Neuro: embryo, A&P random memorization Flashcards
What day are the neural crest cells formed?
Day 21
What’s the embryologic origin of Schwann cells?
NCCs
What’s the embryologic origin of oligodendrocytes?
Neuroectoderm
You’ve already found increased AFP. Increased levels of what other enzyme in amniotic fluid help confirm a neural tube defect?
Fetal AChE
What’s it called when meninges and spinal cord both herniate through a spinal canal defect?
Meningomyelocele
What maternal auto-immune condition is associated with anencephaly?
DM 1
Mutations in what signaling pathway are thought to be related to holoprosencephaly?
Sonic hedgehog
What structure transmits input to the cerebellum from the contralateral cortex?
Middle cerebellar peduncles
Which structure transmits ipsilateral proprioceptive info from the spinal cord to the cerebellum?
Inferior cerebellar peduncles
What are the output nerves of the cerebellum?
Purkinje cells
Cerebellar purkinje cells signal the deep cerebellar nuclei, which then transmit info to the contralat cortex via what structures?
Superior cerebellar peduncles
Lateral cerebellar lesion: do you fall toward or away from the injured side?
Toward
Anterior limb of internal capsule: what 2 nuclei does it run btwn?
Caudate and lentiform
What’s the blood supply to the anterior limb of the internal capsule?
ACA: medial striate branches
MCA: lateral striate branches
The genu of the internal capsule contains what fibers?
Corticonucleate
What’s the blood supply to the genu of the internal capsule?
ICA: direct branches
Anterior choroidal a: pallidal brnaches
What 2 structures does the posterior limb of the internal capsule run btwn?
Thalamus and lentiform nucleus
What’s the blood supply of the posterior limb of the internal capsule?
Anterior choroidal a
MCA: lateral striate branches
In PD, what are Lewy bodies made of?
Alpha-synuclein
Exposure to what drug has been linked to Parkinson’s dz (albeit a rare link)?
MTMP
An intention tremor can signal dysfunction of what part of the brain?
Cerebellum
What is a blepharospasm?
Sustained eyelid twitch (a type of dystonia)
Kluver-Bucy syndrome has been linked to what type of viral encephalitis?
HSV-1
A lesion of what general area can cause spatial neglect syndrome?
Right parietal-temporal cortex
Someone has agraphia, acalculia, finger agnosia, and L-R disorientation. What’s the name for this syndrome?
Gerstmann syndrome
Gerstmann syndrome is seen with lesions in what general area of the brain?
Left parietal-temporal cortex
Lesion of what area causes hemiballismus? Is it ipsilat or contralat?
Subthalamic nucleus; contralateral
What is it called when you can’t make new memories?
Anterograde amnesia
PPRF lesion: do eyes look toward side of lesion or away?
Away from side of lesion
Frontal eye fields lesion: do eyes look toward side of lesion or away?
Toward side of lesion
Which hypothalamic nucleus drives sleep?
SCN
SCN releases a neurotransmitter that stimulates the pineal gland to release melanin. What is this neurotransmitter?
NE
How does duration of REM change throughout the night?
Increases
DOC for bedwetting?
DDAVP
How do you treat night terrors and sleepwalking?
Don’t sleep. Sleep is for bitches and PT students. JK… BNZs
EtOH, BNZs, and barbiturates decrease what two types of sleep?
Delta wave and RREM
Which EEG wave has the highest freq and lowest amplitude? What two (physiologic) times is it seen?
Beta waves; REM sleep and when you’re awake with your eyes open
When do you see alpha waves on EEG?
Awake with eyes closed
What’s the shortest stage of sleep?
N1
WTF is bruxism and what sleep stage does it occur during?
Teeth grinding; N2
When do you see sleep spindles and K complexes
Stage N2
What stage do sleepwalking, night terrors, and bedwetting occur?
Stage N3
What waveforms are on the EEG in stage N3 sleep?
Delta
What’s the most important neurotransmitter in REM sleep induction?
ACh
What does the OVLT sense?
Changes in osmolarity
How can infarction or neoplasm lead to cerebral vasogenic edema?
They destroy BBB endothelial cell tight junctions
Which part of a nerve invests single nerve fiber layers?
Endoneurium
Which part of a nerve surrounds a fascicle of nerve fibers?
Perineurium
What’s the name of the dense CT surrounding an entire nerve (including fascicles + blood vessels)?
Epineurium
What 2 muscles elevate the tongue?
Styloglossus
Palatoglossus
What level do the vertebral AAs enter the spinal column, and through what foramina do they travel upward?
C6; transverse foramina
What is a classic way that the vertebral arteries can be compressed in OA?
Osteophyes–>external compression as they travel through the transverse foramina
What’s a potentially lethal complication of rapid correction of hyponatremia?
Central pontine myelinolysis
What’s a potentially lethal complication of rapid correction of hypernatremia?
Cerebral edema +/- herniation
How low does PO2 have to be before hypoxemia increases cerebral perfusion P?
<50 mmHg
At what level of PCO2 does cerebral perfusion P stop being directly proportional to PCO2?
> 90 mmHg
What cells make the CSF?
Ependymal cells of the choroid plexus
Hydrocephalus ex vacuo: what causes the apparent increase in CSF?
Decreased neural tissue
What kind of shunting should you use in treatment of normal P hydrocephalus?
Ventriculoperitoneal shunting
Vertebral disc herniation: what structure actually herniates through the annulus fibrosis?
Nucleus pulposus
In adults, how far down does the spinal cord extend?
L1-L2 vertebrae
In adults, how far down does the subarachnoid space extend?
Lower border of S2 vertebra
25 y/o woman with scanning speech, intention tremor, and nystagmus. Dx?
MS
What mutation is seen in some familial cases of ALS?
SOD-1 mutation
At what vertebral level does the artery of Adamkiewicz start supplying ASA territory?
Below T8
What 2 sites does poliovirus replicate in before it spreads to blood?
Oropharynx and small intestine
What inheritance pattern does Werdnig-Hoffman dz have?
AR
What gene is disabled in Friedrich ataxia?
Frataxin
What is the normal fxn of frataxin? What happens when it’s impaired in FA?
It’s essential for mitochondrial Fe regulation. Impairment–>Fe buildup–> FR damage
Ant 2/3 of the tongue is formed by which pharyngeal arches?
1st and 2nd
Post 1/3 of the tongue is formed by which pharyngeal arches?
3rd and 4th
What are the tongue muscles derived from?
Occipital myotomes
What structure separates the ant 2/3 from post 1/3 of the tongue?
Terminal sulcus
*foramen cecum also would have been an acceptable answer as it lies at the midline in the terminal sulcus
Ant 2/3 of tongue: taste and sensation from?
Taste: 7
Sensation: V3
Post 1/3 of tongue: taste and sensation from?
CN 9
Extreme posterior tongue: sensation from?
CN X