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Renal > Nephrotic Syndrome > Flashcards

Nephrotic Syndrome Flashcards

1
Q

Reason for hypercoagulable state in NS?

A

Lost anti-thrombin III in urine (increased risk for thromboembolism)

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2
Q

Most common NS in children?

A

Minimal change

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3
Q

Most common NS in Hispanics and African Americans?

A

FSGS

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4
Q

Most common NS in Caucasian adults?

A

Membranous

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5
Q

Most commonly involved organ in amyloidosis?

A

Kidney

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6
Q

2 diseases assoc with loss of foot processes?

A

Minimal change, FSGS

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7
Q

Only NS that responds to steroids?

A

Minimal change

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8
Q

Assoc with HIV, heroin use, sickle cell?

A

FSGS

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9
Q

Assoc with Hodgkin’s lymphoma?

A

Minimal change

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10
Q

Assoc with hep B and C?

A

Membranous, type I membranoproliferative

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11
Q

Assoc with SLE?

A

Membranous

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12
Q

Histo in minimal change?

A

LM normal; EM shows effacement of foot processes

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13
Q

Histo in FSGS?

A

LM shows dense pink collagen in glom, segmental sclerosis, hyalinosis; EM shows effacement of foot processes

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14
Q

Histo in membranous?

A

LM shows diffuse capillary/BM thickening; EM shows “spike and dome” appearance with subepithelial deposits; IF is granular

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15
Q

May present with nephritic syndrome?

A

Membranoproliferative

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16
Q

Tram track appearance?

A

Type I membranoproliferative

17
Q

Intramembranous deposits?

A

Type II membranoproliferative

18
Q

Subepithelial deposits?

A

Membranous

19
Q

Subendothelial deposits?

A

Type I membranoproliferative

20
Q

Assoc with C3 nephritic factor?

A

Type II membranoproliferative

21
Q

Change seen in DM?

A

Hyaline arteriolosclerosis due to non-EZ glycosylation

22
Q

Kimmelstiel Wilson nodules?

A

Eosinophilic nodular glomerulosclerosis due to sclerosis of mesangium

23
Q

Tx of DM NS?

A

ACEIs

24
Q

Location of amyloid causing NS?

A

Mesangium

25
Q

Triggered by recent infection (URI) or immune stimulus (atopic dermatitis)?

A

Minimal change

26
Q

May be caused by massive obesity?

A

FSGS

27
Q

1st change seen in DM nephropathy?

A

Microalbuminemia

Renal (5 decks)

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