Neil Keddie- Lecture 5 Nucleophilic Substitution 4 Flashcards by Edward Duffy | Brainscape

Q

What makes a good nucleophile?

A

Complex many factors

+ Anions that are conjugate bases of weak acids
+ Lower down the periodic table (LUMO and HOMO closer in energy)
These effects do not always match

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Q

What solvent favours SN1 substitution?

A

Polar protic solvent eg water or ethanol

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Q

What solvent favours SN2 substitution?

A

Polar aprotic solvents eg acetone

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Q

Match:
Good LG Excellent LG

A

SN1 SN2

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Q

Match:
Weak nucleophile Strong nucleophile

A

SN1 SN2

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