NER Flashcards
1
Q
NER
Damage repaired
A
Removes damaged bases as part of an oligonucleotide fragment
For pyrimidine dimers and bulky adducts
2
Q
Major UV photoproducts
A
Cyclobutane pyrimidine dimer
Cyclobutane thymine dimer
Produce DNA kinks
3
Q
Minor photo product
A
6-4 photoproduct
Eg. TC 6-4 PP
4
Q
UvrA structure:
2____________domains
Helix____________domain
2__________binding domains
A
Zinc finger
Turn helix
ATP
5
Q
Cockayne syndrome, TTD and XP are all:
A
Autosomal recessive
