Neuro-oncology Flashcards
Opsoclonus myoclonus syndrome is associated with what tumor in children?
neuroblastoma
How do you typically treat meningeal carcinomatosis?
whole brain radiation + intraventricular methotrexate
Gamma knife is usually used to threat what?
focal lesions
What do you see on pathology in GBM?
perinecrotic pseudopalisading
What tumor has a “friend egg” appereance?
oligodendroglioma
What tumor has perivascular pseudorosettes?
ependymomas
What tumor has homer wright rosettes?
medulloblastoma
What is the predominant antibody in paraneoplastic optic neuropathy?
anti-CRMP-5
*associated with lung cancer
What is the predominant antibody in paraneoplastic retinal degeneration?
anti-recoverin or anti-CAR
*small cell lung cancer, thymoma, renal cell carcinoma, melanoma
What is the predominant antibody in paraneoplastic subacute sensory neuropathy and neuronopathy?
anti-Hu
*small cell lung cancer
What is the predominant antibody in paraneoplastic cerebellar degeneration?
Anti-Yo
*ovarian, GYN cancers as well as breast cancer
What mutation is associated with nearly half of anaplastic astrocytomas?
p53
“Cancle gutterings” can be seen in what tumor?
subependymal giant cell astrocytoma
is SEGA benign or malignant?
benign, WHO grade 1
In terms of oligiodendrogliomas, is a 1p19q deletion better or worse in terms of survival?
better
Myxopapillary ependymoma almost exclusively where?
filum terminale
Neurocytoma is positive for what marker?
synaptophysin
*negative for GFAP (unlikely oligodendroglioma)
Psammoma bodies are seen in what brain tumor?
meningiomas
Which tumor causes temporal lobe seizures?
DNET
Which tumor is filled with “machine oil like fluid” and if spilled can cause xanthogranulomatous inflammation?
craniopharyngioma
Where are chordomas usually found?
clivus and sacrococcygeal region
Which tumor is an invasive osseodestructive tumor?
chordomas
*made of physaliphorous cells
Which tumor has a biphasic pattern with a more compact phase (antoni A) and a looser pattern (antoni B) ?
vestibular schwannoma
*have verocay body
What is the size difference between pituitary microadenoma vs macroadenoma?
If it is >1 cm it is a macroadenoma
What tumor is positive GRAP and Ki-67
astrocytoma
Polymyositis is associated with what malignancies?
non hodgkins lymphoma, lung and bladder cancer
dermatomyositis is associated with what cancers?
ovarian, lung, gastric, colorectal, pancreatic and non hodgkins lymphoma
What antibody is most commonly detected in paraneoplastic limbic encephalitis?
anti-Hu
strongly associated with small cell lung cancer
opsoclonus myoclonus syndrome is most commonly associated with what anitbody especially in the setting of breast cancer?
anti-Ri (ANNA 2)
