Anti-arrhythmics

Question 1

Anti-arrhythmic MOA

Answer 1

Correct or prevent arrhythmia

Question 2

Class I

Answer 2

Na+ channel blockade

Question 3

Class II

Answer 3

Beta-blockade (Non-DHP’s)

Question 4

Class III

Answer 4

Prolonged repolarization (Amiodarone)
- high risk of causing torsade (TDP)

Question 5

Class IV

Answer 5

Ca2+ channel blockade (Non-DHP’s)

Question 6

TDP or torsade

Answer 6

Life threatening heart rhythm disturbance, ventricles out of rhythm.

Question 7

Amiodarone

Answer 7

Lower risk of TDP then other antiarrythmics

acts as all classes but technically it is class III

Question 8

Amiodarone side affects

Answer 8

bradycardia, dermatologic toxicity, drug interactions, pulmonary fibrosis, pneumonitis, cardiotoxicity, liver toxicity, ophthalmic toxicity

Half-life = 25-100 days

Question 9

Rule of 5

Answer 9

Takes 5 half-lives of drug to be fully out of your body

Question 10

Steady state of a drug

Answer 10

Moment drug therapy where the amount that is being put in the body with every dose is perfectly replacing the amount that is taken b/w doses

Question 11

Flecainide class

Answer 11

1C

Question 12

Flecainide use

Answer 12

A-fib (patients without structural heart disease)

Question 13

Flecainide side affects

Answer 13

dizziness, visual disturbances, dyspnea, QT prolongation/TDP

Question 14

Flecainide and TDP

Answer 14

Low risk of TDP in patients without structural heart disease)

Question 15

Which drug may require the use of a loading dose

Answer 15

Amiodarone