Neuro-Degenerative Disorders Flashcards
1
Q
Treatment of Dementia
A
Ach Esterases inhibitor
Donepezil, Galantamine, Rivastigmine
Used in mild to moderate dementia
NMDA glutamate receptor antagonist
Memantine
Used in moderate to severe dementia
2
Q
Causes of Neurodegeneration
A
Toxins
Protein Handling disorders (e.g Hyperphosphorylated tau/intracellular tangles; Amyloid beta aggregrates/extracellular plaques in Alzeheimers; alpha synuclein in Parkinsons) Lack of GF Oxidative stress from free radicals Excitotoxicity - too much glutamate Ionic Dysequalibrium Mitochondria dysfunction Activation of cell death pathways Autoimmune attacks
