Nervous anatomy and physiology Flashcards
Tonic labyrinthine reflexes
Keep the axis of the head in relationship with the rest of the body
Uses information from maculae and neck proprioceptors
Dynamic righting reflexes
Stop you falling when you trip
Most profound in cats
Static reflex
When you tilt your head, the eyes intort/ extort to compensate
A vestibulo-occular reflex
In the PNS, the myelin sheath is formed by…
Schwann cells
In the CNS, the myelin sheath is formed by…
Oligodendrocytes
Collections of neuronal cell bodies, buried within the white matter of the brain are called…
Basal ganglia
The collection of white matter tracts through which the hemispheres communicate with each other is called…
Corpus callosum
Internal lobe, between the frontal and temporal lobes is called…
The insula
Area 4 (function and location)
Primary motor cortex: motor homunculus
precentral gyrus
Area 44, 45
function and location
Broca’s area of motor speech
inferior frontal gyrus
Area controlling cognitive functions of higher order-intellect, judgement, prediction, planning
Prefrontal cortex
Areas 3, 1, 2
function and location
Primary sensory area: sensory homunculus
post central gyrus
Area of the brain responsible for interpretation of general sensory info and conscious awareness of opposite half of body
Superior parietal lobule
Area of the brain which is the interface between somatosensory cortex and visual + auditory association areas
Inferior parietal lobule/ global association area
*In dominant hemisphere, contributes to language functions
Areas 41, 42
Primary auditory cortex
superior temporal gyrus
Location of the auditory association area
Posterior to areas 41, 42
In the dominant hemisphere the auditory association area is Wernicke’s area
Area of the brain responsible for the conscious appreciation of smell
Inferior surface of the temporal lobe
Receives fibres from the olfactory tract
Area 17 (function and location)
Primary visual cortex
medial surface of the occipital lobe, either side of the calcarine sulcus
Area of the brain involved in memory and the emotional aspects of behaviour
Limbic lobe (a functional area)
Contents of the limbic lobe
Cingulate gyrus
Hippocampus
Hypothalamus
Amygdala
Location of the hippocampus
Medial aspect of temporal lobe
Function of Broca’s area
Motor speech
Wernicke’s area
function and location
The auditory association area in the dominant hemisphere
Necessary for recognition of spoken word
Aphasia
Problems with speech due to damage of one or more speech areas in the brain
Myelinated axon fibres connecting corresponding areas of the two hemispheres together are called…
Commisural fibres
Myelinated axon fibres connecting one part of the cortex with another are called…
Association fibres
may be short or long
Myelinated axon fibres running between the cerebral cortex and various subcortical centres (below), passing through the internal capsule are called…
projection fibres
The narrow area between the thalamus and the caudate/lentiform nuclei, made up of projection fibres passing to and from the cerebral cortex
The internal capsule
Blood supply of the internal capsule
Middle cerebral artery
so is frequently affected in a stroke
Tract carrying motor impulses from cortex to skeletal muscles
Corticospinal/ pyramidal
Tract carrying sensory information (other than pain and temperature)
Posterior/ dorsal column
Tract carrying pain and temperature sensory information
Lateral spinothalamic tract
Fibres of the corticospinal tract synapse…
In the ventral horn
The corticospinal tract decussates…
At the decussation of the pyramids in the inferior medulla
No. of neurons making up the motor pathway
2:
UMN
LMN
(synapse in the ventral horn at the level where they exit)
The posterior/dorsal column decussates…
In the medulla
After decussation, the posterior/dorsal column is called…
The medial lemniscus
The lateral spinothalamic tract decussates…
At the level of entry
For ascending spinal tracts, which order neuron decussates?
2nd order neuron
Effect of an UMN lesion on tone…
Spasticity
Increased tone
Effect of a LMN lesion on tone…
Flaccidity
Decreased tone
Effect of a LMN lesion on reflexes
Areflexia
absent reflexes
Effect of an UMN lesion on reflexes
Hyper-reflexia
Exaggerated reflexes
EEG
ElectroEncephaloGram
Records activity of underlying neurons
Circadian rhythm
A biological system showing oscillations of ~24hrs
Demonstrated by the SCN (suprachiasmatic nuclei) of the hypothalamus - the “master clock”
Result of UMN lesion above the decussation
Contralateral spastic paralysis and hyperreflexia
Result of UMN lesion below the level of decussation
Ipsilateral spastic paralysis and hyperreflexia
Result of LMN lesion
Ipsilateral flaccid paralysis and areflexia
Melatonin is released by ……………… stimulated by ……………..
