Nephritic syndrome - Rapidly progressive Glomerulonephritis

Question 1

What characterizes Rapidly progressive Glomerulonephritis?

Answer 1

Nephritic syndrome with rapid loss of renal function, oliguria and if untreated death in weeks or months.

Question 2

What is the characteristic histology of Rapidly progressive Glomerulonephritis?

Answer 2

Underlight microscopy the presence of crescents in Bowman space.

Question 3

What makes up these crescents?

Answer 3

Proliferating parietal epithelial cells, macrophages and fibrin eventually with areas of necrosis.

Question 4

What type of deposits are present in Type I Rapidly progressive Glomerulonephritis

Answer 4

Linear deposits (usually anti-GBM) can only be visualized by IF

Question 5

What kind of deposits are present in TYPE II Rapidly progressive Glomerulonephritis?

Answer 5

Granular
Usually immune complex diseases
lumpy bumpy pattern in the GBM and mesangial matrix

Question 6

What type of deposits are in Type III Rapidly progressive Glomerulonephritis?

Answer 6

None. Tye III is defined by the presence of crescents without significant immunoglobulin or complement deposits detectable by either EM or IF.

Question 7

What are the causes of Type III?

Answer 7

1.C-ANCA
2.P-ANCA
3.

Question 8

What C-ANCA wegner’s what other involvement would you expect the patient to have?

Answer 8

Granulomatous vasculitis in 3 places

• Kidney
• Lung
• URI (Nose, mouth and throat)