Neuro Flashcards

1
Q

seizures

A

seizures - excitatory activity in the cortex

cortical dysplasia - congenital, seizure focus

absence - …, simple automatisms present (eyelid fluttering, lip smacking), easily provoked by hyperventilation

  • 3Hz spike on EEG
  • NO post-ictal phase
  • comorbidities - (inattentive) ADHD, anxiety
    - treat ADHD with methylphenidate and atomxetine (non-stimulant)
  • YES provoked by hyperventilation
  • treat - ethosuximide

focal seizures

  • may generalize
  • can have impairment of consciousness
  • automatisms - involve both hemispheres (are seen in focal seizures with impairment of consciousness)
  • NOT provoked by hyperventilation

temporal lobe epilepsy

  • olfactory aura or deja vu
  • affective sxs - rising sensation in stomach
  • pie in the sky visual loss (left superior quadrant loss) will be on opposite side of lesion- Meyer loop

juvenile myoclonic epilepsy
- generalized seizure, most commonly myoclonic jerks after the first hour after awakening

Lennox- Gastaut - presents by age 5

  • ID, severe seizures
  • slow spike-wave pattern on EEG

Sturge-Weber syndrome

  • seizures, ID, nevus in trigeminal territory (represents congenital unilateral cavernous hemangioma)
  • other findings - hemianopia, hemiparesis, hemisensory disturbance
  • ipsilateral glaucoma
  • tramline intracranial calcifications

1) CT (urgent situation) or MRI (elective situation) should be performed in all pts with an apparent unprovoked seizure
- MRI is more sensitive in identifying most structural causes of epilepsy - temporal sclerosis, cortical dysplasia, vascular malformations, TBI, infarct, tumor, infection

2) EEG

hypocalcemia - severe will cause tetany and seizures
- but note in DiGeorge - this will occur in the newborn period only (overtime, compensatory parathyroid hyperplasia occurs…)

hypoglycemia

hyponatremia

Todd paralysis - transient limb weakness following partial seizure activity
- hemiplegia
(- pathophys is unknown - but though to involve neuronal exhaustion/inhibition in the postictal period)

status epilepticus - historically single seizure that lasts longer than 30 min

  • recent study - brain that has seized for >5 min is at increased risk for developing permanent injury (due to excitatory cytotoxicity)
  • cluster or seizures with pt normal recovering normal mental status in between
  • increased risk of cortical laminar necrosis - cortical hyperintensity on diffusion-weighted imaging (=infarct)
  • give lorazepamx2, thiamine, and glucose
    - fosphenytoin (IV version)
    - then can try phenobarb, other anti-epileptics - this is considered refractory status epilepticus

lamictal - good for prevention of primary generalized seizures AND partial seizures

dopamax

valproate - side effects include hair loss, tremor, TCP
- neural tube defects, dysmorphic facies

phenytoin

  • drowsiness, diplopia, ataxia - and long-term bad side effects if used in young people
  • gingival hyperplasia, SJS-TEN
  • fetal hydantoin syndrome - facial and cardiac defects
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

tuberous sclerosis

A

intellectual disabilities, behavioral problems, epilepsy

adenoma sebaceum - appears between 5-10yrs of age

cardiac rhabdomyomas, renal angiomyolipomas, facial angiofibromas, hypopigmented macules (ash leaf spots)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

narcolepsy

A

daytime sleepiness, hypnagogic hallucinations, sleep paralysis (inability to move soon after awakening), cataplexy

treat with sleep hygiene, scheduled naps, modafinil (promotes wakefulness)

note - sedating drugs (alcohol, benzos, antipsychotics) should be avoided in pts with narcolepsy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tourettes

A

kids may have OCD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

neurofibromatosis

A

type 1: AD

  • cafe-au-lait macules
  • neurofibromas - skin exam yearly (some lesions may undergo malignant transformation)
  • lisch nodules (tan hamartomas of iris)
  • other - optic gliomas, macrocephaly, feeding problems, short stature, learning disabilities, clustered freckles (axillary)

type 2:
bilateral acoustic neuromas, cataracts, meningiomas, ependymomas

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Wilsons disease

A

AR

child and adolescents - liver disease (asymptomatic transaminitis to fulminant liver failure)

young adults - neuropsych disease (tremor, rigidity, depression, paranoia, catatonia)

ddx by low serum ceruloplasmin < 20 mg/dL + increased urinary Cu excretion

  • Kayser-Fleischer rings
  • atrophy of lenticular nucleus

can see Mallory hyaline bodies on liver bx (but generally, this is more suggestive of alcohol liver injury)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

multiple sclerosis

A

Uhthoffs phenomenon - symptoms worsen with exposure to high temps

bilateral internuclear ophthalmoplegia

  • only one eye is able to abduct - affected eye (ipsilateral) is unable to adduct to follow
  • damage to heavily myelinated fibers of the MLF

if you suspect - get MRI (T2)
- LP for oligoclonal IgG bands afterwards, esp if dx is not clear

acute exacerbation - treated with glucocortiocids (IV methylprednisolone)

  • plasmapheresis in pts refractory to steroids
  • acute exacerbation will last day-weeks

optic neuritis - subacute painful vision loss (in 1 eye) with abnormal pupillary response to light in affected eye (APD, Marcus Gunn pupil)

  • ddx by MRI of orbits and brain
  • fundoscopy is normal as inflammation occurs behind optic nerve head
  • common initial presentation of MS

segmental demyelination/inflammation = tranverse myelitis - can occur with MS

  • subacute onset of flaccid paralysis (due to spinal shock), loss of ALL sensation below level of injury (typically occurs in thorax)
  • get spinal MRI

CSF findings - mild CSF pleocytosis (increased WBC counts)
- protein is nl to mildly elevated

disease modifying agents - INFB, natalizumab (and other -mabs), glatiramer acetate, fingolimod, dimethyl fumarate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

drugs you DONT use in the elderly

A

benzos - linked to confusion and falls, paradoxical agitation (will be seen w/i an hour of the dose)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Trinucleotide repeats

A

Friedreich ataxia

AR - due to GAA repeats –> abnormality in frataxin protein
- genetic counseling for future pregnancies

limb and gait ataxia (broad based gait), loss of reflexes, loss of vibratory and position sense

  • most pts wheelchair bound by 25
  • death by 30-35

CV - necrosis and degeneration of cardiac muscle fibers, may see abnormalities on EKG
- can have cardiac arrhythmia –> death

Huntingtons - AD
- atrophy of caudate and putamen, enlargement of lateral ventricles (box car ventricles)
- chorea, athetosis (slow, writing movements of hands and feet)
- mood disturbances

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

neuroblastoma

A

median age - 2yo

derived from neural crest cells

  • firm, nodular mass located in abdomen usu - adrenals or retroperitoneal ganglia
  • calcifications and hemorrhages seen on imaging

70% of pts will have metastatic dz when diagnosed - long bones, skull, bone marrow, liver, LNs, skin

urine HVA an VMA are elevated

Wilms tumor - from metanephros

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

syringomyelia

A

anterior commissure, then anterior gray horn (LMN damage) - damage involves crossing fibers of spinothalamic tract (pain and temp) and upper extremity motor fibers
- preservation of DCML (light touch, vibration, position sense)

associated with Arnold Chiari malformations (type 1), prior spinal cord injuries (whiplash injury), inflammation, infection, tumor

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

cervical spondylosis

A

pts > 40 - due to disc herniation

sxs - neck pain and stiffness, signs of radiculopathy and myelopathy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

syncope

A
  • neurocardiogenic* aka vasovagal - prolonged standing, emotional distress, painful stimuli
  • prodrome - nausea, warmth, diaphoresis
  • excess vagal tone - profound hypotension and bradycardia

situational - cough, micturition, defecation

orthostatic
- clues are that this doesnt occur when lying down

aortic stenosis, HCM, anomalous coronary arteries - syncope with exertion or exercise
- dyspnea, CP, fatigue on exertion

v. arrhythmias - hx of CAD, MI, cardiomyopathy, or decreased EF

sick sinus syndrome, brady, AV block - sinus pauses, increased PR or increased QRS duration

Torsades - hypoK, hypoMg, prolonged QT (meds)

Congenital long QT - fhx of sudden death, long QT, syncope with triggers (exercise, startle, sleeping)

