Nervous System: Efferents Flashcards
Three types of neurons
- Afferent -????
- Efferent - lead from brain/spinal cord to effector
- Interneuron (association) - contained w/in the CNS
CNS
- Brain
- Spinal cord
PNS
- Efferent
- Afferent
Efferent
- Autonomic
- Somatic
Afferent
- Visceral
- Sensory
Autonomic
- Parasympathetic
- Sympathetic
Somatic Nervous System
- cell bodies lie w/in the CNS
- direct connection to skeletal muscle
- Ach released at neuromuscular junction onto nicotinic receptor
- always excitatory (allow more Na+ in than K+ out = depolarization)
Autonomic NS
- innervates all tissue except skeletal muscle
- two neurons b/t CNS & effector
—1st neuron’s soma w/in CNS
—NT at synapse always Ach onto nicotinic receptors - either excitatory or inhibitory (effect
Sympathetic
Ganglia lie close to CNS
- Utilize NorEpi at postganglionic synapse
- Adrenergic receptor at postganglionic synapse
Parasympathetic
Ganglia close to innervated tissue
- Utilize Ach at postganglionic synapse
- Muscarinic receptors at postganglionic synapse
Tissue: Bronchial
Sympathetic:
*Beta 2
- Increases strength
Parasympathetic:
*M
- Contract
Dual innervation
Many tissues affected by both sympathetic & parasympathetic NS
Tissue: Heart
Sympathetic:
*Beta 1
- Increases rate
- Increases strength
Parasympathetic:
*M
- Decreases rate
Initially treated asthma patients w/ Epi…
But targeted ALL adrenergic receptors
- need a target response towards Beta 2 (Beta 2 agonist)
Synapses in the Autonomic Neurons
- Many autonomic neurons lack traditional bouton endings at a synapse
- Instead, swellings called VARICOSITIES influence effectors cells
- AP initiates neurotransmitter released into ECF
- NT impact a larger area (not limited to cleft region)
- Effector response is slower acting but for longer duration