Neuro- Path Flashcards

1
Q

When does myelination occur in the development of the CNS

A

late in embryonic development

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2
Q

Spina bifida is a failure of…

A

…closure of the neural tube

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3
Q

What is spina bifida Rachischisis?

A

extreme defect with the spinal column converted into gaping canal

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4
Q
A

Rachischisis

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5
Q

Neural tube nefects are complicated by what deficient vitamin deficiency?

A

Folate Vitamin B9

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6
Q

Differentiate Dimyelia and Diastematamyelia

A

Complete duplication is dimyelia and partial duplication is diastematamyelia

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7
Q

What is the difference between a hydromyelia and a syringomyelia

A

Hydropmyelia is a abnormal dilation of the central canal lined by ephendyma cells. These are expansion of the central canal

Syringomyelia is a tubular cavitation which extends for variable distances that may or not communicate with the central canal. They have no lining

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8
Q

What is a syringobulbia?

A

a Synringomyelia of the medulla

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9
Q

Non-progressive damage to the brain. Movement disorder and impaired muscle movement. Occurs before, during or shortly after birth

A

Cerebral palsy

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10
Q

Premature births are associated with what risk?

A

Intraparenchymal hemorrhage (hemorrhage near thalamus and caudate nucleus that may cause hydrocephalus)

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11
Q

Periventricular leukomalacia?

A

An Intraparenchymal hemorrhage develops into an infarct. The white matter becomes necrotic and calcifies.

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12
Q

Multicystic encephalopathy

A

a intraparenchumal hemorrhage that involves both the white and grey matter cause destructive cystic lesions

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13
Q

Differentiate spastic, athetoid, ataxic, and mixed cerebral palsies

A

Spastic = tense, contracted muscles

Athetoid = uncontrolled motions

Ataxic = poor sense of balance, falling

Mixed = combination thereof

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14
Q

What type of hydropcephalus is Chiari malformation?

A

Communication because all the ventricles are distended

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15
Q

Type I versus a Type II Chiari Malformation?

A

Type I will not include a meningomyelocele

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16
Q

What is a key feature of a non-communicating hydrocephalus from a blockage of the foramen of monroe?

A

Position headaches

17
Q
A

Pachygyria

18
Q

lissencephaly

A

cortical surfaces are smooth or imperfectly formed gyri

19
Q

heterotopias

A

focal defects that lead to modules of ectopic neuronsmay be caused by maternal alcoholism

20
Q

Arrhinencephaly

A

absence of olfactory tracts and bulbs (rhinencephalon) associated with holoproericephaly or as solitary lesion

21
Q

Associated with Trisomy 13 -15

A

Holoprosencephaly and Arrhinencephaly