TIAs that affect posterior circulation and brain stem can cause syncope - rare

can have seizure like activity during syncope - but this is considered nonepileptic in nature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

vitamin issues/absorption issues

A

subacute combined degeneration

  • degeneration of dorsal and lateral spinal tracts - B12 deficiency
  • progressive symmetric sensory loss, impaired proprioception/vibration, sensory ataxia
  • late - spastic muscle weakness
  • can have UMN signs
  • get serum MMA levels

d-lactic acidosis - occurs in pts with short bowel syndrome

  • unabsorbed carbs, intestinal bacteria –> d-lactic acid –> absorbed
  • usu asx but can get confusion, ataxia, and dysarthria with carb loading
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

anterior spinal cord syndrome

A

flaccid paralysis (due to spinal shock)

  • loss of pain/temp below level of injury (STT affected)
  • bilateral hemiparesis - LCST affected
  • can have autonomic dysfunction

risk factors - aortic dissection, surgery, trauma (injury to anterior spinal artery, due to disc retropulsion, vertebral burst fracture)

get MRI

treatment
- decompression procedure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

sellar mass

A

benign - pituitary adenoma, craniopharyngioma (Rathke’s pouch, kids), meningioma, pituicytoma
- craniopharyngioma - cystic structures with calcifications

malignant tumors - primary (lymphoma, etc.), mets (breast, lung)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

glaucoma

A

open-angle - gradual loss of peripheral vision in both eyes –> tunnel vision
- increased cup:disc ratio

acute angle closure

  • due to impaired drainage of aqueous humor into anterior chamber
  • sudden onset pain and redness (conjunctival injection) of one eye, nonreactive mid-dilated pupil
  • can see halos around lights
  • spontaneous, triggered by meds (decongestants, antiemetics, anticholinergics like trihexyphenidyl used in Parkinsons, or tolterodine)
  • tonometry –> gonioscopy (psrimatic lens to visualize iridocorneal angle)
  • treat - pressure-lowering drops, laser/surg interventions

congenital glaucoma - sensitivity to light, excessive lacrimation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

pseudotumor cerebri (IIH)

A

obese women, <45 yo, meds (tets, vitamin A excess, GH, steroids, OCPs)

headache (worse when lying flat), transient visual symptoms (can be vision loss), pulsatile tinnitus, diplopia

papilledema, visual field loss, sixth nerve palsy

MRI (to look for mass or hemorrhage) +/- MRV (to look for cerebral vein thrombosis)

  • note empty sella is present in 70% of pts
  • LP with opening pressure > 250 mm H2O

treat with acetazolamide (weight loss, stop offending meds)

if left untreated - risk of blindness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

cerebral palsy

A

nonprogressive motor dysfunction

1) spastic
2) dyskinetic
3) ataxic

spastic diplegia - see in premies

  • hypertonia, hyperreflexia in LE
  • feet are down and in (equinovarus)
  • clasp-knife rigidity

risk factors - prematurity (before 32 wks), IUGR, intrauterine infection, antepartum hemorrhage, placental pathology, multiple gestation, mat alcohol consumption, mat tobacco use

treat with - therapy, baclofen or botox for spasticity

comorbidities - ID, epilepsy, strabismus, scoliosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

ICP

A

causes - brain parenchyma, CSF, blood

headaches worse in the morning

papilledema - enlarged blind spot

  • can cause momentary vision loss that varies according to head position
  • can rapidly lead to permanent vision loss

reducing ICP - head elevation, IV mannitol, hyperventilation, removal of CSF, sedation (decreases metabolic demand, controls HTN)

  • side note
    - vent rate affects pCO2
    - pO2 - affected by inhaled O2 or end-exp pressure

uncal herniation - CN3 palsy + ipsilateral posterior cerebral artery compression (contralateral homonymous hemianopsia)
- compression of reticular formation –> altered level of consciousness, coma

cushings reflex - HTN, bradycardia, respiratory depression
- concerning sign of brainstem compression

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

hydrocephalus

A

infants

  • poor feeding, irritability, decreased activity, vomiting
  • bulging fontanelle, prominent scalp veins, widely spaced sutures, rapidly increasing head circumference

get CT

VP shunt

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

vertigo

A

BPPV - calcium crystals in semicircular canals
- room spinning when turning head, nystagmus, nausea

infarct of medial vermis of cerebellum - vertigo, nystagmus

lateral cerebellar infarct - dizziness, ataxia, weakness, tendency to sway TOWARDs lesion

Menieres - excess endolymphatic fluid in inner ear

  • triad of episodic dizziness, low-freq hearing loss, tinnitus
  • can have significant vertigo that lasts for days
  • treat with salt restriction and diuretics

vertebrobasilar insufficiency - vertigo + dysarthria, diplopia, numbness

AG tox:
ototoxicity

vestibulopathy - pts dont experience vertigo because there is no left/right imbalance

  • both vestibular organs are affected equally
  • head thrust test is abnormal - head moves away from target –> eyes move away from target and horizontal saccade back

oscillopsia - objects moving around in visual field
- gait disturbances

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

dementia

A

normal aging - mild cognitive impairment (no interference with daily activities) - dementia

pts with cognitive decline –> neurocognitive testing = MMSE
- MMSE <24 is dementia
- 20-24 = mild dementia
- 13-20 = moderate dementia
<12 = severe dementia
- THEN perform thyroid function and B12 levels

Alzheimers disease most common dementia in US) - linked to a loss of cholingeric neurons

  • amyloid plaques
  • memory loss first, insidious
  • lang deficits, spatial disorientation, late personality changes, myoclonus, seizures, urinary incontinence
  • psychotic features may appear in the middle of the disease course - delusions are commo
  • life-expectancy of 3-8yrs after diagnosis
  • dx requires 2 or more areas of cognitive defects
  • CT will show atrophy - more prominent in parietal and temporal lobes, hippocampi (mesial temporal atrophy)
  • treat with AchEI - donepezil, galantamine, rivastigmine
  • memantine (NMDA antagonist) - approved for mod-severe dementia

Vascular dementia

  • stroke event may be described as a fall
  • stepwise decline
  • early executive dysfunction
  • cerebral infarct (hypodense), deep white matter changes (from chronic ischemia)

FTD (Picks)

  • early personality changes, disinhibition (including disinhibition of primitive reflexes, so they may be present on exam)
  • language changes
  • late - mute, immobile, incontinent

Lewy body

  • visual hallucinations (sees kids or animals), spont parkinsonism (symmetric and rigidity, whereas parkinsons will have unilateral effects), fluctuating cognition, visuospatial dysfunction (falls)
  • memory loss is late
  • eosinophilic intracytoplasmic inclusions - a-synuclein
  • tx - cholinesterase inhibitors
  • dont give typical antipsychotics - because these pts may exhibit neuroleptic hypersensitivity

NPH - wet, wobbly, wacky

  • cause is diminished CSF absorption or obstructive hydrocephalus
  • normal opening pressure on LP
  • initially large volume LPs –> VP shunt

Prion (CJD) - sporadic, rapid progression, startle myoclonus, behavioral changes

  • other features - akinetic mutism, cerebellar or visual disturbance, hypokinesia
  • periodic sharp triphasic wave complexes on EEG and/or pos 14-3-3 CSF assay
  • definitive ddx by brain bx findings (spongiform changes) or demonstrated PRNP gene mutations
  • end-stage - people lose the ability to move and speak –> coma
  • death w/i 1 yr of onset

pseudodementia - cognitive changes assoc with MDD
- concerning - weight loss and social isolation, sleep changes

polypharmacy, OSA, electrolyte disturbances, anemia

work-up - CBC, CMP, meds that they are on, TSH, B12 (treat anything below 400), MRI (get w/ and w/o contrast)

  • others - CSF studies, ESR, PET, RPR, UA
  • travel hx - Lyme disease for people who have traveled to the NE US
  • AAN work-up - recommends neuroimaging, screening for depression, hypothyroidism, and B12 deficiency

side note - treatment options are poor for dementia
- and treatment does not change prognosis

avoid antipsychotics (atypical and typical), can give a tiny bit of haldol, mood stabilizers are good if pt becomes aggressive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

myasthenia gravis

lambert eaton

dermatomyositis/polymyositis

A

all three are paraneoplastic syndromes

myasthenia:
presents earlier in women - 20s-30s, men 60s-80s
- antibody against nicotinic Ach receptor - lesion considered in the motor endplate
- px - ocular (diplopia), bulbar (dysarthria, dysphagia), symmetric proximal weakness
- myasthenia crisis - precipitated by surgery (esp thymectomy interestingly enough), anesthetics, infection, meds (Ags, b-blockers), pregnancy/childbirth
- sxs - generalized and oropharyngeal weakness, respiratory insufficiency/dyspnea
- during a crisis - hold pyridostigmine in order to reduce excess airway secretions and aspiration risk
- tx - intubate, plasmapheresis/IVIG and corticosteroids
- monitor vital capacity and max inspiratory force

ddx

  • edrophonium/tensilon test (AchE inhibitor, immediately improves symptoms), ice pack tests (ice pack will relieve ptosis)
  • AchR antibodies - highly specific
  • CT scan - thymoma

treat
1) AchE inhibitors -
pyridostigmine
2) immunotherapy (cyclosporine), thymomectomy

