Neuro Flashcards
Basal Ganglia: Description
The basal ganglia is a group of nuclei located in the deep white matter of the brain. That is interconnected with the cerebral cortex, thalami and brain stem.
Function: Memory formation and regulation of motor control
Basal Ganglia: Gross Anatomy
- Gross anatomy:
- It contains 3 paired nuclei that together comprise the corpus striatum:
- Caudate nucleus
- Putamen
- Globus pallidus
Caudate Nucleus
- Located lateral to the lateral ventricle
- Head indents the anterior horn
- Curves along the lateral ventricle
- Tail extends into the temporal lobe
- Bounded laterally by the internal capsule
- The head of the caudate is supplied by the recurrent artery of Heubner, the rest is supplied by the lenticulostriate arteries
Putamen
- Paired rounded, most lateral structure of the basal ganglia
- Medial to the external capsule
- Connected to the substantia nigra and subthalamic nuclei to control movement
- Supplied by the lenticulostriate arteries
Globus Palladus
- Paired, medial to the putamen, lateral to the thalamus
- Subdivided into internal and exernal parts separated by the internal medullary lamina.
- Supplied by the lenticulostriatal arteries
Subthalamic Nuclei
- Small, located inferior to the thalamus
- Medial to internal capsule
Substantia Nigra
- Anterior midbrain, transition point of the tegmentum and cerebral peduncles
- Produces dopamine
Cerebellum: Description
There cerebellum is brain structure located in the posterior fossa below the tentorium and behind the brain stem
Function: Integration and mediation of proprioceptor and movement data
Cerebellum: Gross Anatomy
- Globular structure located in the posterior aspect of the posterior fossa
- Three surfaces: anterior, superior and inferior
- Three fissures: Primary, horizontal and sub-occipital
- Two hemispheres: right and left
- Single median vermis
Cerebellar divisions
- Vermis: Divided into nine lobules
- Cerebellar hemispheres:
- Onion configuration of folia
- 18 lobules associated bilaterally associated with the vermis lobules
Cerebellum/Cerebrum connections
- Midbrain via the superior cerebellar peduncle
- Pons via the middle cerebellar peduncle
- Medulla via the inferior cerebellar peduncle
Cerebellum: Vasculature
- Arterial supply:
- Superior cerebellar arteries (from basil)
- Anterior and posterior inferior cerebellar arteries (basil and vertebral)
- Venous drainage:
- Occipital venous sinus
Cerebellar: Relations
- Anterior: 4 th ventricle
- Posterior: cisterna magna
- Superior: occipital lobes
- Inferior: basiocciput
- Lateral: cerebella-pontine angle cisterns
Cerebellar Variants
- Variable blood supply
- Megacisterna magna
- Tonsilar ectopia / Chiari malformation
- Agenesis
Corpus Callosum: Description
- The corpus callosum is the largest white matter tract in the brain
- Function: Interhemispheric communication
- Location: Between the cerebral hemispheres above the septum pellucidum
Corpus Callosum: Gross Anatomy
- C-shaped – concave up
- 10cm in length
Divisions:
- Rostrum anterior and inferior part (anterior hook of the c) continues as the copula then lamina terminalis
- Genu most anterior part (elbow like bend), location of forceps minor
- Body largely linear most superior part
- Splenium most posterior part location of forceps major
Corpus Callosum: Vasculature
- Arterial supply:
- Anterior and posterior pericallosal arteries (From ACA and PCA)
- Subcollosal artery
- Veins:
- Anterior and posterior pericallosal veins draining into the deep cerebral veins
Corpus Callosum: Relations
- Superior: Interhemispheric fissure, indusium griseum, falx cerebri, cingulate gyrus, callosal sulcus
- Inferior: septum pellucidum anteriorly and the body of the fornix posteriorly
- Lateral: corona radiata
- Anterior: Frontal lobes, fornix anterior
- Posterior: occipital lobes, fornix posterior
Corpus Callosum: Variants
- Agenesis/dygenesis of the corpus callosum
- Cavum septum pellucidum
- Cavum et vergae
- Cavum veli interpositi
Internal Capsule: Description
- The internal capsule is a deep subcortical structure that contains a concentration of white matter projections.
