Nephrotic Syndromes Flashcards
Five Hallmarks of Nephrotic Syndrome
- Hypoalbuminemia
- Edema
- Hypercoagulable state
- Hyperlipidemia
- Hypercholesterolemia
Proteinuria is > _____ /day
3.5 g
Hypercoagulable state is caused by loss of __________
ATIII
Most common cause of nephrotic disease in children
Minimal Change Disease
Associated with Hodgkin Lymphoma
Minimal Change Disease
Effacement of foot processes on E&M
Minimal Change Disease
FSGS
Selective proteinuria, but not loss of immunoglobulin
MCD (“Minimal” Loss)
Excellent response to steroids (damage is mediated by cytokines from T cells)
MCD
If not treated, MCD would progress to _______, which is one way to think about why these two diseases are both associated with effacement of foot processes
FSGS
Most common cause of nephrotic syndrome in AA and Hispanics
FSGS
Associated with HIV infection, heroin abuse, massive obesity, interferon treatment, sickle cell, and CKD due to congenital absence or surgical removal
FSGS
No immune complexes, negative IF
MCD and FSGS
Most common cause of nephrotic syndrome in Caucasian adults
Membranous Nephropathy
Associated with Hepatitis B/C, solid tmors, most common nephrotic presentation of SLE, or drugs (NSAIDs, pencillamine)
Membranous Nephropathy
Thick glomerular basement on H&E
Membranous Nephropathy