Lambert-Eaton syndrome - diminished/absent DTRs
- symmetric proximal limb weakness, autonomic dysfunction
- assoc with small cell lung cancer
- treat with guanidine or 3,4-diaminopyridine (can add IVIG/immunosuppressants)

dermatomyositis/polymyositis
- symmetrical + proximal muscle weakness
- reflexes will be normal (other than in a diabetic.. confounds exam)
- other findings - ILD, esophageal dysmotility, Raynaud phenomenon
- polyarthritis
- skin findings in dermatomyositis - Gottrons papules (violaceous plaques, scaly, overlie MCP), heliotrope rash
- mediated by cytotoxic T lymphocytes
- dx - elevated CPK, aldolase, LDH (get EMG and bx in cases of uncertainty)
- tx - high-dose glucocorticoids + glucocorticoid sparing agent + screen for malignancy (age related)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

ALS

A

UMN and LMN disease - asymmetric limb weakness and bulbar dysfunction
- bulbar (medulla) dysfunction - dysfunction of CNs 9-12 (glossopharyngeal, vagus, accessory spinal, hypoglossal)

riluzole - glutamate (release) inhibitor, prolongs survival
- side effects - dizziness, N, elevated LFTs

death within 5 yrs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

spinal cord injury

A

cord compression = medical emergency

  • causes - spinal injury (disk herniation, compression fracture), malignancy (lymphoma, breast cancer mets), infection (epidural abscess)
  • severe low back pain, worse in the recumbent position at night - due to distention of epidural venous plexus when lying down
  • early - bilateral, LE weakness and absent DTRs
  • late - UMN signs, paraplegia, bowel/bladder dysfunction
  • reasons - descending CSTs affected (LE weakness, loss of rectal tone), ascending spinothalamic tract (sensation), descending autonomics (reticulospinal tract, urinary RT)
  • emergency MRI of spine, IV glucocorticoids, rad-onc/surg consults

central cord syndrome

  • hyperextension injury in elderly pts with pre-existing degenerative changes in c-spine (fall, whiplash)
  • damage to central portion of anterior spinal cord - CST and LST
  • weakness in upper extremities (because these correlate with the central part of the CST)
  • can have loss of pain and temp in arms (due to damage to spinothalamic tract)

anterior ventral cord syndrome

  • occlusion of ASA
  • bilateral spastic motor paresis distal to lesion

Brown-sequard - hemisection of cord due to penetrating injury
- ipsilateral - weakness (LCST), spasticity, loss of vibration sense, and proprioception AT level of injury
- contralateral - loss of pain and temp, 2 levels below injury
- if this occurs in cervical region - can have ipsilateral Horner syndrome
(- compared to complete spinal transection - loss of everything, quadraplegia or paraplegia

posterior cord syndrome

  • causes - MS, vertebral artery dissection
  • bilat loss of vibratory and proprioceptive sensation, weakness, paresthesias
  • urinary incontinence/RT

spinal cord infarct - abrupt symptoms

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

brain bleed

A

ICH - urgent non-contrast CT
- headache, AMS

Intraparenchymal hemorrhage

  • BG (putaminal) hemorrhage - almost always involves internal capsule –> contralateral hemiparesis and hemianesthesia
    - due to hypertensive vasculopathy - involves small penetrating branches –> formation of Charot-Bouchard aneurysms in deep brain structures –> rupture and bleed –> in BG, cerebellar nuclei/cortex, thalamus, and pons
  • AV malformation - most common cause of intraparenchymal bleed in kids
  • symptoms - gradual onset
  • symptoms include - ipsilateral hemitaxia (because corticopontocerebellar fibers decussate twice)
  • spreading hematoma can lead to coma
  • non-con CT and decompression imm

cerebral amyloid angiopathy - most common cause of lobar/cortical hemorrhage (occipital, parietal) in the elderly (age >60)

SAH - CT (and if needed–> get LP)

  • due to berry aneurysms - will see blood collecting in brainstem and basal cisterns
  • thunderclap headache, neuro deficits are UNcommon
  • further evaluation with CT angio

SDH - tearing of bridging veins

  • elderly, alcoholics (cerebral atrophy and increased fall risk)
  • acute - slow bleed into subdural space, confusion is gradual (1-2d), impaired consciousness, increased ICP signs
  • chronic - insidious, onset weeks after injury, somnolence, focal neuro deficits

epidural hematoma

  • bleed doesnt cross suture lines
  • sphenoid bone trauma –> tearing of middle meningeal artery
  • uncal herniation - ispilateral CN3 palsy (down, out, and dilated due to loss of motor and PSNS), hemiparesis
  • ddx by head CT
  • urgent surgical evacuation for symptomatic pts
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

EMG

A

differentiates between nerve and muscle disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

stroke

A

greatest risk factor for both ischemic and hemorrhagic - HTN

  • because it accelerates atherosclerotic process and promotes thrombi formation
  • side note - cerebral amyloid angiopathy is the second most common cause of intracerebral hemorrhage (occurs in age >75)

if you suspect a stroke - get noncontrast CT head

cardioembolic stroke - gray-white junction

  • if due bacterial endocarditis - you have septic embolism, treat with IV abx
  • more sudden onset than atherosclerotic stroke
  • embolic strokes are more likely to bleed than thrombotic strokes

ischemic stroke - hypodense region that will become evident >24hrs after event

  • tpa window - 3.5-4hrs after sx onset (exclusion criteria is long, remember bleeding risk, prior stroke/head trauma in the last 3 mo, and recent intracranial/spinal surgery, BP > 185/110)
  • stroke and not on ASA - add ASA imm
  • stroke and on ASA - add clopidogrel (or dipyridamole)
  • stroke + afib - long term anticoagulation (start outpatient)

ischemic stroke with hemorrhagic transformation - deterioration in pts neurologic status
- get emergent noncon CT –> urgent surgical decompression

intracerebral hemorrhage - focal neuro deficits and signs of increased ICP (vomiting and headache, bradycardia, reduced alertness)
- warfarin-associated intracerebral hemorrhage - give vitamin K and prothrombin complex concentrate (contains factors)

stroke in young
- PFO, IC dissection (trauma!, associated with Horners and varying degrees of hemiparesis), Ehlers-Danlos or Marfans, AVFs, moyamoya disease, drug abuse, hypercoagulable state

tx - lifestyle modification. Start asa, statin, and BP reduction.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Parkinsons

A

accumulation of a-synuclein in substantia nigra (BG) –> death of these neurons

2/4 for clinical ddx - resting tremor, rigidity, bradykinesia (hypokinetic, narrow based gait), postural instability

  • symptoms present asymmetrically…
  • other signs include mask-like facies

tremor - improves with activity (note essential tremor is the opposite)

  • 4-5 Hz frequency
  • starts on one hand before the other
  • treat with trihexyphenidyl (anticholinergic)

rigidity - lead pipe or oscillating

postural instability - flexed axial posture, loss of balance during turning or stopping, loss of balance when pushed from stationary bipedal stance, frequent falls

drugs

  • levodopa/carbidopa - side effect is somnolence and hallucinations
  • entacapone - increases dopamine stimulation, side effect is dyskinesia (and other side effects of excess dopamine)
  • amantidine - dopamine agonist, shown to delay dementia, side effects are ankle edema and livedo reticularis
  • pramipexole - dopamine agonist (also used in restless leg syndrome)
  • selegiline - MAOB inhibitor, side effect is insomnia and confusion
  • note - increased dopamine –> nausea, orthostatic hypotension, dizziness, dyskinesia (long-term use), hallucinations (in order pts)

drug-induced parkinsonism - due to anticholinergics (benzotropine, diphenhydramine)
- side note - anticholingerics can improve tremor and rigidity but not bradykinesia

