Networks Flashcards
What is a downside of global networks.
Overall view but not detailed enough to capture complex topological characteristics of large networks.
What are the four global properties?
Degree distribution
Clustering coefficient
Betweenness centrality
Shortest path length.
What is the consequence of a network with few connection?
More robust as more connections make any perturbation have an effect.
Outline the yeast 2 hybrid system .
Bait fused to reporter
Prey fused to TF
How does a local network differ?
More detailed
More restraints - reduces degrees of freedom in which networks being compared can vary.
Define a random network.
Graph of n nodes where edges between added uniformly and with SAME probability.
What can network motifs be used for?
Comparing real and random networks
Random networks have no selection acting
Where do enzymes feature in metabolic networks and what do connections represent?
Edges
Transformations.
What is the main resource for metabolic networks?
KEGG
Gives info on genes, proteins, reactions, pathways.
For a Eu and prokaryotes.
Compares which genes are up or down regulated.
What is significant regarding gene regulatory networks?
Regulate each other collectively (use genome wide profiling to observe)
Control response of cell to environment by regulating OTHER GENES.
