AED half lives Flashcards

1
Q

Acetazolamide

A

12-14 hours

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2
Q

Carbamazepine

A

10-20 hrs (after autoinduction); 24-60hrs (initial)

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3
Q

Clobazam

A

24-48 hours (N-desmethylclobazam - 3-4 days)

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4
Q

Clonazepam

A

20 hours (children); 20-60 hrs (adults)


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5
Q

Eslicarbazepine

A

12-20 hours


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6
Q

Ethosuximide

A

30-40 hours


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7
Q

Ezogabine

A

8 hours

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8
Q

Felbamate

A

20 hours


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9
Q

Gabapentin

A

5-8 hours

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10
Q

Lacosamide

A

13 hours

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11
Q

Lamotrigine

A

25 hours

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12
Q

Levetiracetam

A

6-8 hours


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13
Q

Oxcarbazepine

A

8-12 hours (including derivative; parent drug = 2hrs)

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14
Q

Perampanel

A

100 hours (4 days)

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15
Q

Phenobarbital

A

2-7 days

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16
Q

Phenytoin

A

10-30 hours

17
Q

Pregabalin

A

6-10 hours

18
Q

Tiagabine

A

7-9 hours

19
Q

Topiramate

A

20 -24 hours

20
Q

Valproate

A

6-12 hours

21
Q

Vigabatrin

A

5-8 hours (increases with age of pt)

22
Q

Zonisimide

A

60 hours

23
Q

Stiripentol

A

8hrs (children); 24hrs (adult)

24
Q

Cannabidiol

A

50-60hrs