Nervous System Development I Pt II Flashcards
Characteristics of the Isthmic Organizer
- Located b/w Mesencephalon and the Metencephalon
- It is a SIGNALING Center
- Organizes and Polarizes Dorsal midbrain Midbrain and Cerebellum
What is the Principal Signaling molecule of the Isthmic Organizer?
FGF-8
What signaling molecules induce expression of En-1/2 and Pax-2/5?
- FGF-8
2. Wnt-1
Dorso-Ventral patterning of midbrain is primarily due to what?
SHH
SHH restricts the expression of what in Dorso-Ventral patterning?
Pax-7
What is the role of Pax-7?
Related to the formation of the ALAR plate
What is the role of Pax-6?
- Expressed in Alar plate
- “Master Gene” of EYE formation
- Inhibits En-1 and Vice-Versa
- Results in the formation of the diencephalon and mesencephalon BORDER
The forebrain is segmented into what?
3 Pro-Someres
9P1-3)
Characteristics of P1-P3
Defines the Diencephalon
Characteristics of P2-P3
Define the Dorsal/Ventral Thalamus
The Alar plate develops into what?
- Cerebral Cortex
- Basal Nuclei
- Optic Vesicles
Motor Axon Outgrowth
- Axons grow out from the motor neuroblast
located in the basal plate of the spina cord
What maintains the separation b/w CNS and PNS
Boundary CAPS
- Created by Neural Crest Cells
Formation of a sensory neuron
- Cell bodies of sensory neurons are derived from Neural Crest Cells
(They form sensory spinal ganglia) - Boundary caps maintain the separation
Cells bodies of sensory neurons form what?
Sensory Spinal Ganglia
Cues involved in Axon guidance
- Caudal Half of somite
- Fibronectin
- Laminin
- Integrins
- Cadherins
FLICC
Role and Relationship of Pioneering Axon
The first axons to grow in a particular region
- Main fxn is laying down the initial growing path that subsequent growing axons
- NO anatomical difference b/w Pioneer and Follower axons
What happens when a Motor Axon meets a muscle fiber?
Formation of NMJ
- Cessation of Outgrowth of Axon
- Preparation by Neuron for release of NT molecules (ACh)
- Muscle fiber preparation for signal transduction
What determines whether migrating neural crest cells differentiate into Autonomic neurons or other neural crest derivatives?
BMPs
The sympathetic Pre-Ganglionic MN arise from what?
Intermediate Lateral Horns of Gray matter
T/F: Sympathetic POST-Ganglionic MN are myelinated.
False
- They are NOT Myelinated
The Parasympathetic Pre-Ganglionic MN are associated with what kinds of nerves?
Cranial Nerves
- 3, 7, 9, and 10
Sympathetic cells are typically _____ and Parasympathetic cells are typically _____.
- Adrenergic
2. Cholinergic