Shy-Drager syndrome - degenerative disorder

  • parkinsonism
  • autonomic dysfunction (orthostatic hypotension, impotence, incontinence, etc.)
  • widespread neurologic signs (cerebellar, pyramidal, or LMN)
  • treat by intravascular volume expansion (fludrocortisone, salt supplementation, a-agonists, compressive stockings)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

conus medullaris

cauda equina

A

conus medullaris (UMN and LMN sxs)

  • note - things that affect the spinal cord can cause UMN and LMN symptoms
  • back pain with EARLY bladder and rectal dysfunction
  • symmetric motor weakness, hyperreflexia

cauda equina - spinal roots (part of peripheral NS) compressed
- radicular pain, asymmetric LE weakness and hyporeflexia, saddle anesthesia, LATE bowel/bladder dysfunction

causes - cord compression due to mets, disc herniation/rupture, spinal stenosis, infection, tumor, hemorrhage, iatrogenic injury

management - emergency MRI, neurosurg eval
+/- IV glucocorticoids
- neurosurgical emergencies - due to risk of permanent loss of sphincter function

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

torticollis

A

focal dystonia of SCM
- dystonia - sustained muscle contraction –> abnormal movements

torticollis - congenital, idiopathic, trauma, local inflammation, drug-induced (antipsychotics, metoclopramide, prochlorperazine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

tremors

A

essential tremor, AD

  • can affect UE, head, voice, etc.
  • worsens with motion, arms extended, caffeine
  • resolves during sleep, improves with alcohol consumption
  • treat with propanolol (or primidone)
  • orthostatic tremor is a variant of essential tremor - occurs in legs on standing, relieved by sitting down

Parkinsons - resting tremor of extremities
- basal ganglia dysfunction - progressive loss of dopaminergic neurons in basal ganglia

cerebellar (spinocerebellar ataxia, genetic condition) aka intention tremor - usu associated with ataxia (fall towards side of lesion), dysmetria, or gait disorder
- tremor increases as hand reaches target

physiologic

  • low amplitude - 10-12 Hz, not visible normally
  • onset with increased sympathetic activity (drugs, caffeine, anxiety)
  • worsens with movement, can involve face and extremities
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

hemiballismus

A

due to damage of contralateral subthalamic nucleus
(- involved in the inhibition of movements)

thalamic stroke (aka lacunar stroke of thalamus)

  • certain thalamic nuclei transmit sensory information from the contralateral side of the body and face
  • stroke - contralateral (total) sensory loss
  • can also have transient hemiparesis, athetosis, ballistic movements - because neighboring basal ganglia/internal capsule fibers are disrupted
  • weeks to mo after stroke - thalamic pain syndrome (allodynia)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

ID

A

fetal alcohol syndrome

1) small palpebral fissures
2) smooth philtrum
3) thin vermillion border

height, weight often < 10%

microcephaly + cognitive and behavioral disorders - social withdrawal, delays in motor an lang

treatment - early ddx is critical, therapy

DS is most common genetic cause of developmental delay
- flat facial profile, slanted fissures, small low-set ears, clinodactyly, etc.

Fragile X is the most common inherited reason for ID
- XD, CGG repeat
- long narrow face, prominent forehead and chin, large ears, macrocephaly, macroorchidism
- ADHD, autism
- female pts with the mutation may have normal intellect, may have mild ID

Infections
- CMV - ID, sensorineural deafness, blindness, jaundice, HSM, petechiae
- rubella - sensorineural deafness, cataracts, HSM, purpura

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

fetal phenytoin syndrome

A

hypoplastic fingers/nail and cleft lip/palate

give ppx vitamin K in first trimester - phenytoin may increase rate of fetal vitamin K degeneration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

brain injury

A

cerebral contusion - heal without medical intervention

diffuse axonal injury - accel/decel injury

  • coma
  • head CT may show bleeds at grey-white junction

concussion - mild TBI, confusion, amnesia

  • immediately after - rest for 1 day, reassess
  • post-concussive syndrome - headache, confusion, amnesia, difficulty concentrating, vertigo, mood alteration, sleep disturbance, anxiety
    - resolve few weeks to mo following TBI
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Guillain-Barre

A

bugs - Campy (others are Herpes, Mycoplasma, H flu)

ascending polyneuropathy after respiratory tract or upper GI infection

demyelination of the peripheral motor nerves - neuropathic pain

flaccid paralysis, absent DTRs and nerve conduction velocities, severe back pain

  • side note - absent DTRs and paresthesias = signs of NEUROpathy
  • autonomic symptoms (ileus, BP, heart rate instability, orthostatic hypotension)
  • respiratory compromise

CSF - elevated protein, normal cell count = albuminocytologic dissociation
+ use EMG for ddx
- infiltrating T lymphocytes and macrophages around nerver

plasmapheresis and IVIG

  • and monitor autonomic and respiratory function
  • assess pts pulmonary function by serial spirometry (FVC is gold std for assessing ventilation, decline in FVC indicates impending respiratory arrest –> tube)

typically - spontaneous recovery in a year

tick paralysis - neurotoxin in tick saliva –> paresthesias, fatigue, ascending muscle paralysis over hrs or days
- paralysis can be localized to or more pronounced in 1 leg/arm
- examine skin to remove tick –> will result in recovery

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Wallenburg syndrome

A

lateral medullary infarct

  • due to intracranial vertebral artery
  • ddx on MRI
  • give TPA

1) vertigo, falling to side of lesion, nystagmus, ipsilateral limb ataxia
2) abnormal facial sensation, loss of pain and temp in ipsilateral face and contralateral body

3) cranial 9 and 10 involvement - dysphagia, aspiration, hoarseness
(- contrast with lateral mid-pontine lesions - affect motor and principal sensory nuclei of trigeminal nerve)

4) autonomic dysfunction -
ipsilateral Horners syndrome, intractable hiccups, lack of autonomic respiration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

medial medullary syndrome

A

branch occlusion of vertebral or ASA

contralateral paralysis or arm and leg
tongue deviation TOWARDS lesion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

medial mid-pontine infarction

A

contralateral ataxia and hemiparesis of the entire body (face, trunk, limbs)
- variable loss of contralateral tactile and position sense

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

NM weakness

  • UMN
  • anterior horn
  • peripheral nerves
  • NMJ
  • muscle fibers
A

UMN - leukodystrophies, vasculitis, brain mass in cortext, B12 deficiency (DCML)

anterior horn cells
- spinal muscular atrophy, ALS, paraneoplastic syndrome, polio

peripheral nerves

  • hereditary primary motor sensory neuropathy
  • GB
  • diabetes
  • amyloid neuropathy (myeloma)
  • lead poisoning

NMJ

  • MG, LES
  • organophosphate poisoning
  • botulism

muscle fibers

  • muscular dystrophies (waddling gait, weak gluteal muscles)
  • poliomyositis and dermatomyositis
  • hypothyroidism (+ reduced DTRs)
  • corticosteroids
  • HIV myopathy
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

LOC

A

generalized seizures

  • triggers - fever, hypoglycemia, sleep deprivation
  • tongue biting, urinary incontinence, perioral cyanosis
  • preceding aura, LOC, convulsions, post-ictal state

vasovagal syncope

  • prolonged standing, stress
  • presyncope (lightheadedness, pallor, diaphoresis, nausea)
  • IMMEDIATE return to baseline

cardiogenic syncope (decreased CO in the setting of structural HD)

  • exertion, dehydration
  • sudden LOC (no prodrome), immediate return to baseline

v. s. breath-holding spells
- in 6 mo-6yrs
- cyanosis, pallor following an upsetting event or minor injury
- immediate recovery

HOCM (syncope on exertion), orthostatic hypotension (intravascular volume depletion, autonomic instability due b-blockers)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

infective endocarditis

A

cardiac - valvular insufficiency, perivalvular abscess, conduction abnormalities, mycotic aneurysm

neuro - embolic stroke, cerebral hemorrhage, brain abscess, acute encephalopathy or meningoencephalitis

renal - renal infarct, glomerulonephritis, drug-induced interstitial nephritis (from therapy)

