Neuro-pharmacology - basics

Question 1

what are the four fundamentals of pharmacokinetics

Answer 1

absorption, distribution metabolism and excretion

Question 2

what GI issue can lead to sub-therapeutic phenytoin levels ?

Answer 2

antacids/low pH in the stomach

Question 3

Three things that effect volume of distribution

Answer 3

lipid solubility
total body mass
percentage of body fat

Question 4

what type of molecules easily cross the BBB ?

Answer 4

lipid soluble (hydrophilic have difficulty)

Question 5

how does drug inactivation occur ?

Answer 5

cytochrome p450 enzyme pathways and conjugation

Question 6

Name 5 commonly prescribed p450 INHIBITORS

Answer 6

Diltiazem, Amiodarone, Metronidazole, FLUoxetine, verapamil

Question 7

PHT, PHb, TPM and CBZ are all P450 ____rs.

Answer 7

inducers (TPM >200mg/d)

Question 8

p450 enzyme that effects response to clopidogrel

Answer 8

CYP2C19

Question 9

Pts of asian descent starting on CBZ should be screened for this HLA allele.

Answer 9

HLA-B*1502