Neoplasia

Question 1

What is this describing?

A state of autonomous cell division/proliferation in the absence of any continuing external stimulus.

Answer 1

Neoplasia

Question 2

What is this describing?
Division originating from a single cell which has acquired sufficient genomic alterations enabling it to divide autonomously.

Answer 2

Clonal proliferation

Question 3

What is this describing?

An abnormal mass of tissue showing uncoordinated growth and serving no useful purpose. Can be benign or malignant.

Answer 3

Neoplasm

Question 4

What is the behaviour and macroscopic appearance of a benign neoplasia?

Answer 4

1. Slow growing
2. Well circumscribed
3. Encapsulated by a layer of fibrous tissue
4. Not locally invasive
5. No metastatic potential

Question 5

What is the appearance and macroscopic appearance of a malignant neoplasia?

Answer 5

1. Fast growing
2. Poorly circumscribed
3. Non-encapsulated
4. Invasive growth
5. Metastatic potential

Question 6

What are the microscopic appearances of a benign neoplasia?

Answer 6

1. Tumour cells very closely resemble cell of origin (well differentiated).
2. Cells are uniform throughout the tumour
3. Few mitoses
4. Tumour cells have a normal nuclear:cytoplasmic ratio

Question 7

What are the microscopic appearances of of a malignant neoplasia?

Answer 7

1. May or may not closely resemble cell of origin (variable differentiation)
2. Cells and nuclei vary in shape and size (pleomorphic)
3. May mitoses
4. High nuclear:cytoplasmic ratio