Nephro Flashcards
Hematuria
Glomerular origin is suggested by
Dysmorphic erythrocytes
Anion gap is calculated as
AG= Na - ( CL + Hco3)
Delta-Delta ratio
= ( AG - 12 ) / ( 25 - HCO3)
Delta- delta ratio interpretation
< 1 ; + NAGMA
1-2 ; pure HAGMA
> 2 ; + metabolic alkalosis
Osmolar gap formula
= measured osmolality - calculated osmolality
Plasma osmolality is calculated by
( 2x Na ) + Glucose + urea
causes of Metabolic alkalosis
VALH
1. Vomiting
- Antacid use
- Loop diuretics
- Hyperaldosteronism
NAGMA causes
HARD ASS
1. hyperalimentation ( TPN)
- Addison disease
- RTA
- Diarrhea
- Acetazolamide
- Spironolactone
- Saline infusion
HAGMA causes
Renal: uremic acidosis when GFR < 15-20
Extrarenal :
Lactic acidosis
DKA
Starvation ketoacidosis
Alcoholic keto acidosis
Poisoning
Treatment of chronic HTN in pregnancy if BP
SBP >= 160 or DBP > =110
Treatment of Lithium induced DI
Amiloride
Ttt of RTA type 1
Potassium citrate
Ttt of RTA type 2
Bicarbonate + - thiazide
Ttt of RTA type 4
Correct the underlying cause
Thiazide or loop
Causes of Urine Cl< 15
Vomiting
Nasogastric suction
Diuretics
Urine cl > 15 + HTN + Hypo K
Cushing
1ry hyperaldosteronism
Urine cl > 15 + Hypo K without HTN
Bartter’s syndrome
Gitelman’s syndrome
Correction rate of hyper Na
=< 0.5 mmol/hr with goal correction of 10 -12 mmol / day
Ttt acute symptomatic isovolemic hypotonic hypo Na
100 ml bolus 3% saline to increase S.Na by 2-3 mmol/l
Correction Target of chronic symptomatic isovolemic hypotonic hypo Na
4-6 mmol /l over 24 hrs
Ttt osmotic demyelination syndrome
Desmontes sin & iv D5%w
Tolvaptan indicated in
S.Na < 120
Persistent SIADH that failed to water restriction
Tolvaptan contraindicated in
Hypovolemic or
Acute symptomatic hypo Na
Ttt of struvite stone
Treatment of the infection
Urological intervention
Ttt of uric acid stones
Acetazolamide
Allopurinol
Ttt of cystine kidney stones
Acetazolamide
Penicillamine
Tiopronin
Chronic HTN in pregnancy
Before 20 weeks of gestation
Gestational HTN
After 20 weeks of gestation
Treatment of HTN in pregnancy to maintain BP
BP < 140/90
Anti HTN drugs in pregnancy
Methyldopa
Labetalol
CCB
Salicylate toxicity treatment
Iv NaHco3
Goal of urine PH > 7.5 And Serum PH 7.5 - 7.55 is essential to avoid CNS accumulation of salicylic acid in the brain
Ttt of TLS to rapidly reduce serum urate level
Rasburicase