neoplasm Flashcards
A 65-year-old right-handed woman began having neurological prob-
lems about 1 week ago. She began experiencing nausea, vomiting, and
numbness in the left hand and left foot. Today she had a generalized con-
vulsion, and since then she has had a throbbing headache that is worse
when she bends forward. On examination, the only deficits she has are loss
of double simultaneous tactile stimulation and left lower facial droop when
smiling. MRI reveals a lesion suggestive of a primary brain tumor.
The most common sources of primary brain tumors are
a. Glial cells
b. Neurons
c. Meningeal cells
d. Lymphocytes
e. Endothelial cells
The answer is a.( Bradley, p 1266.) Between 2 and 5% of all tumors
occurring in the general population are primary CNS tumors. In adults, the
most common primary brain tumor is the astrocytoma. In children, brain
tumors are more likely to arise in the posterior fossa. Even in childhood,
glial cell tumors, such as the cerebellar astrocytoma and the optic glioma,
are common
A 65-year-old right-handed woman began having neurological prob-
lems about 1 week ago. She began experiencing nausea, vomiting, and
numbness in the left hand and left foot. Today she had a generalized con-
vulsion, and since then she has had a throbbing headache that is worse
when she bends forward. On examination, the only deficits she has are loss
of double simultaneous tactile stimulation and left lower facial droop when
smiling. MRI reveals a lesion suggestive of a primary brain tumor.
The most common type of primary brain tumor is
a. Meningioma
b. Astrocytoma
c. Lymphosarcoma
d. Oligodendroglioma
e. Medulloblastoma
The answer is b. ( Bradley, p 1266.) The most common primary
brain tumors are malignant astrocytomas. These are classified as grade 3 or
4. Grade 4 astrocytoma is more commonly called glioblastoma multiforme.
It is malignant in the very conventional sense that it invades adjacent tis-sue. This type of glial tumor is usually seen in adults; men are more sus-ceptible than women
Most brain tumors in children are
a. Metastatic lesions from outside the central nervous system (CNS)
b. Oligodendrogliomas
c. Glioblastomas multiforme
d. Meningiomas
e. Infratentorial
The answer is e.( Bradley, p 1276.) The posterior fossa is the usual
location for brain tumors in children. Medulloblastomas, ependymomas,
and cerebellar (or brainstem) gliomas account for most of the tumors that
occur before puberty. Other common tumors developing intracranially in
children include optic gliomas and metastatic leukemias.
The incidence of primary brain tumors in children—about 1 to 5 per
100,000 per year—is mainly accounted for by
a. Meningiomas and neurofibromas
b. Astrocytomas and medulloblastomas
c. Melanomas and choriocarcinomas
d. Gliomas and adenomas
e. Colloid cysts of the third ventricle
The answer is b. ( Rowland, p 297.) Meningiomas may occur in
childhood but are more likely to appear and become symptomatic during
adult life. Neurofibromas are not primary brain tumors, although schwan-noma of the eighth cranial nerve is sometimes incorrectly referred to as an
acoustic neurofibroma rather than an acoustic schwannoma. Colloid cysts
of the third ventricle are not necessarily neoplastic, although most are
assumed to have started as neoplasms rather than as developmental anom-alies. Glioma is a broad category that includes the astrocytoma. Adenomas,
such as pituitary adenomas, do develop in children, but much less com-monly than either astrocytomas or medulloblastomas. Central nervous sys-tem tumors account for a large proportion of the tumors seen in childhood.
In fact, they are second in frequency only to childhood leukemias and
account for 15 to 20% of childhood tumors.
A 72-year-old woman has a head CT performed because of headaches.
It is significant for a left hemisphere mass with an overlying hyperostosis of
the skull. She most likely has which of the following?
a. Meningioma
b. Pituitary adenoma
c. Astrocytoma
d. Schwannoma
e. Hemangioblastoma
The answer is a.( Rowland, p 306.) Hyperostosis is thickening of the
bone and is much less commonly induced by tumors in or about the brain
than is thinning of the bone. Thinning occurs especially with pituitary ade-nomas, which may cause erosions in the floor of the sella turcica as an early
feature. Calcifications may develop in schwannomas or astrocytomas, but
both of these tumor types will usually cause bony erosions where they
impinge on the skull. Calcifications may develop in many primary or
metastatic brain tumors, but calcification sufficient to be readily seen on a
skull x-ray suggests an astrocytoma, meningioma, oligodendroglioma, or
metastatic tumor. Calcification can be visualized on CT scan in about 17%
of medulloblastomas. With meningiomas, hyperostosis may develop in the
bone adjacent to the tumor even if there is no infiltration of the bone by the
tumor
A 9-year-old girl with papilledema and precocious puberty is most likely to have a. A pineal region tumor b. An oligodendroglioma c. A Kernohan class II astrocytoma d. A brainstem glioma e. An ependymoma
The answer is a.( Rowland, p 343.) The pineal region is the source
of an extraordinarily diverse group of tumor types, ranging from astrocy-tomas (derived from glial tissue) to chemodectomas (derived from sympa-thetic nervous tissue). Several different types of germ cell tumors arise from
the tissues in this region, presumably from embryonal cell rests. In the
United States, pineal tumors account for only 1% of intracranial tumors,
but one-third of these pineal tumors are germ cell tumors, including ger-minomas and choriocarcinomas.
