Nephrotic vs Nephritic

Question 1

3 main pathophys steps with nephrotic syndrome

Answer 1

complement activation –> podocyte injury = proteinuria –> damage glomerular epithelial cells

Question 2

main patho notes (4) nephritic

Answer 2

macrophage–> crescent from bowmans space –> glomerular sclerosis –> fibrosis

Question 3

___ syndrome contains GN that are more proliferative

Answer 3

nephritic (RPGN, Post infectious GN, Wegners, Microscopic Polyangia etc)

Question 4

__ syndrome contains GN that are more non proliferative

Answer 4

nephrOtic: minimal change GN, membranous GN, focal segmental GN

Question 5

Classic nephritic syndrome sx

Answer 5

hematuria, oliguria, azotemia, HTN

Question 6

azotemia

Answer 6

build up of nitrogen products - usually urea

Question 7

oliguria

Answer 7

small amounts of urine produced

Question 8

“coca cola” urine syndrome

Answer 8

nephritic

Question 9

What does inflammation with nephritic syndrome lead to?

Answer 9

GFR drops, NA filtrate drops, renin released = increase BP via RAAS

Question 10

hyalization

Answer 10

deposition of crystalline protein matrix = builds up BM

Question 11

4 nephrotic hallmarks

Answer 11

TONS of serum pro lost, hyperlipidemia, sustained proteinuria, hyalization, lipiduria, hypercoagulabe, edema

Question 12

___ retention happens with Nephrotic syndrome

Answer 12

sodium, due to decreased reabsorption at tuble?

Question 13

3 main disease associated with nephrotic

Answer 13

minimal change GN, focal segmental Glomerulosclerosis, membranous glomerulonephritis

Question 14

secondary renal diseases - nephrotic

Answer 14

SLE, HEP B and C, HIV, DM, Malignancy

Question 15

main disease 5 with nephritic

Answer 15

post strepto GN, Iga nephropathy, RPGN(goodpasteurs), membranoproliferative glomerulonephritis, Henoch-Scholein purpura