Neuro Flashcards

1
Q

Proportion of the strokes by type

A

80% ischaemic
15% intra-parenchymal bleeds
5% SAH

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2
Q

Causes of vessel blockage

A

Atherothromboembolism (50%)
Vessel disease (25%)
Cardiac source of embolism (20%)
Rare causes (5%)

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3
Q

SAH - on CT where is the blood

A

fill the cisterns

may be intra-parenchymal

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4
Q

stroke rule of thirds

A

third die
third left dependant
third will survive

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5
Q

Differentials to consider for stroke

A
Epilepsy
Tumour
Abscess
Hypoglycaemia
Encephalitis
Other sepsis
Syncope, etc.
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6
Q

What information is required for clinical management?

A

Is the lesion vascular or non-vascular?
If vascular, is it an infarct or a haemorrhage?

Is there an underlying structural cause?

How extensive is the infarct?
If more than a third of the middle cerebral artery (MCA) territory is affected at presentation, then there is a high risk of haemorrhage with thrombolysis
Are there any features to suggest large vessel occlusion?
Questions regarding ischaemic penumbra and salvageable tissue are assessed by CT perfusion, which is not routinely performed

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7
Q

if something is dense (white) and has mass effect on CT it is

A

Haemorrhage

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8
Q

underlying lesion like a tumour or vascular malformation, then there may be some features to suggest that

A

underlying lesion like a tumour or vascular malformation, then there may be some features to suggest that

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9
Q

causes of haemorrhage

A

trauma, haemorrhagic transformation of an arterial or venous infarct, or to amyloid angiopathy

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10
Q

Low density after stroke (haemorrhage)

A

old

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11
Q

High density after stroke

A

new

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12
Q

Rate of change in density varies with size of lesion

A

smaller bleeds get removed quicker.
small will be hypodense at 7 days
large may take 12 weeks.

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13
Q

Slit like appearance of CSF fluid raises consideration for

A

ex vacuo from an old haemorrhage.
infarct would be more rounded

slits are more for the basal ganglia or centrum semiovale

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14
Q

Why is MR so good at measuring wether haemorrhage has taken place?

A

due to haemosiderin deposition which paramagnetic

However, it is not good for acute haemorrhage

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15
Q

Cortical infarcts

A

subtle as a small focal defect in the normal slightly hyperintense cortical ribbon

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16
Q

Cortical/subcortical

A

Infarcts involving a distal branch vessel cause a wedge shaped area of low attenuation involving the cortex and subcortical white matter (Fig 2)

17
Q

Perforator

A

Infarcts of a small volume of tissue surrounding an end perforator vessel, e.g. lenticulostriate arteries (Fig 3)

18
Q

Large vessel occlusion

A

Occluding the MCA or even internal carotid artery (ICA) at the skull base causes a very large infarct involving both deep grey matter structures and a large wedge of cortex and subcortical white matter

19
Q

When does mass afffect peak in ischaemic stroke

A

3 days

20
Q

Hyperacture (0 - 6 hours) may show what?

A

may be normal (remember the thalamic infarction that didn’t show initially)

21
Q

what is fogging

A

1 - 3 weeks - the infarct can become isodense with normal brain and lose mass effect - so it can be easily overlooked.

22
Q

lenticulostirate territory infarction - present as what

A

definition is lost making it the same as the surrounding white matter

23
Q

why does a clot show up as hyperdense vessel

A

plasma is taken out and higher concernation of haem

24
Q

eyes can turn to which way?

A

they turn to look at the side affected

25
Q

VST develop ishaemia from…

A

haemorrahge

26
Q

When is MR most useful and what sequences should be used?

A

Haemorrhage in patients presenting late after stroke
Definite ischaemic stroke in patients with mild stroke and specific underlying causes, e.g. arterial dissection, genetic syndromes and venous thrombosis

T1W sagittal sequence
T2W sagittal sequence
Fluid attenuated inversion recovery (FLAIR)
Gradient echo (also known as T2*)
Diffusion-weighted axial images
27
Q

most sensitive MR sequence of early ischaemic change?

A

DWI