Neural Crest And Eye Development

Question 1

Where do Neural crest cells originate from?

Answer 1

LATERAL Margins of the Neural PLATE

• Epithelial in origin
• Then Transform into MESYNCHYMAL cells for migratory purposes

Question 2

What inducts Neural crest tissue from NON-Neural Ectoderm?

Answer 2

BMP’s and Wnts

Question 3

What inducts Neural crest tissue from Mesoderm?

Answer 3

FGF-8

Question 4

What are responsible for Neural crest to form Tight Jxns in Neural Tube?

Answer 4

Cadherins and CAMs

Question 5

What are important in allowing cells to break free?

Answer 5

• Snail-1
• Snail-2
• Foxd3

Question 6

Migrating paths in neural cell migration. Order them in terms of Emigrating cells

Answer 6

• 1. Ventral-Sympathoadrenal
     
     2. Ventro-Lateral
     3. Dorso-Lateral

Question 7

Ligand/Receptor Pair guidance molecules

Answer 7

1. Robo/Slit
2. Neuropilin/Semaphorin
3. Ephrin/Eph

Question 8

What Migratory pathway is most Preferable?

Answer 8

Basal Lamina

Question 9

EX matrix components of Migratory pathway substrates

Answer 9

• Fibronectin
• Laminin
• Type 4 Collagen

Question 10

Early vs Later vs Late Migratory Neural Crest cells

Answer 10

Early
- Most pot. for DIFFERENTIATION

Later
- Can only diff into cell of DORSAL locations

Late
- Can only for Melanoblast

Question 11

Neural Crest Cell Division

Answer 11

1. Trunk
2. Cranial
3. Circum-Pharyngeal
4. Cardiac
5. Vagal

Question 12

The Trunk Neural crest extends from what Somite?

Answer 12

6

• Caudally

Question 13

Three migration Pathways of the Trunk Neural crest

Answer 13

1. Sympatho-Adrenal
2. Ventro-Lateral
3. Dorso-Lateral