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Renal/Cardio > Nephritic Syndrome > Flashcards

Nephritic Syndrome Flashcards

1
Q

Presents 2-3 weeks after infection as hematuria (cola-colored urine), oliguria, hypertension, and periorbital edema

A

PSGN - most frequently in children; resolves spontaneously, may lead to renal failure in adults

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2
Q

Hypercellular, inflamed glomeruli on H&E

“lumpy-bumpy” appearance

A

PSGN

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3
Q

Granular Immune Deposition

A

PSGN & DPGN

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4
Q

Subepithelial IC humps and subendothelial deposits

A

PSGN

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5
Q

Occurs with nephritogenic strains (that carry M protein)

A

PSGN

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6
Q

Linear IF pattern

A

Goodpasture’s

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7
Q

Antibody against collagen in GBM and alveolar basement membrane

A

Goodpasture’s, Type II HS

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8
Q

“Wire looping” of capillaries, subendothelial and sometimes GBM deposits with C3 deposition (low complement)

A

DPGN

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9
Q

Most common cause of death in SLE

A

DPGN

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10
Q

SLE and MPGN can present as nephrotic and _______

A

DPGN

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11
Q

Negative IF (pauci-immune)

A

Wegener’s - c-ANCA (look for hemoptysis, sinusitis)
Microscopic polyangiitis - p-ANCA
Churg-Strauss - Eos, granulomas, asthma

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12
Q

Cresent-moon shapes consisting of fibrin, plasma proteins (e.g. C3b) with glomerular parietal cells, monocytes, and macrophages

A

RPGN - rapidly deteriorating renal function in days to weeks

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13
Q

Several disease processes result in RPGN -

A
  1. Goodpasture’s
  2. Wegener’s
  3. Microscopic Polyangiitis
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14
Q

Related to Henloch Schonlein purpura (kidney limited) - mesangial proliferation, IgA deposits

A

Berger’s diease, IgA nephropathy

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15
Q

Most common nephropathy worldwide

A

IgA/Berger’s

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16
Q

Episodic gross or microscopic hematuria with RBC casts usually following a mucosal infection

A

IgA/Berger’s

17
Q

Inherited defect in type IV collagen, X-linked

A

Alport’s syndrome

18
Q

Basketweave appearance on EM, thinning of GBM

A

Alport’s syndrome

19
Q

Isolated hematuria, sensory hearing loss, and ocular disturbances

A

Alport’s syndrome

Renal/Cardio (7 decks)

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