibody against integrin-alpha 4
blocks transmigration of activated immune cell across blood-brain barrier

MOA:
RRMS monotherapy

USE:
consider risk of PML

Question 28

Riluzole

Answer 28

MOA:
inhibits glutamate release
inactivates voltage-gated Na channels

net effect is inhibition of excitatory nt

Use:
ALS

Question 29

Carbidopa/levodopa

Answer 29

MOA:
levodopa –> converted to dopamine

Carbidopa –> blocks peripheral conversion of levodopa to dopamine

Use:
parkinsons

Question 30

Pramipexole/Ropinirole

Answer 30

MOA
Dopamine agonist

USE:
Parkinsons

Question 31

Rasagiline/ Selegiline

Answer 31

MOA:
MAO-B inhibitor

USE:
Parkinsons

Question 32

Enatcapone

Answer 32

MOA:
inhibits COMT enzyme
increases levodopa half-life

USE:
Parkinsons

Question 33

Trihexyphenidyl

Answer 33

MOA:
Anti-cholinergic

USE:
effective for treatment of dystonia and tremors

Question 34

Amantadine

Answer 34

MOA:
blocks NMDA activity and stimulates dopamine release

USE:
mildly effective in reducing dyskinesa from levodopa

Question 35

Propanolol

Answer 35

MOA:
non selective beta blocker

USE:
Essential tremors

Question 36

Primidone

Answer 36

MOA:
metabolized to phenobarbital which increases GABA activity

USE:
Essential tremors

Question 37

Haloperidol/ fluphenazine

Answer 37

MOA:
Dopamine receptor antagonist

USE:
Chorea
psychosis
irritability

Question 38

Clozapine/ Quetiapine

Answer 38

MOA:
D1,2 antagonist, 5HT receptor antagonist, antihistamine

Use:
chorea
psychosis
irritability

Question 39

Tetrabenazine

Answer 39

MOA:
Vesicular monoamine Transporter type 2 blocker (VMAT2)

Use:
Chorea/tics

Question 40

Trihexyphenidyl

Answer 40

MOA:
anticholinergic

Use:
dystonia

Question 41

Baclofen

Answer 41

MOA:
GABA-B receptor agonist

USE:
Dystonia

Question 42

Botulinum toxin

Answer 42

MOA:
temporary destruction of NMJ

Use:
focal dystonia

Question 43

clonidine/ guanfacine

Answer 43

MOA:
alpha-2 adrenergic agnoist

USE:
Tics
ADD/ADHD

Question 44

Clonazepam

Answer 44

MOA:
benzo –> increases GABA activity

USE:
Tics

Question 45

Fluphenazine/ Pimozide

Answer 45

MOA:
Dopamine receptor antagonist

USE:
Tics

Question 46

Zinc

Answer 46

MOA:
Zinc increases clearance of copper from small intestines

USE:
wilson’s disease