Network Nuclei Flashcards

1
Q

Lc

A

Locus coeruleus

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2
Q

nR

A

Raphe nuc.

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3
Q

PPN

A

Pronto-peduncular nuc

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4
Q

NB

A

Nucleus Basalis (of Meynert)

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5
Q

ILn

A

Intralaminar nuc.

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6
Q

TRn

A

Thalami reticular nuc.

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7
Q

T-Mn

A

Tubers-mamillary nucleus

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8
Q

VTA

A

Ventral tegmental area

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9
Q

nAc

A

Nucleus accumbens

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10
Q

SN

A

Substantia nigra

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11
Q

ARAS

A

Ascending reticular activating system

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12
Q

ARAS includes what two nuclei?

A

Intralaminar thalami nuclei (ILn) and thalami reticular nucleus (TRn)

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13
Q

What is the significance of the thalamic ARAS?

A

All 5 of the single source divergent networks communicate via axonal projections with the thalamic ARAS

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14
Q

Neurons from the TRn tend to be

A

GABAergic, or inhibitory

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15
Q

Main nuclei of the Norepinepherine/Noradrenaline (NE/NA) system

A

Locus coeruleus

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17
Q

The NE/NA system with ____ nucleus projects everywhere except:

A

Lc nucleus
DOES NOT: Brainstem and spinal cord

DOES:
Cerebellum
Hippocampus
Hypothalamus
Cerebrum
Amygdala
Thalamus (ARAS)
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18
Q

Locus soeruleus (Lc) is a paired brainstem nuclei in what location?

A

Rostral pons

19
Q

Locus coeruleus is associated with what neurotransmitter

A

Norepinephrine/noradrenaline

20
Q

Action of Norepinephrine/noradrenaline is [excitatory/inhibitory/both]

A

Both

21
Q

The main nuclei of the histamine (His) system?

A

Tuberomammillary nucleus (TMn)

22
Q

Location of the Tuberomammillary nucleus (TMn)?

A

Hypothalamus

23
Q

The effects of histamine in the CNA are [excitatory/inhibitory/both]

A

Excitatory only

24
Q

Histamine system with ___ nucleus projects everywhere except:

A

TMn
DOES NOT: hypothalamus, amygdala

DOES: Brainstem
Spinal cord
Hippocampus
Thalamus
Cerebellum
Cerebrum
Thalamus (ARAS)
25
Q

unique functions of histamine system:

A

Energy homeostasis

Circadian rhythms

26
Q

Main nuclei of the Serotonin (5-HT) System?

A

Raphe nuclei (nR)

27
Q

Where is the Raphe nuclei (nR) located?

A

Brainstem extending from pons to midbrain

28
Q

5HT system with ____ nucleus projects everywhere EXCEPT:

A

nR
DOES NOT: hippocampus, amygdala

DOES: Brainstem
Spinal cord
Cerebellum
Hypothalamus
Cerebrum
Thalamus (ARAS)
29
Q

Unique Function of the 5HT system:

A
Behavioral inhibition
Negative emotions along with NE/NA
Deep sleep (non-REM) along with NE/NA
30
Q

5HT is [excitatory/inhibitory/both]

A

Both

31
Q

Unique functions of NE/NA system:

A
  • Processes negative emotions along with 5-HT
  • Deep sleep (non-REM) along with 5-HT
  • Cognitive performance
32
Q

Main nuclei of the Acetylcholine (ACh) System?

A

Nucleus basalis (NB) and Pontopeducular nucleus (PPN)

33
Q

ACh system with ___ and _____ nucleus projects everywhere EXCEPT

A

NB and PPN
DOES NOT: cerebellum, amygdala, brainstem, spinal cord

DOES: 
Hippocampus
Hypothalamus
Cerebrum
Thalamus (ARAS)
34
Q

Location of the nucleus basalis (NB)

A

Below anterior part of the thalamus and lenticular nucleus within the anterior perforated substance

35
Q

Where is the pontopeduncular nucleus (PPN) located?

A

Midbrain, adjacent to substantia nigra

36
Q

Unique function of the ACh system?

A

Control of REM sleep

37
Q

Is the ACh system [excitatory/inhibitory/both]?

A

Excitatory only at NMJ and both at the brain

38
Q

Dopamine (DA) system is associated with what nuclei?

A
Nucleus accumbens (nAc)
Ventral tegmental area (VTA)
Substantial nigra (SN)
39
Q

Where is the VTA and substantia nigra?

A

Midbrain

40
Q

Where is the nAc?

A

Basal forebrain

41
Q

DA system with _____ and _____ and ____ nuclei projects everywhere except:

A

VTA, nRC, SN
DOES NOT: cerebellum, brainstem, spinal cord

DOES: Cerebrum
Hypothalamus
Hippocampus
Amygdala
Thalamus (ARAS)
42
Q

Unique DA system functions:

A
  • “positive reward network”

- Modulates positive emotions