MSK - vertebral osteo, septic arthritis, MSK abscess

if you suspect - draw blood cultures, initiate broad-spectrum abx, echo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

cerebellar lesion

A

broad-based gait, impaired heel-to-shin testing

posterior circulation issue

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

neurosyphilis

A

treponema pallidum - spirochetes directly damage the dorsal sensory roots
–> secondary degeneration of the dorsal columns

early - meningitis

late - dementia, tabes dorsalis (sensory ataxia, pos Romberg, lancinating pains, reduced DTRs), Argyll robertson pupils (accommodates but doesnt react), dysmetria (overshoot, undershoot of movements), neurogenic bladder

tertiary syphilis can cause uveitis

other features - decreased concentration, memory loss, dysarthria, tremors, irritability, headaches, personality changes and impaired judgement

treat with IV penicillin for 10-14d

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

PML

A

JC virus –> demyelinating disease
- affects immunocompromised - transplant pts

subacute AMS and multifocal neurologic deficits

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
48
Q

drug overdoses

A

Wernickes encephalopathy - confusion (encephalopathy), horizontal nystagmus, gait ataxia
- due to thiamine deficiency

benzos - binds to GABA receptors

  • slurred speech, ataxia, hypoT, depressed mental status
  • give flumazenil

opioid OD - pinpoint pupils, respiratory depression
- naloxone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
49
Q

sleep

A

normal age-related sleep changes - decreased total sleep time, increased nighttime awakenings, phase advance (sleep earlier, wake up earlier)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
50
Q

headache

A

migraine - due to vasospasm

  • often pos FHx
  • unilateral, pulsatile and throbbing
  • auras (can be paresthesias), photophobia, phonophobia, nausea
  • basilar migraine - can have basilar aura sxs (vertigo, dysarthria, tinnitus, diplopia)
  • abortive - triptan, NSAID, acetaminophen, antiemetics, ergots
    - triptans - serotonin agonist –> vasoconstriction, decreases neurogenic inflammation
  • preventives - topiramate, divalproate, TCADs, b-blockers
    - topiramate - can cause renal stones
    - valproate - hepatotoxic

cluster

  • M>F
  • onset during sleep
  • can occur in paroxysms
  • behind one eye, excruciating, sharp and steady
  • sweating, facial flushing, nasal congestion, lacrimation, pupil changes
  • ppx with verapamil, Li
  • acute attack can be aborted by 100% O2 (or subQ sumatriptan)

trigeminal neuralgia - maxillary and mandibular disorders
- tx - carbamazepine

tension

  • stress, band-like pattern around head, muscle tenderness in head/neck/shoulders
  • temporal and occipital regions
  • use ibuprofen, aspirin, and caffeine to treat

kids - headaches are a common complaint

  • most common = migraines - but will be bifrontal, shorter in duration, other sxs similar
  • occipital headache is CONCERNING
  • treat with supportive management –> triptans
  • image if coordination difficulties, numb/tingling, focal neuro, headache that wakes you from sleep, increasing frequency

when would you image

  • neuro findings - seizures, deficits, changes in consciousness
  • change in nature
  • onset age > 40, sudden onset, trauma, present on awakening
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
51
Q

cancer pain, bony mets

A

mild - acetaminophen, NSAIDS (naproxen has a longer duration than ibu)

moderate - weak opioids and non-opioids
- codeine, hydrocodone, tramadol

severe - short-acting opioids

  • morphine, hydromorphone
  • calculate daily dose, convert to long-acting formulation (fentanyl patch, 72hr duration + oxycodone) PLUS short-acting opioids for breakthrough pain

glucocorticoid injections can be used as adjunctive therapy if there is incomplete improvement on opioid therapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
52
Q

thalamic stroke

A

ischemia of sensory thalamic nuclei - contralateral loss of sensation and tingling
- delayed episodic, severe pain with ongoing paresthesias (Dejerine-Roussy syndrome)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
53
Q

parotid neoplasm

A

two lobes of the parotid gland - separated by facial nerve = motor to face

54
Q

brachial plexus

A

axillary nerve injury - fracture of humerus neck, anterior dislocation of humeral head

  • note anterior dislocation usu due to externally rotated abducted arm
  • paralysis of deltoid and teres minor, sensory loss over lateral upper arm –> weak shoulder abduction
  • deltoid weakness appreciated at extreme extension

Klumpke palsy - sudden upward traction of arm

musculocutaneous nerve - biceps, brachialis, coracobrachialis

  • elbow flexion and forearm supination
  • sensation of radial aspect of forearm

radial nerve - injured in humeral mid-shaft fractures and improperly fitted crutches

  • radial nerve - responsible for wrist extension and arm extension
  • triceps innervation comes off proximal to humeral spiral groove

ulnar nerve entrapment - most commonly at elbow (wrist less common, forearm can occur in diabetics)
- claw hand - weakness of the hypothenar and interosseus muscles

Parsonage-Turner syndrome - acute idiopathic brachial plexopathy

  • acute, severe shoulder pain….
  • sometimes - hx of preceding viral infection or vaccination
55
Q

biceps tendon rupture

A

during forceful FLEXIOn of arm

- audible pop, visible bulge (where biceps muscle retracts into upper arm)

56
Q

Marfanoid body habitus

A

think Marfans or homocystinuria

common features - pectus, tall stature, arachnodactylyl, joint hyperlaxity, skin hyperelasticity, scoliosis

Marfans - AD

  • normal intellect
  • aortic root dilation
  • upward lens dislocation

Homocystinuria - AR

  • ID
  • fair complexion
  • thrombosis (CVA)
  • megaloblastic anemia
  • downward lens dislocation
  • treat with vitamin B6 and B12 to lower homocysteine levels, PLUS give antiplts or anticoag

v. s. Ehlers-Danlos - collagen disorder…. no other similarities to Marfans

v. s. PKU (AR) - fair skin, ID, eczema, must body odor
- newborn screening - via tanden mass spec (to look for presence of metabolic products of phe)
- get quantitative amino acid analysis later in life - will see elevated phe levels

57
Q

glycogen/lysosomal storage disorders

A

Fabry - a-galactosidase deficiency
- angiokeratomas, peripheral neuropathy, asymptomatic corneal dystrophy, renal and HF, thromboembolic events

Krabbe - AR, galactocerebrosidase deficiency
- ID, blindess, deafness, paralysis, neuropathy, seizures

Tay-Sachs - AR, b-hexosaminidase A
- ID, weakness, seizures, cherry-red macula

58
Q

SIDS

A

limit second hand smoke, use a pacifier, room-sharing (w/o bed sharing)

SUPINE position - to reduce risk

59
Q

HIV

A

primary CNS lymphoma - EBV DNA in CSF

  • single ring-enhancing mass
  • v.s. toxo - multiple ring-enhancing masses (side note - pos toxo serology is common in normal people)
  • v.s. nocardia - brain abscess with ring-enhancing lesions (CD4 < 100)

AIDS dementia - cortical and subcortical atrophy and secondary ventricular enlargment

cryptococcal meningitis - CSF with elevated opening pressure, low leukocytes with monos, slightly elevated proteins, low glucose
- organisms by India ink

60
Q

chemo-induced peripheral neuropathy

A

vincristine, platinum (cisplatin), taxanes (paclitaxel)

stocking-glove pattern, loss of reflexes, loss of pain and temp sensation
- can have motor neuropathy -bilateral foot drop
(side note - all this except for the the motor neuropathy occurs in diabetic neuropathy)

61
Q

brain arteries

A

ACA occlusion - contralateral LE motor and sensory deficits
+ UMN signs
- abulia - lack of will or initiative
- dyspraxia, emotional disturbances, urinary incontience

lacunar infarct (post limb of internal capsule) - unilateral motor impairment

  • OFTEN with symptoms improving spontaneously
  • other features - pure sensory stroke, ataxic hemiparesis, dysarthria-clumsy hand
  • small penetrating artery occlusion due to hypertensive arteriolar sclerosis (small-vessel lipohyalinosis)
  • areas affects - BG, subcortical white matter, pons
  • pons = dysarthria-clumsy hand syndrome
  • because they are small, they wont be seen on CT immediately after stroke
  • risk factors - HTN, DM, advanced age, high LDL, smoking
  • NO cortical signs (aphasia, agnosia, neglect, apraxia, hemianopia)

MCA - contralateral motor

  • conjugate eye deviation TOWARDS infarct
  • homoymous hemianopia, aphasia (dominant hemisphere L) - hemineglect (non-dominant hemisphere parietal R)

PCA - homonymous hemianopia (with macular sparing), alexia without agraphia, visual hallucinations, sensory symptoms (thalamus), 3rd nerve palsy, contralateral motor deficits

vertebrobasilar system lesion - contralateral hemiplegia, ipsilateral CN involvement
- may have ataxia

