Nerve Flashcards
Nerve fibers
- axons enveloped by a sheath cell called a Schwann cell
- small axons usually unmyelinated and thicker are myelinated and have Schmidt-Lanterman clefts and nodes of Ranvier
unmyelinated fibers
-enclosed in a simple fold of a Schwann cell, some very thin can share a fold
Myelinated fibers
- thicker axons
- Schwann cell wraps around axon multiple times
- squeezes out most of the cytoplasm except some places-schmidt-lanterman clefts
- nodes of Ranvier indicate end of one Schwann and the beginning of another, which is covered by interdigitating processes
Nerves
- bundles of fibers that contain myelinated and unmyelinated axons and motor and sensory fibers
- surrounded by CT
epineurium
- outermost layer
- binds bundles or fascicles together into nerves
- dense irregular to loose CT
perineurium
- prominent layer, most visible
- modified fibroblasts (epithelioid myofibroblasts)- form tight junctions with each other and collagen fibers
- groups nerve fibers into bundles or fascicles
- selective diffusion (blood-nerve) barrier
endoneurium
-delicate layer of reticular fibers produced by Schwann cells
ganglia
- peripheral clusters of cell bodies of neurons that are surrounded by satellite cells
- sensory and autonomic can be easily distinguished at the level of the light microscope
sensory ganglia
- contain cell bodies of psuedonunipolar neurons
- no synapses within ganglion
- numerous myelinated fibers
- neurons have a central nucleus and a regular ring of satellite cells-protective capsule
- single cell process
pseudounipolar neuron
-oneish dendrite and cell body off to side of axon
bipolar neuron
- 2 dendrites
- cell body in middle of axon
multipolar
- multiple dendrites
- cell body at top
- one axon
autonomic ganglia
- contain cell bodies of multipolar neurons
- synapses in ganglion
- numerous unmyelinated fibers
- neurons have an acentric nucleus and smaller cell bodies
- multiple cell processes, single axon
specialized termini
- motor end plate
- free endings
- meissner’s corpuscles
- pacinian corpuscles
- muscle spindles
motor end plate
- ending of motor neuron axons
- synaptic vesicles at expanded axonal terminus
- postsynaptic membrane has junctional folds and acetylcholine receptors
sensory receptors
- externoreceptors
- enteroreceptors
- proprioreceptors
- free endings
- encapsulated endings
free endings
- bare axons are important for sensations from the skin of hot, cold, itching, touch, and pain
- can go to a merkel cell?
encapsulated endings
-meissners and pacinian corpuscles and muscle spindles
MERKEL??**
Meissner’s Corpuscles
- dermal papillae of hairless skin
- 150 microns
- touch receptors responsive to low frequency stimuli
Pacinian Corpuscles
- hypodermis and deeper dermis of skin
- 1mm or larger
- mechanoreceptors that respond to pressure and vibration
- formed from concentric layers of Schwann cells
Muscle Spindles
- proprioceptor
- encapsulated receptors in skeletal muscle
- contain thin specialized muscle fibers called intrafusal fibers in a fluid filled space
- sensory nerve fibers exiting the capsule send signals about the extrafusal muscle fiber length and relay this information to the spinal cord where it plays a role in reflexed involved in maintaining posture and coordinating walking