Antiparastic

Question 1

Metronidazole

Answer 1

Subclass:
Antiprotozoal

Mech:
Forms intermediates that destroy DNA

Adverse effect:
HA, peripheral neuropathy, alcohol sensitivity

Question 2

Chloroquine

Answer 2

Subclass:
Antiprotozoal

Mech:
Prevents heme polarization to detoxification

Adverse effects:
GI distress/ skin rash/ HA

Question 3

Artemisinins

Answer 3

Mech:
Uncertain…metabolized to free toxic radicals

Adverse effects:
GI distress

Question 4

Quinine

Answer 4

Mech:
uncertain, may act similarly to chloroquine

Adverse effects:
GI distress/ veritgo/ blurred vision

Question 5

Atovaquone

Answer 5

Mech:
Disrupts ETC

Adverse effect:
GI distress

Question 6

Pyrimethamine (proguanil)

Answer 6

Mech:

inhibits protozoal DHFR

Question 7

Albendazole

Answer 7

Mech:
inhibition of microtubule assembly

Adverse effects:
leukopenia with prolonged use

Question 8

Mebendazole

Answer 8

Mech:
inhibition of microtubule assembly

Adverse effects:
GI distress

Question 9

Ivermectin

Answer 9

Mech:
Increases GABA-mediated inhibition and causes immobilization

Adverse effects:
Reactions to dying worms

Question 10

Praziquantel

Answer 10

Mech:

Increases membrane permeability to Ca and causes paralysis