- Function: Transmision of the motor and sensory information to and form the cortex and the rest of the CNS
Internal Capsule: Gross anatomy
- Divided into 5 parts:
- Anterior limb: lies between the head of the caudate nucleus medially and the lentiform nucleus laterally. Contain thalamic radiations.
- Genu: Medial to the apex of the lentiform nucleus. Contains corticobulbar tracts.
- Posterior limb: between the thalamus and the lentiform nucleus. Contains corticospinal tracts.
- Retrolentiform: behind the lentiform nucleus. Contains optic radiation.
- Sublentiform: below the lentiform nucleus. Contains the auditory radiation.
Internal Capsule: Vasculature
- Arterial:
- Perforators from the MCA and ACA
- Lenticulostriatal and recurrent artery of Heubner.
- Internal carotid supplies the posterior limb
- Venous:
- Internal cerebral vein
- Inferior sagittal sinus
- Posterior vein of the corpus callosum
Temporal Lobe: Description
The temporal lobe is one of four lobes of the brain and largely occupies the middle cranial fossa
Function: Memory formation, communication
Temporal lobe: Gross Anatomy
- Gross anatomy:
- Second largest lobe (after the frontal lobe)
- Borders:
- Superiorly – Sylvian fissure
- Posteriorly – imaginary parietotemporal line
- The middle cranial fossa forms its anterior and inferor boundaries
- The temporal lobe can be divided into two main sections:
- Neocortex – lateral and inferolateral surfaces
- Mesial temporal lobe – hippocampus, amygdala, parahippocampal gyrus
- The temporal lobe is divide into five gyri, from superolateral to inferomedial:
- Superior temporal gyrus – containing Wernicke’s area
- Middle temporal gyrus
- Inferior temporal gyrus
- Fusiform gyrus
- Parahipocampal gyrus (anterior) lingual gyrus (posterior)
Temporal Lobe: Vasculature
- Arterial supply:
- Anterior choroidal
- Middle cerebral
- Basilar
- Venous drainage:
- Superficial middle cerebral vein
- Inferior anastomotic vein of Labbe
- Posterior choroidal vein
Temporal Lobe: Variants
Wernicke’s area can be on either side, most commonly the left
Frontal lobe: Description
The frontal lobe is by far the largest of the four lobes of the cerebrum (along with the parietal lobe, temporal lobe, and occipital lobe), and is responsible for many of the functions which produce voluntary and purposeful action.
Frontal Lobe: Gross Anatomy
The frontal lobe is the largest lobe accounting for 41% of the total neocortical volume. The frontal lobe resides largely in the anterior cranial fossa. Its most anterior part is known as the frontal pole, and extends posteriorly to the central (Rolandic) sulcus which separates it from the parietal lobe.
Posteroinferiorly it is separated from the temporal lobe by the lateral sulcus (sylvian fissure), although not seen from the surface is the insular cortex which is hidden deep to the lateral sulcus
The interhemispheric fissure separates its medial surface from the contralateral frontal lobe.
The frontal lobe is roughly pyramidal in shape, with three cortical surfaces:
- Lateral surface (largest)
- Medial (inter-hemispheric) surface
- Inferior surface
Frontal Lobe: Lateral surface
- Gyri:
- superior frontal gyrus
- middle frontal gyrus
- inferior frontal gyrus
- precentral gyrus (primary motor area)
- Sulci:
- superior frontal sulcus
- inferior frontal sulcus
- precentral sulcus
Frontal lobe: Medial Surface
The medial surface of the frontal lobe, abutting the falx in the midline, is primarily divided by the curving cingulate sulcus, which parallels the outer outline of the corpus callosum.
Above the cingulate sulcus is the medial continuation of the superior frontal gyrus
which is usually divided into two parts by a short ascending branch from the cingulate sulcus.
