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My Pulmonary Boards > Neoplasm > Flashcards

Neoplasm Flashcards

1
Q

Squamous cell carcinoma associated with

A

Cavitation
Pancoast syndrome
Hypercalcemia

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2
Q

Squamous cell carcinoma immunohistochemistry

A

P63
Cytokeratin 5/6
TTF negative

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3
Q

Adenocarcinoma immunohistochemical stains

A

Thyroid transcription factor-1

Napsin A

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4
Q

Typical carcinoid treatment

A

Limited resection and lymph node dissection

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5
Q

Atypical carcinoid treatment

A

Lobe to my ad mediastinal lymph node dissection

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6
Q

Metastatic carcinoid treatment

A

No known benefit of chemotherapy or radiation

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7
Q

Small cell immunohistochemistry

A

Thyroid transcription factor-1
CD 56
Synaptophysin
Chromogranin

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8
Q

Inter group 0139 trial

A

IIIA/N2 disease no benefit from surgery after chemo/RT, can try lobectomy

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9
Q

Metastatic angiosarcoma pulmonary findings

A

Cystic > cavitation lesions, can extend to the subpleural space leading to spontaneous pneumothorax

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10
Q

Metastatic SCC pulmonary findings

A

Solid and cavitary lesions, NO cysts

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11
Q

t(11;19) (q21;p13)

A

Mucoepidermoid carcinoma

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12
Q

Cytarabine complications

A

Bone marrow suppression

Cerebellar ataxia in high doses

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13
Q

Daunorubicin and other anthracycline complications

A

Cardio toxicity

Promotion of secondary hematologic malignancies

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14
Q

Etoposide complications

A

Bone marrow suppression
Nausea and Vomiting
Can promote secondary malignancies

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15
Q

Bronchial granular cell tumors characteristics

A

Rare and mostly benign
commonly originate from tongue and skin
Tend to develop in 3rd and 4th decade

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16
Q

Bronchial granular cell tumor staining

A

S-100 protein
Vimentin
PAS

17
Q

Solitary fibrous tumor of the pleura markers

A

CD34
BCL2
CD99
Vimentin

18
Q

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) epidemiology

A

Women (92%)
Mean age 58-65
Nonsmokers

19
Q

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) diagnosis

A 
Cough, dyspnea, wheezing
Decreased DLCO and airflow limitation
CT showing mosaic attenuation, profuse subcentimeter nodules 
Requires surgical lung biopsy
Bronchoscope 20% yield
20
Q

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) pathology

A

Due to enhanced neuroendocrine cell hyperplasia and associated peptide secretion, peribronchial fibrosis and small airway obliteration occur c/w obliterating bronchiolitis

21
Q

Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) markers

A

Increased expression of markers of cell-cycle proliferation: Ki-67, p53, p16 = premalignant condition

22
Q

Hypervascular massess in middle mediastinum

A

Angiofollicular lymph node hyperplasia (Castleman’s disease)
Vascular malformations
Metastatic disease
Paragangliomas

23
Q

Hypervascular massess in anterior mediastinum

A

Ectopic parathyroid adenomas

Thymic carcinoids

24
Q

Hypervascular massess in posterior mediastinum

A

Neurogenic tumors

25
Q

Differentiation Syndrome symptoms

A 
AKA retinoids acid syndrome - can include:
Fever
Peripheral edema
Pulmonary infiltrates
Respiratory distress
Hypotension
Renal and hepatic dysfunction
Rash
Pleural and pericardial effusions
26
Q

Differentiation Syndrome cause

A

~ 25% patients with acute promyelocytic leukemia during induction therapy with all-trans retinoids acid (tretinoin) or arsenic trioxide

27
Q

Complications of tunneled pleural catheters

A

Infection < 5% (often responds to antibiotic treatment without catheter removal)
Plural loculations (can be improved with intrapleural fibrinolytic therapy)
Catheter displacement 1-3%
Tumor tracking .5-3% (usually mesothelioma)

28
Q

Rituximab description

A

Chimeric immunoglobulin G1 directed against CD20, targeting B cell lineages (pre-B cell through pre-plasma cell)

29
Q

Rituximab MOA

A

Induces antibody dependent, cell mediated lysis

30
Q

Rituximab complications

A

Hypogammaglobulinemia in certain population

Possible altered T-cell immunity (not lymphopenia)

My Pulmonary Boards (6 decks)

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