Nervous System Flashcards
Neurons
Nerve cells specialised for communication with each other. They have long extensions that help them respond to stimulation from other neurons and communicate with them (dendrites)
Neuronal/cell membrane
Separates the inside from the outside of the cell, encases the entire neuron
Made up of two layers of fat molecules called the lipid bilayer with embedded proteins to help it perform its functions
Cell body (soma)
Central region of the neuron that manufactures new cell components, consisting of small and large molecules.
It is the main site where proteins are synthesised and it provides continuous renewal of cell components.
It is where the cells metabolic processes take place
Dendrites
Extensions for receiving information from other neurons. These receiving parts gradually taper from the cell body region, much as a branch on a tree narrows as it extends outwards
Axon (nerve fibre)
Portion of the neuron that send signals/nerve impulses. These long tail-like extensions are usually very thin near the cell body. This narrowness creates an area that is easily activated by incoming signals
Synaptic vesicles
Membranes that store various neurotransmitters that are released at the synapse
Axon terminal
Knoblike structure at the far end of the axon.
Neurotransmitters
Chemical messengers specialised for communication and released at the synapse
Synapse
Space between two connecting neurons through which messages are transmitted
Synaptic cleft
Space between two connecting neurons where neurotransmitters are released
Glial cells (definition)
Support cells in the nervous system that play a role in the formation of myelin and the blood–brain barrier, respond to injury and remove debris.
The most abundant of glial cells are astrocytes.
Node (of Ranvier)
Gap in the myelin sheath of an axon, which helps the conduction of nerve impulses.
Astrocytes
A type of glial cell in the CNS. The most abundant. A single astrocyte interacts with as many as 300 000–1 000 000 neurons.
Astrocytes communicate closely with neurons, increase the reliability of their transmission, control blood flow in the brain, and play a vital role in the development of the embryo.
We can find astrocytes in abundant supply in the blood–brain barrier, a protective shield that insulates the brain from infection by bacteria and other intruders.
Oligodendrocyte
Glial cell in the CNS concerned with production of myelin that promotes new connections among nerve cells and releases chemicals to aid in healing
Myelin sheath
Glial cell-wrappers around axons that act as insulators of the neuron’s signal. This sheath contains numerous gaps all the way along the axon called nodes, which help the neuron conduct electricity more efficiently
Resting potential
Electrical charge difference (–60 millivolts) across the neuronal membrane, when the neuron is not being stimulated or inhibited
Action potential
When a neuron is at rest, there are positive and negative ions on both sides of the membrane. During an action potential, positive ions rush in and then out of the axon. This process occurs along the axon until the axon terminal releases a neurotransmitter
Qualities of action potential:
1. All or nothing. Similar to the firing of a gun; when we pull the gun’s trigger, it either fires with maximum power or it does not fire at all.
2. Regenerative, meaning that, once started, the process is self-perpetuating; the action potential continues all the way down to the axon terminal.
3. The mechanism of action potentials differs from that of graded potentials. During an action potential, a positive charge flows rapidly into the axon and then rapidly flows out, bringing the membrane potential slightly below its original resting value
Threshold
Membrane potential necessary to trigger an action potential
Absolute refractory period
Time during which another action potential is impossible; limits maximal firing rate
Receptor sites
Locations that uniquely recognise a neurotransmitter
Reuptake
Means of recycling neurotransmitters
Graded potential
Postsynaptic potentials that can be excitatory or inhibitory, depending on whether positively or negatively charged particles flow across the neuronal membrane and in which direction they flow
Function of nervous system
Information processing (taking in information, processing it to determine significance and acting on it)
Explain what happens during a reflex action (e.g. touching a hot surface)
- Sensory receptors in the fingers respond
- Afferent (sensory) nerve fibres carry the message to the spinal cord
- Synapse passes message to interneuron in the spinal cord, which relay the message to efferent nerve fibres
- Efferent (motor) nerve fibres send a message to the muscles located in the hand
Afferent neurons
Sensory neurons that carry nerve impulses from sensory stimuli towards the central nervous system and brain
Efferent neurons
Motor neurons that carry neural impulses away from the central nervous system and towards muscles to cause movement
3 steps in neurotransmission
- Release of the neurotransmitter from the axon terminal into the synaptic cleft
- Binding of the neurotransmitter to its receptor site
- Halting neurotransmission by either the chemical breakdown of the neurotransmitter or by reuptake of the neurotransmitter back into the axon terminal—a process by which the synaptic vesicle engulfs the neurotransmitter
Glutamate (function)
Main excitatory neurotransmitter in the nervous system; participates in the relay of sensory information and learning
Gamma-aminobutyric acid (GABA) (function)
Main inhibitory neurotransmitter in the nervous system. Alcohol and anxiety drugs increase GABA activity.