- medial frontal gyrus
- paracentral lobule
Frontal lobe: Inferior surface
Gyrus recti medially
Orbital gyri arranged in a H configuration (Medial, lateral, anterior and posterior orbital gyri)
Frontal Lobe: Relations
- anterior: frontal bone
- superiorly: frontal bone (anteriorly), coronal suture, and parietal bone (posteriorly)
- posterior: central sulcus and parietal lobe
- inferolaterally: lateral sulcus and temporal lobes
- inferior: floor of anterior cranial fossa
Frontal lobe: Arterial supply
- middle cerebral artery (MCA): lateral frontal lobe
- anterior cerebral artery (ACA): medial frontal lobe
Occipital lobe: Description
The occipital lobe is the smallest of the four lobes of the brain.
Location: Posterior to the temporal and parietal lobes, sitting on top of the tentorium
Function: Primary and secondary visual cortex
Occipital Lobe: Gross anatomy
- Triangular in shape
- Separated from the parietal and temporal lobes by the parieto-occipital sulcus and the parietotemporal line
- Medially it is devided into hemisphere by the longitudinal fissure
- The calcarine sulcus runs horizontally across with the cuneus above and the lingual gyrus below
Occipital lobe: Functional areas
- Primary visual cortex – primary visual processing
- Secondary visual cortex – visual association
Occipital Lobe: Relations
- Anterior: parietal and temporal lobes
- Posterior: occipital bone
- Superior: Parietal lobe and parietal bone
- Inferior: tentorium cerebelli
- Medial: transverse sinuses, confluence of sinuses, straight sinus
Occipital lobe vasculature
- Arterial supply:
- Branches of the posterior cerebral artery
- Venous:
- Straight sinus
- Superior sagittal sinus
- Transverse sinuses
Parietal Lobe: Description
The parietal lobe is one of the four lobes of the brain located between the frontal and occipital lobes.
Function: Sensory processing, communication, proprioception
Parietal Lobe: Gross Anatomy
- Lobe extends from the central sulcus anteriorly to the parieto-occipital fissure posteriorly.
- The lateral sulcus corresponds to its inferolateral boundary, separating it from the temporal lobe. Divided by the medial longitudinal fissure
Gyri:
- postcentral gyrus (primary sensory area)
- superior parietal lobule
- inferior parietal lobule (Wernicke’s area)
Parietal Lobe: Relations
- Anterior: frontal lobe
- Posterior: occipital lobe
- Superior: parietal bone
- Inferior: temporal lobe
Parietal lobe: Vasculature
- Blood supply:
- middle cerebral artery (MCA)
- anterior cerebral artery (ACA): medial parietal lobe
- posterior cerebral artery (PCA): posterior medial parietal lobe
- Venous:
- Superior sagittal sinus
- Straight sinus
- Inferior superficial cerebral vein (Labbe)
Insula lobe: Description
Small deep paired lobe of the brain, covered by the frontal, parietal and temporal opercula (lids).
Function:
- The insula has a number of disparate functions, serving as the primary gustatory cortex, as well as having important connections to language and visual-vestibular integration. Additionally, it also has important autonomic function, particularly sympathetic tone from the right insula; damage to this area has been associated with cardiac arrhythmias.
Insula lobe: Gross Anatomy
- Deep to the lateral sulcus (Sylvain fissure)
- The insula is shaped like a irregular pyramid, with its trapezoid base facing medially.
- The base is circumscribed by the circular sulcus, although, more precisely, it is bounded by four peri-insular sulci: anterior, inferior, superior, and posterior 3-4.
- The apex points laterally into the Sylvian fissure.
- The insular cortex is divided into two lobules, anterior and posterior, by the central sulcus of the insula, which passes obliquely from posterosuperior to anteroinferior.
Insula: Arterial Supply
The insula is supplied by perforating branches from the middle cerebral artery (MCA), usually from the M2 segment.
