Nephrotic Syndrome Flashcards
Reason for hypercoagulable state in NS?
Lost anti-thrombin III in urine (increased risk for thromboembolism)
Most common NS in children?
Minimal change
Most common NS in Hispanics and African Americans?
FSGS
Most common NS in Caucasian adults?
Membranous
Most commonly involved organ in amyloidosis?
Kidney
2 diseases assoc with loss of foot processes?
Minimal change, FSGS
Only NS that responds to steroids?
Minimal change
Assoc with HIV, heroin use, sickle cell?
FSGS
Assoc with Hodgkin’s lymphoma?
Minimal change
Assoc with hep B and C?
Membranous, type I membranoproliferative
Assoc with SLE?
Membranous
Histo in minimal change?
LM normal; EM shows effacement of foot processes
Histo in FSGS?
LM shows dense pink collagen in glom, segmental sclerosis, hyalinosis; EM shows effacement of foot processes
Histo in membranous?
LM shows diffuse capillary/BM thickening; EM shows “spike and dome” appearance with subepithelial deposits; IF is granular
May present with nephritic syndrome?
Membranoproliferative
Tram track appearance?
Type I membranoproliferative
Intramembranous deposits?
Type II membranoproliferative
Subepithelial deposits?
Membranous
Subendothelial deposits?
Type I membranoproliferative
Assoc with C3 nephritic factor?
Type II membranoproliferative
Change seen in DM?
Hyaline arteriolosclerosis due to non-EZ glycosylation
Kimmelstiel Wilson nodules?
Eosinophilic nodular glomerulosclerosis due to sclerosis of mesangium
Tx of DM NS?
ACEIs
Location of amyloid causing NS?
Mesangium
Triggered by recent infection (URI) or immune stimulus (atopic dermatitis)?
Minimal change
May be caused by massive obesity?
FSGS
1st change seen in DM nephropathy?
Microalbuminemia
