Neuro & Sensory Physiology Flashcards
More numerous Glial of Neurons?
glial
produces CSF
ependymal cells
macrophages of the brain
microglia
regulates ECF ion levels; gives mechanical support forms BBB
astrocytes
creates myelin in the CNS
oligodenrocytes
creates myelin in the PNS
schwann cells
brain tumors from non-mature neurons
neuroblastoma and retinoblastoma
Parts of a neuron: receiving portion of the neuron?
dendrites
Parts of a neuron: where action potential in a neuron actually starts?
axon hillock (initial segment)
Parts of a neuron: function of myelin sheath?
insulator
Parts of a neuron: unmyelinated portion of the axon?
nodes of ranvier
Parts of a neuron: branches of the axons?
neural fibril
Parts of a neuron: terminal portion of a neural fibril that contains NT-containing vesicles?
axon terminal/ boutons/end feet
Parts of a neuron: space between two neurons
synapse
opening of Na-activation gates (Na influx)
depolarization
closure of Na-inactivation gates + opening of K channels (K efflux)
repolarization
membrane potential where AP is inevitable
threshold
portion of AP where MP is positive
overshoot
portion of AP where MO is <RMP
undershoot
no AP cab be elicited despite increase stimulus
ARP
more inward current needed to generate AP
RRP
other names: Na activation gates
M gate
other names: Na inactivation gates
H gate
other names: potassium gates
N gate
give two sodium channel blockers of neurons?
tetradotoxin (TTX- puffer fish) and Saxitoxin (dinoflagellates)
give an example of K channel blockers of neurons
tetraethylammonium
causes activation of synaptic vesicles
Ca+2 voltage gated channels
death of axon distal to site of injury?
anterograde degeneration (aka valerian degeneration?)
changes to SOma after axon is transected?
axonal reaction/ chromatolysis
give examples of disease utilizing retrograde axonal transport?
tetanus; butolism
axonal regeneration occurs better in which of the ff: CNS or PNS?
PNS
what is the principle that in the spinal cord the dorsal roots are sensory and the ventral roots are motor?
Bell-Magendie Law
Neurotransmitters: found in the NMJ sympa and Para preganglionic neurons, para and some sympa post-gaglionic neurons?
ACh
found in the basal ganglia, large pyramidal cells of the motor cortex, gigantocellular neurons of the REA maybe excitatory or inhibitory?
ACh
triggers REM sleep
ACh
decreased levels in Huntingtons dementia and alzheimers dementia
ACh
found in the lucus ceruleus of pons, post-ganglionic sympa, for arousal/ wakefulness
norEpi
secreted mainly by the adrenal medulla
Epiniphrine (80%) while norepi is 20%
found in the median raphe of the brain stem, from tryptophan converted to melatonin involved in mood and sleep
serotonin
from arginine, not pre-formed (synthesize as needed) permeant gas
Nitric oxide
Mnemonic “ ILOCUS NORte”
LOCUS ceruleus = NORepinephrine
Mnemonic “ phenylalanine derivatives”
Pare true love does not exist to me
“Phenylalanine, tyrosine, L-dopa, dopamine, NE, epiniphrine, thyroxine, melanin”
Mnemonic Tryptophan derivatives
“trip mo sya noh?”
tryptophan, Melatonin, serotonin, Niacin
Neurotransmitters: found in the spinal interneurons main inhibitory NT; increases chloride influx?
glycine
Neurotransmitters: found in the brain, mainly inhibitory NT, from glutamate, increase chloride influx or potassium efflux
(GABA-a) (GABA-B)
Neurotransmitters: excitatory NT in the CNS activate NMDA receptors
glutamate
Neurotransmitters: inhibits neurons in the brain involved in pain perception
opiod peptides
Neurotransmitters: involved in Fast pain
and Slow pain
glutamate
substance P
the brain, lobe: hearing and balance
temporal lobe
the brain, lobe: vision
occipital lobe
the brain: lobe motor
frontal lobe
the brain: lobe somato sensory
parietal lobe
the brain: sex, thirst, appetite, body clock, temp
hypothalamus
the brain: coughing, vomiting, swallowing, resp, and vasomotor center
medulla
the brain: apneustic, pneumotaxic center
pons
the brain: micturaion center
pons
the brain: behaviour emotions motivation
limbic system
location: broca’s area
opercular/triangular part of the Inferior frontal lobe BA 45