Nephrology

Question 1

What are the indications of using alternative to steroid therapies in NS patient?

Answer 1

steroid dependent patients
frequent relapses
steroid – resistant patients.

Question 2

What are the S/E of cyclophosphamide?

Answer 2

Neutropenia.
Disseminated varicella.
Hemorrhagic cystitis.
Alopecia.
Sterility.
Increase of future malignancy.

Question 3

How is cyclophosphamide given?

Answer 3

2mg/kg daily single dose for 8-12 weeks associated with continuing the alternate day prednisolone.

Question 4

How to monitor s/e of cyclophosphamide?

Answer 4

By weekly WBC measurements and it should be stopped if WBC fall below 5000/m3