A 15-year-old boy has multiple angiomatoses of the retina and cysts of the kidney and pancreas. The brain tumor that is most likely to develop in this child is which of the following? a. Glioblastoma multiforme b. Meningioma c. Hemangioblastoma d. Ependymoma e. Pinealoma
The answer is c. ( Rowland, p 375.) With von Hippel-Lindau syn-drome, the patient may exhibit tumors in multiple organs. In the brain,
hemangioblastomas are the tumors most likely to arise, and these tumors
are usually limited to the cerebellum or brainstem. Hemangioblastomas are
often multiple and become symptomatic by bleeding into themselves. The
initial episode of bleeding may prove lethal.
A 56-year-old right-handed woman who had breast cancer 1 year
ago began having neurological problems about 1 week ago. She began
experiencing nausea, vomiting, and numbness in the right hand and foot.
Today she is experiencing crescendo pain in the left retroorbital area. Her
headache is throbbing and positional, particularly when she tries to bend
forward. The headache was intense in the morning, and at times it woke
her up last night. On examination, the only deficits are loss of double
simultaneous tactile stimulation and right lower facial droop when smiling.
The most appropriate next action would be to
a. Administer intravenous prochlorperazine
b. Give the patient a prescription for zolmitriptan
c. Make a follow-up appointment for next month
d. Order an electroencephalogram to rule out seizures
e. Get a brain MRI
The answer is e. ( Victor, pp 658–660, 684–686.) The headache is
typical of that caused by intracranial hypertension. Additionally, the
patient has focal neurological symptoms and signs. This creates particular
concern about a brain tumor or hemorrhage, and the patient should be
evaluated as soon as possible. An appointment next month is too late.
Intravenous prochlorperazine is a good treatment for status migrainosus;
however, this history is atypical for such a diagnosis and more serious
problems should be ruled out first in the emergency room. Zolmitriptan is a treatment for migraines. This history is not typical for migraine, and
zolmitriptan is also relatively contraindicated in patients with complex
migraine. This history is very atypical for seizures, and an electroen-cephalogram is not likely to provide useful information in this case
A 56-year-old right-handed woman who had breast cancer 1 year
ago began having neurological problems about 1 week ago. She began
experiencing nausea, vomiting, and numbness in the right hand and foot.
Today she is experiencing crescendo pain in the left retroorbital area. Her
headache is throbbing and positional, particularly when she tries to bend
forward. The headache was intense in the morning, and at times it woke
her up last night. On examination, the only deficits are loss of double
simultaneous tactile stimulation and right lower facial droop when smiling.
Further evaluation reveals multiple brain masses. The most common
source of metastatic tumors to the brain is the
a. Breast
b. Lung
c. Kidney
d. Skin
e. Uterus
The answer is b.(Osborn, p 660.) The breast, lung, kidney, skin, and
uterus are all common sources of metastases to the brain. The incidences of
metastases from the lung and breast in women are very close, but with the
climbing rates of pulmonary carcinoma in women, the lung has become
the more common source. Skin lesions metastasizing to the brain include
malignant melanomas
A 56-year-old right-handed woman who had breast cancer 1 year
ago began having neurological problems about 1 week ago. She began
experiencing nausea, vomiting, and numbness in the right hand and foot.
Today she is experiencing crescendo pain in the left retroorbital area. Her
headache is throbbing and positional, particularly when she tries to bend
forward. The headache was intense in the morning, and at times it woke
her up last night. On examination, the only deficits are loss of double
simultaneous tactile stimulation and right lower facial droop when smiling.