62
Q

locked in syndrome

A

ventral brainstem injury

63
Q

carotid artery disease

-dissection

A

amaurosis fugax - “curtain falling over eye,” transient

  • atherosclerotic emboli from carotid artery
  • in your differential - cardioembolic disease, giant cell, retinal vein occlusion, retinal vasospasm, papilledema

traumatic carotid injuries

  • mechanism - penetrating trauma, fall with object in mouth (toothbrush, pencil), neck manipulation (yoga, sports)
  • can be due to fibromuscular dysplasia
    - internal carotid is posterior to the tonsillar pillars
  • presents with hemiplegia, aphasia, neck pain, thunderclap headache, Horners
  • CT or MRA

for carotid artery atherosclerosis

  • workup for TIA - EKG, carotid US, echo to find etiology
  • initial interventions for carotid artery disease - ASA, statin, BP control, lifestyle changes
  • stenosis >60% - stent
  • for symptomatic pts with high-grade stenosis (70-99%) - CEA
    - pts with disabling neurologic deficits, 100% carotid occlusion, or life expectancy of <5yrs are unlikely to benefit
64
Q

spinal epidural abscess

A

S aureus, hematologic spread

classic triad = fever, focal/severe back pain, neuro findings (starts with nerve root pain, shooting and electric)
- suprapubic mass - distended bladder due to urinary RT

ddx - elevated ESR, blood and aspirate cultures, MRI spine

treat - vanc + ceftriaxone (broad spectrum)
- aspiration and surgical decompression

65
Q

Bells palsy

A

inflammation and edema of facial nerve

often due to herpes simplex activation

peripheral (lesion below pons) - inability to raise eyebrow or close eye

forehead sparing (ability to wrinkle forehead) - suggestive of an intracranial lesion, warrants brain imaging

for most pts - partial or complete recovery occurs within 6 mo

66
Q

eye nerves

A

oculomotor nerve palsy - mydriasis, ptosis, down and out eye

  • uncal herniation, p.comm aneurysm
  • nerve ischemia (DM) - down-and-out gaze with preserved pupillary response - because of which fibers control what and inner fibers are furthest from the blood supply (so are more susceptible to ischemia)

nerve compression - mydriasis (PS fibers are on the outside of the nerve)

67
Q

shaken baby syndrome

A

shearing of subdural veins

68
Q

brain death

A

3 cardinal findings

  • unresponsiveness
  • absence of brainstem reflexes
  • apnea

absent cortical and brain stem functions

  • note brain stem controls- CNs, vagus nerve (heart), respiratory center (no spontaneous breathing at high PCO2)
  • SC may still be functioning = DTRs may be present
  • brainstem reflexes - fixed pupils, no corneal reflex, absent oculovestibular reflexes, no gag, no response to supraorbital pressure

isoelectric EEG can be used as a confirmatory test - not necessary though

69
Q

uveitis

A

anterior uveitis - pain and redness, blurry vision, photophobia

posterior uveitis - floaters, reduced visual acuity

70
Q

myopathy

A

glucocorticoid-induced - occurs weeks to mo after starting

  • weakness, without pain
  • LE muscles are more involved
  • note glucocorticoids also cause bone loss and hyperglycemia

polymyalgia rheumatica - pain and stiffness in shoulder and pelvic girdle

  • can be seen in 50% of pts with temporal arteritis
  • responds to glucocortoids (low dose)
  • elevated CK

inflammatory myopathies - pain, proximal weakness

  • skin rash and inflammatory arthritis
  • elevated ESR and CK

statin-induced - elevated CK

hypothyroid myopathy - proximal muscles, delayed DTRs, myoedema
- elevated CK

71
Q

botulism

A

improperly canned foods, cured fish

inhibits presynaptic Ach release

onset 36 hrs after ingestion (GI upset) –> bilateral cranial neuropathies ( blurred vision, diplopia, facial weakness, dysarthria, dysphagia)

  • symmetric descending weakness
  • diaphragmatic weakness - may need mechanical ventilation

EMG - decreased compound muscle APs, repetitive stimulation increases amplitude

serum analysis for toxin

treat with equine serum antitoxin

72
Q

atropine and pralidoxime

A

treat cholinergic tox (ex organophosphate poisoning)

  • atropine blocks peripheral effects of Ach at muscarinic receptors
  • pralidoxime - reactivates AchE
73
Q

herpes encephalitis

A

focal neuro findings - AMS, CN deficits, fever, behavioral changes
- NO rash

CSF - lymphocytic pleocytosis, erythrocytosis (due to hemorrhagic destruction of temporal lobes), elevated protein levels
- PCR analysis of HSV DNA in CSF (high sensitivity and specificity)

brain imaging - temporal lobe lesions (MRI > CT)

treat with IV acyclovir

74
Q

brain tumors/cancer

A

progressive morning headache

supratentorial tumors - can cause seizures

supra and infratentorial tumors can cause symptoms of increased ICP

meningioma - calcified, benign –> complete resection
- commonly found in middle-aged women

medulloblastoma - peds tumor

  • nocturnal or morning headaches
  • cerebellar dysfunction

low grade astrocytoma

  • most common brain tumor in children
  • dont undergo malignant transformation
  • px due to mass effect and compression of surrounding structures = seizures

glioblastoma - butterfly, central necrosis, serpiginous contrast enhancement

CPA angle

  • acoustic neuroma, meningioma
  • headache, hearing loss, vertigo, tinnitus, balance problems

posterior fossa tumor - can injure glossopharyngeal nerve

  • loss of gag reflex, taste on post 1/3, loss of pharyngeal sensation
  • dysfunction of carotid sinus –> increased risk of syncope

mets are more common in adults - lung > breast > other > melanoma > colon

  • mets that will be solitary - breast, colon, RCC
  • mets that are multiple - lung cancer, malignant melanoma
  • brain mets are at gray-white junction
  • sxs of less than 2 mo
  • give glucocorticoids to reduce swelling + for palliative care - leads to a survival time of 1-2 mo
    - if prognosis is favorable and there is a single met - surgical resection followed by radiosurgery/radiation
  • note - primary cns tumors are more common in KIDS
75
Q

meningitis

A

bacterial

  • fever, increased ICP, meningeal irritation
  • complications in kids - hearing loss, ID, CP, epilepsy (so developmental f/u and audiologic testing is required)

Listeria - ampicillin

Tb meningitis - subacute presentation
- CSF glucose is VERY low - less than 10

herpes meningoencephalitis
- can have high RBC and protein levels - reflects temporal lobe hemorrhage

76
Q

head trauma in kids 2-18

A

severe = GCS < 13, focal neuro deficits, skull fracture, seizure, AMS, prolonged LOC –> head CT wo contrast

mild = GCS 13-15 w/ vomiting, headache, brief LOC, high-risk mechanism, severe mechanism (car crash with ejection, passenger fatality, rollover, auto-ped, fall height >5ft, high impact head hit) —> observe 4-6hrs or head CT wo contrast

  • concussion is considered mild TBI
  • why do you get neuroimaging with mild? - bc sxs often overlap with severe TBI

minor head trauma (GCS 15) - no head CT

77
Q

brain abscess

A

viridans strep, s aureus, gram negative orgs

path - adjacent infection (sinusitis, dental infection), hematogenous (will see multiple abscesses at gray-white junction)
- bacteremia is also an increased risk in cyanotic HD - where the lungs (filter) are bypassed

px - headache (resistant to analgesia), fever (50%), focal neuro deficits, seizure

  • initially - imaging with show cerebritis
  • in 1-2 wks - will show ring-enhancing lesion with central necrosis

treat - empiric prolonged IV abx (metro, cef, vanc) + aspiration (surgical drainage)

78
Q

speech

A

brocas - frontal lobe

  • Boca - damage means they have expressive aphasia
  • right hemiparesis
  • can have gaze deviation to the side of the lesion
  • awareness of deficit

wernickes - temporal lobe

  • receptive aphasia
  • right superior visual defect
  • no awareness of deficit

arcuate fasciculus - through the frontal and parietal lobes
- conduction aphasia - fluent with phonemic errors

repetition impaired in brocas and wernickes aphasia

nondominant frontal/temporal lobe lesions - affect emotion

  • frontal lobe - affects the way person conveys emotion through speech
  • temporal lobe - inability to comprehend emotion gestures
79
Q

dissection

A

carotid artery dissection –> ipsilateral (partial) Horners

vertebral artery dissection (inferior cerebellar artery occlusion) - lateral medullary (Wallenberg) syndrome

