Neprilysin inhibitor & Aldosterone antagonists

Question 1

Neprilysin Inhibitor drug names

Answer 1

Sacubitril and Valsartan (Entresto)

Question 2

Sacubitril inhibits what

Answer 2

neutral endopeptidase

inhibits breakdown of natriuretic peptides (and AT2)

Increases salt and water excretion

Question 3

Neprilysin inhibitor treatment

Answer 3

chronic heart failure
- superior benefits vs. ACE inhibitors

Question 4

Aldosterone antagonists drug names

Answer 4

Spironolactone (aldactone)
Elperenone (Inspra)

Question 5

Aldosterone antagonists treatment of what

Answer 5

treatment of chronic heart failure, hypertension, chronic kidney disease associated with DM, hyperaldosteronism

used more in middle to late heart failure

act like mild diuretics (trade sodium for potassium)
- Hold on to more potassium and get rid of sodium HYPERKALEMIA

Question 6

Aldosterone antagonists other side effects

Answer 6

Hypotension

Spironolactone blocks other hormones in body (gynecomastia)

Eplerenone does not cause gynecomastia but is more expensive

Question 7

Neprilysin risks

Answer 7

Higher risk of hypotension and angioedema than with ACE inhibitors

lower risk of cough and renal dysfunction