Metastatic lesions to the brain most often appear
a. At the gray-white junction
b. In the thalamus
c. In the posterior fossa
d. In the caudate
e. In the sella turcica
The answer is a.(Osborn, pp 660–661.) Metastatic lesions are spread
primarily by the vascular system. The gray-white junction (where the white
matter and the gray matter meet) is the interface at which blood-borne cells
are most likely to lodge and grow. No part of the brain is exempt from the
spread of metastases, but the cerebral hemispheres and the cerebellum are
especially vulnerable
A 56-year-old right-handed woman who had breast cancer 1 year
ago began having neurological problems about 1 week ago. She began
experiencing nausea, vomiting, and numbness in the right hand and foot.
Today she is experiencing crescendo pain in the left retroorbital area. Her
headache is throbbing and positional, particularly when she tries to bend
forward. The headache was intense in the morning, and at times it woke
her up last night. On examination, the only deficits are loss of double
simultaneous tactile stimulation and right lower facial droop when smiling.
The shortest life expectancy with metastatic disease to the brain will
be found in the patient with metastatic
a. Malignant melanoma
b. Breast cancer
c. Lung cancer
d. Renal cancer
e. Prostate cancer
he answer is a.( Victor, pp 697–699.) The outlook with malignant
melanoma, breast cancer, lung cancer, or renal cancer metastatic to the
brain is poor and limited to a matter of months, but malignant melanoma
is especially grim because it is highly likely to bleed after it metastisizes to
the brain. Malignant melanoma and choriocarcinoma are likely to produce
lethal intracranial hemorrhages, and the former may in fact first become
apparent only after it has precipitated an intracranial hemorrhage. Prostate
cancer does not typically metastasize to the brain
A 65-year-old right-handed woman began having neurological prob-
lems about 1 week ago. She began experiencing nausea, vomiting, and
numbness in the left hand and left foot. Today she had a generalized con-
vulsion, and since then she has had a throbbing headache that is worse
when she bends forward. On examination, the only deficits she has are loss
of double simultaneous tactile stimulation and left lower facial droop when
smiling. MRI reveals a lesion suggestive of a primary brain tumor.
The most common sources of primary brain tumors are
a. Glial cells
b. Neurons
c. Meningeal cells
d. Lymphocytes
e. Endothelial cells
The answer is a.( Bradley, p 1266.) Between 2 and 5% of all tumors
occurring in the general population are primary CNS tumors. In adults, the
most common primary brain tumor is the astrocytoma. In children, brain
tumors are more likely to arise in the posterior fossa. Even in childhood,
glial cell tumors, such as the cerebellar astrocytoma and the optic glioma,
are common
A patient has a MRI performed and a colloid cyst of the third ventri-cle is identified. The most common complication of this lesion is
a. Bitemporal hemianopsia
b. Hydrocephalus
c. Gait ataxia
d. Optic atrophy
e. Oscillopsia
The answer is b. ( Victor, pp 708–709.) Colloid cysts may produce
transient or persistent obstruction of the flow of CSF. Because this is an
especially deep-seated lesion, it may be more practical to simply shunt the
fluid from the lateral ventricles rather than attempt to excise the cyst.
These cysts are usually lined with epithelial cells and may arise from a
variety of sources, including low-grade neoplasms that involute early in
their evolution
The tumor type that is common in the brain of patients with AIDS, but otherwise extremely rare, is a. Lymphocytic leukemia b. Metastatic lymphoma c. Primary lymphoma d. Kaposi’s sarcoma e. Lymphosarcoma
The answer is c. ( Victor, pp 693–696.) Kaposi’s sarcoma is unusu-ally common in patients with AIDS, but it is rarely metastatic to the brain.Metastatic lymphomas producing meningeal lymphomatosis are not espe-
cially rare in the general population, but primary lymphomas (that is,
lymphomas apparently arising in the CNS) were rare before the AIDS epi-
demic. The primary brain lymphoma usually presents as a solitary mass
and can occur anywhere in the brain, but it does have a predilection for
the periventricular structures.
A 37-year-old man presents with visual impairment. Examination reveals a bitemporal hemianopsia. Which of the following tumors is most likely responsible for this finding? a. Optic glioma b. Occipital astrocytoma c. Brainstem glioma d. Pituitary adenoma e. Sphenoid wing meningioma
The answer is d.( Victor, p 714.) With bitemporal hemianopsia, the
visual fields in both eyes are impaired, but only the temporal quadrants of
the field in each eye are affected. Pressure on the optic chiasm inferiorly by
a tumor arising in or near the sella turcica will crush the fibers crossing in
the chiasm from the medial aspects of the optic nerves. The most medial
fibers in both optic nerves are contributed by the nasal aspects of the
retina. The nasal or medial aspects of the retina receive light from the tem-poral or lateral aspects of the visual field.