neuro/ endo/ musculoskeletal/ mental health Flashcards
- Bipolar first-line treatment, what are the risks and how often check labs?
Lithium is the GOLD standard
*Risk of neurotoxicity (alters the normal activity of the nervous system) with serum levels > 2.0
* Draw levels 2 x week until levels are stable, then every 1-3 months
* adversely affects kidneys in 20 % of patients
- Suicide risk factors
o Ages 15-24 and > 60 y/o
o Older people who have recently lost a spouse (death or divorce)
o Plan involving a gun or other lethal weapon/firearms in the house
o Hx of attempted suicide and/or family hx of suicide
o Mental illnesses (depression or bipolar)
o Hx of sexual, emotional and/or physical abuse
o Terminal illness, chronic illness/chronic pain
o Alcohol/substance abuse
o Stressful life issues (financial or relationship problems)
o Medical professionals/public service
o American Indian and Alaskan native youth/middle age have the highest risk
o Blacks have the lowest risk
- Brain tumor symptoms
*New onset HA (mild-severe), throbbing, progressively worse,
*unexplained n/v,
*blurred/double vision,
*gradual loss of sensation of movement in extremities, off-balance,
*slurred speech
Brain tumor Differential dx:
o CVA, MS, SAH, meningitis, optic neuritis, AVF, brain abscess, neurosyphilis
Brain tumor Treatment:
surgery, radiation, chemo, meds/steroids
Seizure disorder cause
Caused by a sudden burst of electrical activity from a collection of cerebral cortex neurons which affect motor, sensory, and cognition
Generalized seizures verses partial seizures
Generalized seizures are associated with a complete loss of consciousness, whereas partial seizures preserve wakefulness; involuntary twitching or stiffness in the body
What are the 2 types of focal seizures and what are focal seizures?
Focal (affecting just one part of the brain):
- Complex partial- impairs LOC
- Simple partial- LOC not impaired (motor-sensory is affected)
What are generalized seizures and what are the 5 kinds?
(affecting the entire brain)
1. tonic-clonic/”grand mal”-sudden stiffening of muscles/contractions
2. absence sz-“blank stare” or brief interruption in activity
3. myoclonic-sudden, brief, shock-like contractions, usually during sleep
4. tonic-sudden muscle stiffening, sudden without warning and can lead to injury
5. atonic-sudden loss of muscle control , sudden without warning and can lead to injury
Treatment of seizures:
Do you treat seizures first time?
How do you choose a medication?
What is preferred in treatment?
First-line focal seizure treatment?
*No medication recommended for 1st time seizure
*Choice of med depends on type of sz, comorbities, etc
*Monotherapy is preferred (achieve best control of sz with least meds possible)
Focal Seizures
* 1st line: Carbamazepine (Tegretol) or lamotrigine (Lamictal)
- Parkinson’s s/sx
Who gets it?
TRIAD (rest tremors, muscular rigidity, bradykinesia)
> 50 y/o
more common in men
What is Parkinson’s 1st line Treatment?
What is the treatment for essential tremors?
Treatment
*1st line: Sinemet TID 25/100mg PO TID with meal or snack to avoid nausea
* Start low and titrate slowly
*For essential tremors: propranolol 60-320mg daily or long-acting (Inderal LA)
Parkinson’s tests
There are no specific tests
*Get a good H&P
*look for s/s and red flags
Multiple sclerosis Symptoms
*Fatigue (95% of patients)
* visual loss, diplopia, nystagmus and optic neuritis
* Vertigo
* Walking/balance problems/Ataxic gait
* Weakness of the legs/Foot drop
* Paresthesias of extremities
* Bowel or urinary dysfunction
* Electric shock like sensation runs down the back when bending neck forward
*Muscle spasms, stiffness/weakness
Multiple sclerosis tests
How can a diagnosis be made?
What criteria is used?
What two other tests can be orderd?
*The key is to get a good H&P.
For the dx to be made, 2 or more areas of the CNS must be involved at 2 different periods of time (Vision, speech, strength, coordination, balance, position)
* MRI of brain, spine may show lesions
* LP-eval for lymphocytes and IgG bands)
* McDonald criteria (H&P, lesions or lab tests, MRI)
Multiple sclerosis Treatment:
What are the goals?
What treats acute exacerbations (mainstay of treatment)?
What else can you use?
Should you refer?
3 major goals:
1. delay progression
2. manage symptoms
3. treat acute flares
*Glucocorticoids are the mainstay of treatment for acute exacerbations
*Can also use IV Depomedrol and/or oral prednisone
*Refer to neurology
*Disease-modifying therapies (B-Interferon which are substances which help immune system fight disease)
What is Myasthenia gravis?