  • loss of pain/temp over ipsilateral face and contralateral body
  • vertigo, ipsilateral ataxia
  • Horner syndrome
  • due to damage of vestibular nuclei and inferior cerebellar peduncle
80
Q

berry aneurysms

A

affect acomm and pcomm

acomm - compress optic chiasm –> bitemporal hemianopia

pcomm - 3rd nerve palsy (down and out eye)

81
Q

neuro for babies

A

lower the birth weight - the greater the risk for intraventricular hemorrhage

  • vascular perfusion injuries (hypoxia, hypotension, reperfusion of damaged vessels, increased venous pressure, abrupt changes in cerebral flow) - can also lead to IVH
  • have to do transfontanel US for all newborns with predisposing risk factors
  • grades 1-4 - grades 3-4 are associated with long-term sequelae
82
Q

leg nerves

A

femoral - anterior compartment of thigh

  • flexion at hip, extension at knee
  • sensation to anterior thigh and medial leg

obturator nerve - medial thigh

  • adduction
  • sensation of medial thigh

tibial nerve - posterior compartment of thigh, post leg, and plantars
- sensation to leg

common peroneal (aka fibular)

  • susceptible to compressive injuries at fibular head (leg crossing, bedrest, cast) –> transient symptoms
  • worse in thin inds or people who have lost a sig amount of weight
  • superficial and deep peroneal - anterior and lateral leg
  • dorsum of foot
83
Q

cavernous sinus

A

pituitary
IC
nerves - 3-6

cavernous sinus communicates across midline - so unilateral sxs become biateral

facial/ophthalmic venous system - no valves

  • SO adjacent infections can spread to the cavernous sinus –> infectious cavernous sinus thrombosis
  • get MRI
  • treat with broad spectrum abx (+ prevention, reversal of cerebral herniation)
84
Q

amitriptyline

A

inhibits reuptake of NE and serotonin - but has MANY other receptor interactions

  • anticholinergic sxs
  • histamine receptors - lethargic
  • a1 receptors - orthostatic hypotension
85
Q

ataxia

A

sensory ataxia - pos Romberg
- peripheral roots, dorsal roots, posterior column

cerebellar ataxia - use tandem gait testing

  • staggering, wide-based gait, truncal ataxia
  • dysdiadochokinesia, dysmetria or intention tremor, Romberg (romberg tells about vestibular function), nystagmus
  • muscle hypotonia - pendular knee reflex
  • can occur in alcoholics (alcoholic cerebellar degeneration)

gait apraxia (frontal gait) - start and turn (magnetic)

  • due to damage to cortico-cortical white matter fibers of frontal lobe
  • dementia, incontinence, frontal lobe signs
  • causes - frontal lobes degeneration, NPH

Parkinsonian - short, shuffling

steppage - due to motor neuropathy

  • foot drop (because you cant dorsiflex, L5 radiculopathy or common peroneal nerve neuropathy), excessive hip and knee flexion when walking
  • slapping quality
  • falls
  • distal sensory loss and weakness

vestibular - acute labyrinthitis, meniere disease
- staggering gait + vertigo and nystagmus

pyramidal tract or CST - spastic ataxia

86
Q

neuroleptic malignant syndrome

A

neuroleptic = dopamine antagonist

fever > 40/104, confusion, muscle rigidity, autonomic instability

1) stop antipsychotics, restart dopamine
2) supportive care
3) dantrolene or bromocriptine

v. s. lithium tox - tremors, ataxia, AMS, N&V, hypotension

v.s. serotonin syndrome - AMS, autonomic instability, and NM excitability (tremor, hyperreflexia, myoclonus)

87
Q

neurocysticercosis

A

taenia solium (pig)

new-onset seizure

cysts at various stages of development - nonenhancing/hypodense lesions, calcified granulomas

88
Q

pontine hemorrhage

A

pinpoint pupils - descending sympathetic fibers have been destroyed

89
Q

cerebral venous thrombosis

A

hypercoagulable conditions - OCPs, malignancy

headache, confusion, seizures, focal neuro deficits

confirm with MRI (CT will show nothing)

90
Q

MD

A

Duchenne and Becker - XR
….
- Duchenne - comorbidities are scioliosis, cardiomyopathy
- wheelchair-dependent by adolescence, death by 20s-30s due to respiratory or heart failure
- can try corticosteroid treatment
- Becker - cardiomyopathy
- death by 40-50s due to heart failure

myotonic dystrophy

  • AD - CTG repeat
  • onset - 12-30
  • facial weakness, hand grip, myotonia (delayed muscle relaxation, ex pt wont be able to release hand after handshake), dysphagia
  • comorbidities - arrhythmias, cataracts, balding, testicular atrophy/infertility
  • death from respiratory/heart failure
91
Q

dopamine pathways

A

mesolimbic - antipsychotic efficacy

nigrostriatal - coordination of movement
- EPS, acute dystonia, akathisia, parkinsonism

tuberoinfundibular - hyperprolactinemia
- esp risperidone (high affinity for D2 receptors)

92
Q

hyperglycemic nonketotic state

A

AMS and/or neuro deficits

sxs at BG > 600 mg/dL (usu >1000 mg/dL)

93
Q

West Nile Virus

A

fever, headache, confusion

neuroinvasive WNV –> myelitis –> asymmetric flaccid weakness in limbs

94
Q

clotting disorders

A

AT3 deficiency - increased risk of spont venous thromboembolism
- but usu in femoral and mesenteric veins (cerebral thromboses are less common)

homocystinuria - lens dislocation, ID, marfanoid feature, increased risk of arterial and venous thrombi

95
Q

giant cell arteritis

A

consider in pts >50 with new onset headaches (temples)

fever, weight loss, vision changes, jaw claudication (fatigue, pain with chewing)

96
Q

cataract

A

loss of transparency of lens

  • sxs - blurred vision, glare, halos around lights
  • as cataract progresses - retinal detail may be lost

risk factors - age, DM, smoking, chronic sunlight exposure, glucocorticoid use

v. s. macular degeneration - which affects central vision, dry (slow, progressive, bilateral) and exudative (unilateral, agressive)

97
Q

central retinal vein occlusion

A

painless loss of vision - due to thrombosis of retinal vein

blood and thunder appearance = venous dilation, diffuse hemorrhage, cotton wool spots, disk swelling

treatment

  • if there is no significant macular edema - close observation
  • macular edema - VEGF inhibitor injection

note - central retinal artery occlusion is much more acute

  • painless monocular vision loss
  • embolic source
  • fundoscopic exam will show retinal whitening
  • tx - ocular massage, anterior chamber paracentesis, revascularization and asa, statin, or warfarin are initiate to prevent future attacks
98
Q

delirium

A

fluctuating mental status, sundowning

aka toxic-metabolic encephalopahty - inattention, confusion, asterixis
- asterixis is not always associated with alcoholism

many causes

  • drugs - benzos, antihistamines, muscle relaxers, sedatives
  • infections
  • electrolyte disturbances
  • metabolic derangements
  • systemic illness - CHF, hepatic failure, malignancy
  • CNS disturbance
  • risk factors - advanced age, dementia

CMP, CXR, CBC, UA, review med list

management - AVOID polypharmacy and physical restraints

  • maintain normal sleep-wake cycle - so reduce nighttime noises and disturbances
  • frequent reorientation
  • treat underlying cause
  • initial treatment for agitation - low dose haloperidol (can also use quetiapine, risperidone)
    - -> note prolonged use can increased mortality in elderly
99
Q

hypokalemia

A

weakness, fatigue, muscle cramps

severe hypokalemia (< 2.5) - flaccid paralysis, hyporeflexia, tetany, rhabdomyolysis, arrhythmias

causes - diuretic, diarrhea, vomiting, anorexia, hyperaldosteronism

EKG - flat T waves, U waves, ST depression, PVCs, etc.

hypokalemic periodic paralysis
- AD - due to defects in ion channels
- attacks of flaccid limb weakness (+ decreased DTRs)
- starts in early adulthood/adolescence
- occurs after awakening - after eating a high carb meal, alcohol, cold weather, exercise
- lasts hrs -days - can resolve completely, can leave residual weakness

100
Q

lobes

A

dominant temporal lobe

  • medial temporal lobe - memory
  • lateral temporal lobe –> semantic issue - lost sense of what features make one animal distinct from other animals
  • note alzheimers - progresses from medial to lateral temporal lobe

parietal lobe
- astereognosis - inability to identify an object by touch of the hands

non-dominant parietal lobe - visuospatial function (drawing intersecting pentagons)

