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CU Child Neuro Epilepsy > Neuro-Pharmacology - AEDs > Flashcards

Neuro-Pharmacology - AEDs Flashcards

1
Q

MOA: Phenobarbital (PHb)

A

prolongs opening of Cholride channels via GABA binding

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2
Q

MOA: Phenytoin (PHT)

A

sodium channel blocker

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3
Q

MOA: carbamazepine

A

sodium channel blocker

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4
Q

MOA: Oxcarbazepine (OXC)

A

sodium channel blocker

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5
Q

MOA: Eslicarbazepine

A

sodium channel blocker

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6
Q

MOA: Valproate (VPA)

A

GABA potentiation, T-type Ca channel blocker, sodium channel blocker

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7
Q

MOA: Ethosuximide

A

t-type calcium channel blocker

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8
Q

MOA: Clobazam (CBZ)

A

Increases FREQUENCY of GABA-mediated Chloride channel opening

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9
Q

MOA: Felbamate (cenobamate is the new FDA approved one)

A

sodium channel blocker, NMDA antagonist, gabaergic

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10
Q

MOA: Gabapentin

A

voltage gated calcium channel blocker

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11
Q

MOA: Pregabalin

A

voltage gated calcium channel blocker

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12
Q

MOA: Lamotrigine (LTG)

A

sodium channel blocker, inhibits glutamine release

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13
Q

MOA: Topiramate (TPX)

A

AMPA antagonist, GABA augmentation, sodium channel blocker

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14
Q

MOA: Tiagabine

A

GABA reuptake inhibitor

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15
Q

MOA: Levetiracetam (keppra)

A

SV2A vesicle protein binder

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16
Q

MOA: Brivaracetam (briviact)

A

SV2A vesicle protein binder

17
Q

MOA: Zonisamde

A

t-type calcium channel blockers, sodium channel blockade, carbonic anhydrase inhibitor

18
Q

MOA: Lacosamide (Vimpat)

A

sodium channel blocker

19
Q

MOA: Rufinamide

A

sodium channel blocker

20
Q

MOA: Ezogabine

A

potassium channel blocker (taken off market)

21
Q

MOA: Perampanel

A

AMPA receptor antagonist

22
Q

MOA: Vigabatrin

A

IRREVERSIBLE inhibitor of gaba transaminase

23
Q

MOA: Primidone

A

prlonges opening of chloride channels via gaba binding

24
Q

Name two AMPA antagonsits

A

TPX and Perampanel

25
Q

Is primidone an inducer or inhibitor of cyp ?

A

inducer

26
Q

3 of the worse drugs for major congenital malformations

A

VPA, PHb, TPX

27
Q

2 of the safest drugs during pregnancy

A

LTG and LEV

28
Q

AEDS that work for Bipolar as well

A

LTG, VPA

CU Child Neuro Epilepsy (19 decks)

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