Autoimmune dx caused by an error in the transmission of nerve impulses to muscles
Myasthenia gravis s/sx
*muscle fatigue,
* weakness with use,
*eye movements and speech are affected
*weakness of the eye muscles, drooping of the eyelid, blurred vision, changes in facial expressions, dysphagia, dyspnea, dysarthria
s/s are usually worse later in the day, may subside with rest
Myasthenia gravis Test?
What is a positive test?
What else could they do?
*Tensilon test: Tensilon drug is injected into the muscles which prevents the breakdown of Ach (neurotransmitter that nerve cells release to stimulate your muscles)
* A positive test for MG if their muscles get stronger after the injection
*EMG (electrymyography)-electrodes used to assess the health of muscles and nerve cells)
*Serum antibodies (IgG) as a rescue med but not long term while you’re waiting for meds to take effect
Myasthenia gravis Treatment
Drug of choice?
Other drugs?
Other treatment?
What should patients be screened for?
*Symptomatic and supportive treatment
-Meds
* Mestinon/pyridostigmine is the drug of choice
* Steroids
* Immunosuppressants
* IVIG
* Plasmapheresis
All pts should be screened for thymoma; thymectomy can be curative
Carpel tunnel :
What else is it called?
What causes it?
What are the s/sx?
Hallmark symptom?
“wake and shake syndrome”
*Caused by entrapment neuropathy of the median nerve at the wrist
s/s: gradual onset (wks to months); paresthesia on the thumb, index finger, and middle finger areas; weak grip; hx occupation/hobby with repetitive hand movements
*aching sensation that radiates into the thenar area (base of the thumb)
Hallmark symptom-nighttime awakening with pain and numbness
Carpel tunnel tests
tests:
Most useful dx test is a median nerve conduction velocity study ($$$)
Tinel’s sign: tapping the anterior wrist briskly causes pins and needles sensation along the median nerve
Phalen’s sign: flex both hands against each other for 1 min; positive if tingling down median nerve
Carpel tunnel treatment
Treatment
*NSAIDs or steroid injections
*Splints
*Avoid aggravating factors
*Ortho referral
*Surgery for decompression of the carpal tunnel with release
- Rheumatoid arthritis
- Rheumatoid arthritis tests
What is the preferred test?
What are other tests?
Tests:
RA classification criteria Scale
Preferred test: Rheumatoid factor (RF)-an IgM autoantibody
* positive in 70-80% of patients (20% may be negative despite other RA s/s)
*Serology/antibodies: ANTI-CCP (anti-cyclic citrullinated peptide protein) only for people with RA
*Sed rate, CRP, (both show infllmation in the blood) and PLTS may be elevated in acute phases
*ANA may be helpful; usually negative, but can be positive in 20-30% of patients
*Radiographs: bony erosions, joint space narrowing, subluxations or dislocations
- Rheumatoid arthritis s/sx
*Key physical finding: symmetric polyarthritis and morning stiffness > 1 hr
Symptoms are usually present for 9 months prior to diagnosiss/s can be acute over 24 hours or gradual over months
*middle-aged adult (women>men)
*s/s: weakness, daily fatigue; depression low-grade fever; weight loss/decreased appetite; body aches/joint pains-bilateral; myalgias; lymphadenopathy; joint pains start on the fingers/hands; early morning stiffness; pain, warm, tender, and swollen fingers (“sausage joints”) PIP/MCP; eventually involve the majority of joints bilaterally
- What is the recommended screening age for DEXA scan?
Women: >= 65 y/o or younger If high risk for fractures
o Men: >70= y/o or at high risk for thinning bones
A1C, how often tested if it’s not normal? Normal A1C? prediabetic? diabetic?
Test every 3 months, until BG is controlled (or if changing therapy), then 2x year
What is a normal a1c? < 5.7%
What is an abnormal a1c? 5.7-6.4% = prediabetic
What does the a1c have to be to be considered diabetic? > =6.5 %
- What is considered prediabetes?
Impaired Fasting glucose 100-125 OR
OGTT 140-199 OR
A1C: 5.7-6.4
Normal fasting glucose for non-diabetic:
- <100 (ADA)
What is considered diabetes?
Diagnosis requires 2 abnormal test results
Fasting plasma glucose > =126
A1C > =6.5
Non-fasting glucose > =200
When and why should diabetic screening begin?
o Type 1:
For children at age 10 or onset of puberty, if overweight (>85 percentile) with 1 or more risk factors
* Maternal hx of DM or GDM
* Family hx of T2DM in 1st or 2nd degree relative
* Insulin resistance (obesity, acanthosis nigricans, etc)
* If they display s/s (weight loss, excessive hunger, fruity breath, ketones in urine, viral-like illnesses)
Goal for A1C
* < 7.5 for children/teens
* <7.0 for aduts