Neoplasia pathogenesis

Question 1

What is a Neoplasia?

Answer 1

• A Growth comprised of transformed cells
  
  • Cells are genetically altered
  • No longer behave normally
• Clinical significance varies from none to fata

Question 2

What causes neoplasia?

Answer 2

• mutation and transformation into a neoplastic cell can occur form a wide variety of insults
• Causes include:
  
  • inherited
  • Chemical exposure
  • Infectious agents
  • Physical agents

Question 3

How do infectious agents cause neoplasia?

Answer 3

• Viruses are notable causes of neoplasia
  
  • Can directly incorporate oncogenes into a cell
  • Can activate endogenous oncogenes
  • Can suppress host responses against neoplastic cells

Question 4

Where are the DNA damage checkpoints for the cell cycle?

Answer 4

• GS, S, G2/M
• arrest cell cycle when DNA damage is present

Question 5

Where is the DNA replication checkpoint in the cell cycle?

Answer 5

• G2/M
• Arrests cell cycle until DNA replication is complete

Question 6

What is the spindle checkpoint?

Answer 6

• Located at M stage
• Arrests cell cycle until al chromosomes are aligned