Neoplasms

Question 1

What do angiosarcomas stain positive for?

Answer 1

Cd31, cd34, ERG, FLI-1+

Question 2

What immunostain differentiates atypical vascular lesion and radiation induced angiosarcoma?

Answer 2

C-MYC POSITIVE IN ANGIOSARCOMA

Question 3

Keratin mutation in white sponge Nevus?

Answer 3

Keratin 4/13

Question 4

What immunostain do we use for kaposi ?

Answer 4

Latency associated nuclear antigen

LANA-1

Question 5

What margins do you need for imiquimod?

Answer 5

Max 2cm with a 1cm margin

Question 6

What is Linear focal elastosis? What does it look like on H&E? What stains do you use?

Answer 6

Keloidal change of straie. Normal-appearing epidermis with abundant dermal deposits of abnormal, wavy, pale-staining elastic fibers with feathered ends. Verhoeff–Van Gieson stain positive for aggregated elastic fibers, but Von Kossa negative for calcified elastic fibers (as would be seen in PXE).

Question 7

Anterior and posterior cervical hypertrichosis associations

Answer 7

Anterior associated with sensory

Posterior associated with spine problems

Question 8

Medications associated with depigmentation of hair root? Name 2

Answer 8

Sunitinib

Chloroquine

Question 9

What is pityriasis rotunda?

Answer 9

Rare disease characterised by round or oval scaly, pigmented patches that mainly occur on the trunk, arms and legs. When occuring in asians/blacks over the age of 40yo, it is associated with malignancy. (chronic myeloid leukaemia, squamous cell carcinoma, multiple myeloma), Liver disease, Tuberculosis, Cardiac disease, Pulmonary disease, Chronic renal failure
Nutritional disease