Melatonin is released from the pineal gland, stimulated by activity in the SCN (Suprachiasmatic nuclei) of the hypothalamus
Feeling of sleepiness is produced by which hormone?
Melatonin
The neurotransmitter required for wakefulness is called…
Orexin
On an EEG recording, frequency increases with…
Neuronal excitation
E.g.
anaesthesia –> sleep –> awake –> epilepsy
On an EEG recording, amplitude increases with…
decreasing neuronal excitation
Cognition definition
The integration of all sensory information to make sense of a situation
Function of the hippocampus (in learning and memory)
Formation of memories
Function of the cortex (in learning and memory)
Storage of memories
Function of the thalamus (in learning and memory)
Searches and accesses memories
The limbic system is responsible for what types of behaviour?
Instinctive (thirst, hunger, sex etc.)
Emotive (driven by reward/ punishment) - gives emotional significance to events, essential for memory
The ability to hold experiences in the mind for a few seconds. Based on different sensory modalities
Immediate/ sensory memory
Type of memory associated with reverberating circuits
Short term memory,
Often called working memory
Used for tasks such as dialling a phone number
Type of memory associated with chemical adaptation at the presynaptic terminal
Intermediate long-term memory
Used to remember what you did last weekend etc…
Type of memory associated with structural changes in synaptic connections
Long-term memory
Used to remember childhood friends etc…
Anterograde amnesia
Cannot form new memories
Can be short lived or permanent following an injury
Retrograde amnesia
Cannot access (more recent) old memories
Occurs if thalamus damaged
Changes in structure in long-term memory
- increase in number of presynaptic terminals
- increase of neurotransmitter release sites
- increase of neurotransmitter vesicles stored and released
Types of long term memory
Declarative/Explicit: for events, rules and language (relies heavily on hippocampus)
Procedural/Reflexive/Implicit: for acquired motor skills (independent of hippocampus)
Conversion of short-term memories to long-term memories
definition and mechanism
Consolidation
Strengthening of synaptic connections through repetition
Which cranial nerves emerge from the pontomedullary junction
VI, VII, VIII
Function of the olive
Contains the inferior olivary nucleus
What structure does the “open” part of the medulla open onto?
What part of the medulla is this?
The 4th ventricle
The posterior, superior medulla
The “closed” part of the medulla is a continuation of what structure?
What part of the medulla is this?
The central canal of the spinal cord
The posterior, inferior medulla
Function of the cerebellar peduncles
Attach the cerebellum to the brainstem
Attachments of the middle cerebellar peduncle
Cerebellum
Pons
The surface projections visible of the surface of the hypothalamus are called…
The mammillary bodies
The midline structure connecting the two cerebellar hemispheres is called…
The vermis
The ventricular space lying immediately anterior to the cerebellum is the…
4th ventricle
The part of the cerebellum above the foramen magnum…
The cerebellar tonsil
In a sudden drop in intracranial pressure, the cerebellar tonsils may herniate through the foramen magnum, this is called…
Cerebellar coning
The fissure separating the two cerebral hemispheres is called…
The medial longitudinal fissure
The structure connecting the two cerebral hemispheres is called the…
Corpus callosum
composed of commissural fibres
The fold of dura mater separating the cerebellum from the cerebral hemispheres is called…
Tentorium cerebelli
At what level does the spinal cord terminate in an adult?
L1-2
At what level does the spinal cord terminate in a new-born?
L2-3
At what vertebral level does the dura mater terminate
S2
At what vertebral level does the arachnoid mater terminate?
S2
Fate of the pia mater, inferior to the spinal cord…
Becomes the filum terminalis
What occupies the space btw the termination of the spinal cord and the dura/arachnoid mater?
Conus medularis and cauda equina (spinal nerve roots L2 -Cc1)
Correct vertebral level of a lumbar puncture on an adult
Between L3 - 4 (with adult in a foetal position)
How many pairs of spinal nerves are there?
31
8 cervical 12 thoracic 5 lumbar 5 sacral 1 coccygeal
From which arteries do the left and right vertebral arteries arise?
Subclavian
Vertebral level of bifurcation of the common carotid artery
C3/4
Which part of the brainstem does the basilar artery overlie?
Pons