Neuro-oncology Flashcards

1
Q

Opsoclonus myoclonus syndrome is associated with what tumor in children?

A

neuroblastoma

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2
Q

How do you typically treat meningeal carcinomatosis?

A

whole brain radiation + intraventricular methotrexate

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3
Q

Gamma knife is usually used to threat what?

A

focal lesions

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4
Q

What do you see on pathology in GBM?

A

perinecrotic pseudopalisading

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5
Q

What tumor has a “friend egg” appereance?

A

oligodendroglioma

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6
Q

What tumor has perivascular pseudorosettes?

A

ependymomas

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7
Q

What tumor has homer wright rosettes?

A

medulloblastoma

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8
Q

What is the predominant antibody in paraneoplastic optic neuropathy?

A

anti-CRMP-5
*associated with lung cancer

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9
Q

What is the predominant antibody in paraneoplastic retinal degeneration?

A

anti-recoverin or anti-CAR
*small cell lung cancer, thymoma, renal cell carcinoma, melanoma

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10
Q

What is the predominant antibody in paraneoplastic subacute sensory neuropathy and neuronopathy?

A

anti-Hu
*small cell lung cancer

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11
Q

What is the predominant antibody in paraneoplastic cerebellar degeneration?

A

Anti-Yo
*ovarian, GYN cancers as well as breast cancer

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12
Q

What mutation is associated with nearly half of anaplastic astrocytomas?

A

p53

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13
Q

“Cancle gutterings” can be seen in what tumor?

A

subependymal giant cell astrocytoma

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14
Q

is SEGA benign or malignant?

A

benign, WHO grade 1

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15
Q

In terms of oligiodendrogliomas, is a 1p19q deletion better or worse in terms of survival?

A

better

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16
Q

Myxopapillary ependymoma almost exclusively where?

A

filum terminale

17
Q

Neurocytoma is positive for what marker?

A

synaptophysin
*negative for GFAP (unlikely oligodendroglioma)

18
Q

Psammoma bodies are seen in what brain tumor?

A

meningiomas

19
Q

Which tumor causes temporal lobe seizures?

A

DNET

20
Q

Which tumor is filled with “machine oil like fluid” and if spilled can cause xanthogranulomatous inflammation?

A

craniopharyngioma

21
Q

Where are chordomas usually found?

A

clivus and sacrococcygeal region

22
Q

Which tumor is an invasive osseodestructive tumor?

A

chordomas
*made of physaliphorous cells

23
Q

Which tumor has a biphasic pattern with a more compact phase (antoni A) and a looser pattern (antoni B) ?

A

vestibular schwannoma
*have verocay body

24
Q

What is the size difference between pituitary microadenoma vs macroadenoma?

A

If it is >1 cm it is a macroadenoma

25
Q

What tumor is positive GRAP and Ki-67

A

astrocytoma

26
Q

Polymyositis is associated with what malignancies?

A

non hodgkins lymphoma, lung and bladder cancer

27
Q

dermatomyositis is associated with what cancers?

A

ovarian, lung, gastric, colorectal, pancreatic and non hodgkins lymphoma

28
Q

What antibody is most commonly detected in paraneoplastic limbic encephalitis?

A

anti-Hu
strongly associated with small cell lung cancer

29
Q

opsoclonus myoclonus syndrome is most commonly associated with what anitbody especially in the setting of breast cancer?

A

anti-Ri (ANNA 2)