Calcium and phosphate metabolism Flashcards
What is the increase in risk rate for CVD in patients with stage 5 kidney disease?
10-20 times greater.
What happens in terms of coronary artery calcification in dialyses patients
Rate of calcification increased
Where is the majority of phosphorus in the body?
1.Bone
followed by
-Soft tissue
-Extracellular fluid
Where is the majority of phosphorus reabsorbed?
Proximal tubule reabsorbs in the PCT (80%)
What transporter is responsible for reabsorption of phosphate?
NaPi aka the sodium phosphate transporter
P excretion is?
Proportional to GFR and Serum Phosphorus levels
What is the effect of PTH on Phosphorus levels
It limits phosphorus reabsorption and causes increase levels of phosphorus in the urine
PTH effect on Phosphorus in the intestinal lumen?
Increases absorption
What is the effect of PTH on phosphorus in bone?
Releases more in the blood stream
What effect does PTH on vitamin D?
Increases Vit D synthesis
What is the GFR rate at which the body is no longer able to maitain phosphorus balance?
GFR >40
What is the effect of Vit D on Calcium absorption?
Increases it in the gut.
How is the majority of Calciu in the serum?
Bound to Albumin
Is the Ca2+ bound to Albumin active?
No, only the free ionized calcium is active.
With Advancing kidney disease is it more likely to develop hyper or hypo calcemia?
Both.