Circle of Willis: Description
The circle of Willis is an arterial polygon that supplies the brain
Location: Suprasellar cistern around the pituitary infundibulum
Function: Anastomotic supply of oxygenated blood to the brain
CoW: Gross Anatomy
Dividable into anterior and posterior circulations
CoW: Anterior Circulation
Supplied by the internal carotid arteries
Branches:
- Middle cerebral arteries
- Anterior cerebral arteries
- Anterior communicating artery
Cerebral meninges: Description
There cerebral meninges are the coverings of the brain
Function:
Protect the brain, circulation of CSF, venous return
Cerebral meninges: Gross Anatomy
3 layers in total:
- Dura mater – outer most, has outer endosteal layers and inner meningeal layers, folds of the dura mater make the dural venous sinuses, also known as the pachymeninges
- Arachnoid mater – diffuse fibrous middle layer, CSF space is deep to the arachnoid mater, does not extend in the sulci
- Pie mater – closely adhered to the brain very thin, extends into the sulci
Cerebral meninges: Neurovasculature
Arterial supply:
- Anterior meningeal arteries
- Middle meningeal arteries
- Posterior meningeal arteries
Venous drainage:
- Multiple unnamed veins into the dural venous sinuses
Dural venous sinuses:
- Superior and inferior sagittal sinuses
- Straight sinus
- Transverse sinuses
- Sigmoid sinuses
- Sphenoparietal sinus
- Superior and inferior petrosal sinuses
- Cavernous and anterior and posterior intercavernous sinues
Innervation:
Meningeal nerves branches of the:
- Trigeminal nerves
- Glossopharyngeal nerves
- Vagus nerves
Lymphatics:
Deep cervical
Cerebral meninges: Variants
- Mega cisterna magna
- Absence of the confluence of sinuses
- Arachnoid cysts
- Dural calcifications
Ventricles: Description
The cerebral ventricular system is a system of cerebraospinal fluid spaces connected by formaminae.
Function: Circulation of cerebrospinal fluid
Ventricles:Gross anatomy
Contains 20-25ml of CSF in normal adult
2 lateral ventricles, 3rd ventricle and a forth ventricle
Lateral Ventricle
- One in each cerebral hemisphere
- Each has a frontal horn, body, temporal horn and an occipital horn
- Each communicates with the third ventricle by means of an interventricular foramen (of Munro) at the junction of the anterior horn and body
- Contains the choroid plexus which produces CSF
- Frontal horn relations
- roof: corpus callosum (rostrum / genu)
- lateral: caudate nucleus
- medial: septum pellucidum
- Body relations
- roof: corpus callosum body
- medial: septum pellucidum
- floor: thalamus
- Temporal horn relations
- lateral: tapetum of the corpus callosum
- roof: tail of caudate nucleus, amygdaloid nucleus
- floor: hippocampus
- Occipital horn relations
- lateral: tapetum of corpus callosum
- floor: collateral sulcus
3rd Ventricle
- The third ventricle is a slit-like cavity between the thalami
- Sometimes the thalami are connected to each other, forming the interthalamic adhesion
- Relations
- lateral: thalamus
- floor: hypothalamus
- roof: anterior commissure, body of fornix
- anterior: lamina terminalis
- Has several recesses:
- supra-optic recess (above the optic chiasm)
- infundibular recess (above the pituitary stalk)
- posteriorly there is a pineal and suprapineal recesses
- Choroid plexuses of the third ventricle invaginates the roof of the ventricle
- Cerebral aqueduct is the narrow channel in the midbrain that connects the third and fourth ventricles
Fourth Ventricle
- Extends from the cerebral aqueduct (of Sylvius) to the obex and is filled with CSF
- Relations:
- roof: cerebellum
- floor (ventrally): rhomboid fossa (formed by the back of the pons and medulla oblongata)
- lateral walls: cerebellar peduncles
- CSF enters the ventricle via the cerebral aqueduct and leaves via one of four routes:
- via the obex and into the central spinal canal
- via the median aperture (of Magendie) into the cisterna magna
- via ones of the two lateral apertures (of Luschka) into the cerebellopontine cistern
Choroid plexus
Small vascular organs located in all ventricles except the anterior and occipital horns of the lateral ventricles, produce CSF, arterial supply anterior and posterior coroidal arteries