101
Q

CTS

A

sxs worse at NIGHT

compression at forearm if pt also has thenar eminence numbness and weakness of thumb flexion
- both nerves branch before the carpal tunnel

inability to make OK sign

1) wrist splint in neutral position, steroid injection, possible task modification
2) nerve conduction study
3) surg consult

102
Q

small fiber neuropathy

A

C and A delta fibers are affected - loss of pain and temp

reflexes, proprioception, vibration sense intact

103
Q

REM sleep behavior disorder

A

loss of motor atonia normally present during REM sleep = pts act out their dreams

associated with subsequent onset of neurodegenerative disorders and synucleinopathies (Parkinsons)

104
Q

acute low back pain

A

uncomplicated acute back pain - usu due to MSK injury or degeneration
- give NSAIDs

red flags - trauma at onset, prior malignancy, weight loss, fever, IVDA

radicular pain
- can try epidural steroid injections or TCADs down the line

105
Q

diabetes

A

diabetic neuropathy
- painful - give lyrica

pupil-sparing third nerve palsy - down and out pupil
- due to microvascular infarct of central fibers, peripheral fibers are spared so preserved pupillary reflex (v.s. with herniation, where peripheral PS fibers are compressed)

106
Q

paroxysmal focal neuro sxs

A

TIAs - abrupt onset

seizures - 2-3min

migraine aura - 15-30 min, visual or tingling aura

107
Q

neuromyelitis optica

A

can look like optic neuritis/MS, but is NOT

anti-aquaporin-4 antibodies

aggressive - does not respond to treatments for MS
- requires more aggressive immunosuppressive therapy

108
Q

disc herniation

A

ex - C5-C6 disc herniates –> C6 will be compressed

shooting pain

C5
C6 - index finger, thumb
C7
C8, T1 - ring, little finger

109
Q

chronic inflammatory demyelinating neuropathy

A

weakness, absent DTRs, sensory deficits = points to peripheral NS problem

can be due to arsenic - but this would show cognitive impairment overtime

can be due to prolonged diabetes

110
Q

anti-emetics

A

frequently have dopamine blocking properties

- ondansetron does not

111
Q

transient global amnesia

A

isolated short-term memory impairment - resolves in 24hrs

can have MRI abnormalities - bilateral hyperintense hippocampi (on T2 flare)

association with migraines

reassurance

112
Q

hearing

A

Rinne - conductive hearing
Weber - sensorineural

conductive hearing loss - limits sound from reaching inner ear

  • otitis externa or media
  • cholesteatoma - chronic, progressive, bulging or dulling of tympanic membrane
  • trauma
  • cerumen
  • ruptured TM - would be visible
  • altitude/ear pressure changes
  • otosclerosis - sclerosis of ossicles, normal otoscopic exam

sensorineural - disorder of inner ear, cochlea, or auditory nerve

  • presbycusis - “difficulty tolerating loud sounds that others can hear”, subjective tinnitus
  • Menieres - vertigo, tinnitus, hearing loss
  • barotrauma
  • schwannoma - unilateral tinnitus, hearing loss, vertigo
  • cerebrovascular ischemia
113
Q

pineal gland

A

tumor –> parinaud syndrome

- loss of vertical gaze, loss of pupillary light reflex, lid retraction, nystagmus

114
Q

transverse myelitis

A

LE weakness and numbness

- associated with increased reflexes due to CST involvement

115
Q

trigeminal neuralgia

A

neuropathic pain along V2 and V3

pathophys - related to demyelination along trigeminal nerve root (as it enters pons)

  • due to localized compression (vascular structure)
  • usually unilateral UNLESS it is due to MS - in which case it would present bilaterally

treat with carbamazepine, oxcarbazepine

  • side effect of carbamazepine - leukopenia, aplastic anemia (CBC in monitoring)
  • surgery

burning mouth syndrome

116
Q

trachoma

A

due to C. trach A-B –> leading cause of blindness worldwide

conjunctival injection, tarsal inflammation, pale follicles (on tarsal conjunctiva, pull eyelid up)
- can often have concomitant nasopharyngeal infeciton

chronic infection –> scarring + inversion of eyelashes –> lashes rub on eye, cause ulcerations –> blindness

oral azithromycin
- for trichiasis (ingrown eyelashes), need eyelid surgery to preserve vision

117
Q

strabismus

A

usually due to brainstem lesions

findings - strabismus, eye deviation after 4 mo of age (note ocular instability of infancy before age 4mo), asym corneal light reflex or red reflex, deviation on cover test, head tilt (torticollis)

usually due to nasal deviation (esotropia)

treat with
1 penalization therapy - cycloplegic drops to blur normal eye
1 patch NL eye
- prescription eye glases
- surgery

complications - amblyopia, diplopia

118
Q

foreign body in eye

A

fluorescein exam –> US or CT

- NO MRI

119
Q

eye ulcers

A

herpes zoster ophthalmicus

  • VZV
  • ophthalmic branch (TG) - forehead, eye (conjunctivitis, corneal ulcers)
  • treatment w/i 72hrs after eruption with high dose acyclovir reduces complication risk

herpes simplex keratitis - pain, photophobia, decreased vision
- dendritic ulcer, vesiculoulcerative lesions

bacterial keratitis - contact lens wearers, corneal trauma

  • hazy cornea with central ulcer, adjacent stromal abscess
  • can have hypopyon (pus layers in cornea)
120
Q

retinoblastoma

A

leukocoria (white reflex)
- strabismus, decreased vision, ocular inflammation, eye pain, glaucoma, orbital cellulitis

mass with calcifications on CT or US

highly malignant tumor - death from liver and brain mets

121
Q

pronator drift

A

indicates UMN or pyramidal/corticospinal tract disease

why - UMN lesions cause more weakness in the supinator muscles compared to the pronator muscles

122
Q

alcoholic cerebellar degeneration

A

10+ years of heavy alcohol use

degeneration of Purkinje cells (cerebellar vermis)

px - wide-based gait, incoordination in legs, postural instability
- impaired tandem walking/heel to skin but preserved finger-nose testing

dx - CT/MRI will show cerebellar atrophy

tx - alcohol cessation, nutritional supplements, ambulatory assistance
- this prevents progression but does not reversion

v. s. a diabetic small vessel injury - would present as a polyneuropathy of small fibers (pain and temp) and large fibers (vibration and proprioception)
- gait is preserved

123
Q

Edinger-Westphal nucleus

A

damage leads to fixed dilated pupil - nonreactive to light or accommodation

Edinger-Westphal nucleus provides PS outflow to eye

124
Q

trochlear nerve palsy

A

vertical diplopia - compensatory mechanism is tucking chin and tilting head away from affected eye

125
Q

brainstem lesion

A

cranial nerve dysfunction ipsilateral to lesion, contralateral motor/sensory weakness

126
Q

restless leg syndrome

A

secondary causes include - Fe anemia, uremia, DM, MS, Parkinsons, pregnancy, drugs (antidepressants, metoclopramide)

tx

  • for mild/intermittent - Fe supplement if needed, supportive measures (leg massage, heating pads, exercise), avoidance of aggravating factors (sleep deprivation, meds
  • severe - pramipexole and ropinirole (dopamine agonists), gabapentin is second line
127
Q

pain control

A

in recovering opioid addicts - still use IV morphine

  • FOLLOWING discussion of risks/benefits
  • methadone (slow onset) is used for chronic pain - rather than acute pain

IV ketorolac (NSAID) - used for short-term treatment of severe pain

128
Q

spinal stenosis

A

most commonly caused by degenerative joint disease - disc herniation and osteophytes compress cord
- other factors include - hypertrophy of ligamentum flavum, bulging of intervertebral dsics, spondylolisthesis (displacement of vertebral body relative to another)

flexion opens up canal
- pain worse with walking = neurogenic claudication

dx - MRI

tx - PT and exercise

129
Q

bone scan

A

useful to identify areas of high bone turnovers - metastatic disease, suspected fractures, osteomyelitis

130
Q

tetanus

A

trimus, painful spasms
- other sxs - sweating, dysphagia, labile BP, tachy

toxin blocks release of inhibitory neurotransmitters - glycine and GABA

tx - debride wound, abs, human tetanus Ig AND tetanus toxoid

botulism - impaired Ach release

131
Q

cerebral vasospasm

A

cocaine/amphetamine - causes hemorrhagic or ischemic stroke

- will show up on noncon CT