Nephrotic/Nephritic Flashcards
What is the definition of microalbuminuria?
30-300 mg of albumin per day
Which autoantibody is most associated with malignancy in patients with membranous nephropathy?
THSD7A
What will the serum and tissue PLA2R staining be in remission (and early disease) of membranous nephropathy?
Serum NEG
Tissue POS
What is the 30/30/30 rule in membranous nephropathy?
30% have spontaneous remission
30% have persistent proteinuria
30% have progressive kidney disease
What is the modified Ponticelli regimen for membranous nephropathy?
Steroids (month 1, 3, 5)
Cyclophosphamide (month 2, 4, 6)
Which FSGS variant is most treatment responsive?
Tip variant
Which FSGS variant is least treatment responsive?
Collapsing variant
How does Primary FSGS differ from Secondary FSGS with the following:
- Acuity of nephrotic syndrome?
- Presence of renal insufficiency?
Primary is more acute and less likely to present with renal insufficiency compared with Secondary FSGS
What is the treatment for Primary FSGS?
Steroids (PO)
What is the treatment for Secondary FSGS?
Treatment of underlying condition
What agent should be added to those with Primary FSGS who are not able to be weaned from steroids?
Calcineurin inhibitor
What is the treatment for minimal change disease?
Steroids (PO)
What condition should be considered for minimal change disease minimally responsive to steroids?
FSGS
At what eGFR is immunosuppression no longer warranted for IgA nephropathy?
eGFR < 30
What UPCR should an ACEi/ARB be started for IgA nephropathy?
UPCR > 0.5 grams/d