Ventricle: Variant anatomy
- Cavum septum pellicidum
- Cavum vergae
- Cavum veli interpositi
- Interthalamic adhesion may not be present
Pituitary Gland: Description
The pituitary gland is the main exocrine interface between the central nervous system and the rest of the body
Pituitary gland: Gross anatomy
Location: with the sella turcica
Dividable into anterior and poster components:
Anterior pituitary
The anterior pituitary is surrounded by a thin fibrous capsule with thin septa extending into the gland
Parts:
- Pars distalis – arises from the anterior wall of the Rathke’s pouch
- Pars tuberalis – surrounds the anterior aspect of the infundibular stalk
- Pars intermedia – thin epithelial layer between the pars distalis and the neurohypophysis
Hormones produced – GH, FSH, TSH, ACTH, LH, FSH, Prolactin
Blood supply: Portal system supplied by the superior hypophyseal artery (ophthalmic portion of the internal carotid artery)
Posterior pituitary
Direct extension from the hypothalamus
Does not synthesise but releases ADH and oxytocin which has travelled down the stalk via herring bodies from the supraoptic and paraventricular nucleus of the hypothalamus
The infundibular stalk is considered part of the posterior pituitary
Blood supply: Inferior hypophyseal network primary supplied by the inferior hypophyseal artery (from the meningohypophyseal trunk)
Pituitary gland: Relations
- Inferior – sphenoid sinus
- Anterior – clinoid process and anterior intercavenous sinus
- Laterally – the cavernous sinuses
- Superior – the diaphragma sellae and the suprasellar cistern
- Posterior – posterior intercavernous sinus and dorsum sellae
Pituitary gland: Variants
- Hypoplasia
- Empty sella
- Duplication
Pons: Description
The pons is the middle of the three parts of the brainstem, sitting above the medulla and below the midbrain. It acts as a relay between the cerebellum and cerebral hemispheres.
Pons: Gross anatomy
The pons has a bulbous shape and has two main components - the ventral pons and the dorsal tegmentum.
Ventral Pons
The ventral pons consists of white matter tracts (corticospinal, corticobulbar and corticopontine tracts) with transverse fibres contributing to the bulk of the pons.
Dorsal Tegmentum
The dorsal tegmentum is continuous with the tegmentum of the medulla and the midbrain. It contains multiple white matter tracts (medial longitudinal fasciculus, medial lemniscus, lateral lemniscus) and grey matter nuclei (cranial nerves). Within the dorsal tegmentum lie four cranial nerve nuclei:
- trigeminal nerve (CN V): many motor, sensory and mesencephalic nuclei extending from the pons to the upper cervical cord
- abducens nerve (CN VI): motor nucleus
- facial nerve (CN VII): including superior salivary, motor and solitary tract nuclei
- vestibulocochlear nerve (CN VIII): including vestibular and cochlear nuclei
Posteriorly, the pons is connected to the cerebellum by the middle cerebellar peduncle.
Pons: Relations
- Anteriorly: prepontine cistern (contains CN V & VI)
- Laterally: cerebellopontine angle cistern (contains CN VII & VIII)
- Posteriorly: fourth ventricle (the pons makes up the anterior wall)
- Superiorly: continuous with the midbrain
- Inferiorly: continuous with the medulla
Pons: Vasculature
Arterial:
- medial branches of the superior cerebellar artery
- pontine branches of basilar artery
Venous:
- Lateral and transverse pontine veins
Pons: Variants
- Basilar artery fenestration
- Pontine artery branches from the superior cerebellar artery or anterior inferior cerebellar artery
Thalamus: Description
The thalamus is the largest structure of the diencephalon
Function: Relay centre, consciousness, sleep and memory
Thalamus: Gross anatomy
- Composed of 2 symetrical egg shaped masses which are typically connected midline by the interthalamic adhesion.
- The grey matter of the thalamus is divided by a y shaped layer of white matter called the internal medullary lamina. This divides the thalamus into anterior, medial and lateral parts.
- The thalamus contains over 50 distinct nuclei.