nephrotox Flashcards
what are the three main regions of the kidney
whats the functional unit of the kidney
what are the regions of the nephron
what are the key functions of the kidney
why is the kidney so susceptible to toxicity (4 reasons)
what is AKI and what is it based on
what can cause the decline in GFR in AKI?
t/f: AKI related mortality is one of the lowest mortality rates
whats the difference between the aquisition of AKI in low income vs high income countries
what is the glomerular filtration rate normally dependent on
what can decrease the GFR in acute renal failure
whats the difference between acute kidney injury and chronic kidney disease
t/f: if you have AKI you’re less likely to develop CKD
why are patients with AKI more likely to develop CKD (2 reasons)
GFR is a marker for kidney damage. what does it tell you?
what does serum creatinine tell you about kidney damage
what does proteinuria tell you about kidney damage
what does blood urea nitrogen tell you about kidney damage
what does cystatin C tell you about kidney damage
what does it mean that nephrotox is a dose limiting adverse effect of cisplatin
what does cisplatin do (to DNA)
what class of genotoxic agents does cisplatin belong to
how does the cell handle cisplatin
what is cisplatin used for clinically. how many of these patients experience kidney damage?
t/f: combination regimens reduce risk of renal toxicity
how do you manage cisplatin induced AKI
why is cisplatin so toxic to the kidney
what is the pathway from cisplatin exposure to AKI or CKD
whats the relationship between copper, the copper transporter 1, and cisplatin
examples of aminoglycosides include:
what are aminoglycosides used for? how are they excreted?
what family does gentamicin fall into?
how does gentamicin accumulate in tubular cells?
how does gentamicin trigger ER stress and the UPR?
how does gentamicin lead to apoptosis?
how does gentamicin get redistributed in the cytosol? how does this contribute to its renal tox?
what are the consequences of tubular epithelial damage? what effect does it have on pressure?
what are the different: gentamicin has only one mechanism of toxicity
what are the different mechs of gentamicin toxicity
whats the difference between direct cellular injury and immune mediated injury
what can lead to membranous nephropathy
if you immediately get rid of the thing causing the membranous nephropathy, does your albumin and proteinurea go back to normal right away?
what are the three different models of d penicillamine induced membranous nephropathy
how does a membranous neuropathy capillary compare to a normal one
what kind of toxicity does aristolochic acid cause?
what is the aristoclochic acid mech of toxicity?
whats the difference in toxicity between AA-1 and AA-2
how does sulfamethoxazole induce nephropathy
