Neoplasia- carcinogens and associated cancers

Question 1

Aflatoxins

Answer 1

hepatocellular carcinoma

derived from aspergillus, stored rice and grains

Question 2

Alkylating agents

Answer 2

leukemia/lymphoma

side effect of chemo

Question 3

Alcohol

Answer 3

squamous cell carcinoma of oropharynx and upper esophagus, hepatocellular carcinoma

Question 4

Arsenic

Answer 4

squamous cell caricnoma of the skin, lung, angiosarcoma liver

Question 5

Asbestos

Answer 5

lung carcinoma and mesothelioma

HIGHER risk of lung cancer

Question 6

Cigarette Smoke

Answer 6

carcinoma of oropharynx, esophagus, lung, kidney, bladder, pancreas
most common worldwide
polycyclic hydrocarbons are the worst

Question 7

Nitrosamines

Answer 7

stomach carcinoma

Japan, smoked foods

Question 8

Naphthylamine

Answer 8

urothelial carcinoma of the bladder

from cigarette smoke

Question 9

Vinyl chloride

Answer 9

angiosarcoma of the liver

occupational exposure, used for pipes (PVC)

Question 10

Nickel, chromium, beryllium, silica

Answer 10

lung carcinoma, occupational

Question 11

EBV

Answer 11

nasopharyngeal carcinoma- Chinese male, Africans
presents as neck mass
Burkitt lymphona, CNS lymphoma in AIDS

Question 12

HHV-8

Answer 12

Kaposi sarcoma- tumor of endothelial cells, purple lesions on skin
E. European males, AIDS, transplant pt

Question 13

HBV and HCV

Answer 13

hepatocelllar carcinoma

Question 14

HTLV1

Answer 14

Adult T-cell leukemia/lymphoma

Question 15

High risk HPV- 16, 18, 31, 33

Answer 15

squamous cell carcinoma of the vulva, vagina, anus, and cervix, adenocarcincoma of cervic

Question 16

Ionizing radiation- nuclear, reactor accidents, radiotherapy

Answer 16

AML, CML, papillary carcinoma of the thyroid

generates OH- radicals

Question 17

Nonionizing radiation- UVB sunlight most common

Answer 17

basal cell carcinoma, squamous cell carcinoma, melanoma of skin
formation of pyrimidine dimers in DNA, normally excised by restriction endonuclease