Neck lumps pathology Flashcards

1
Q

What is a branchial cyst?

A

-Original theory: branchial pouch remnant
-Now: Stratified squamous incorporated into cervical lymph tissue

Originally thought to be a branchial pouch remnant
However, the general consensus has now changed and branchial cysts are thought to be
stratified squamous epithelium incorporated into cervical lymph tissue

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2
Q

Where are branchial cysts most commonly found?

A

-Anterior to upper 1/3rd of the sternocleidomastoid muscle (SCM)
-anterior triangle of the neck
-2% are bilateral

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3
Q

When do branchial cysts present?

A

Most commonly seen in the 2nd - 3rd decade of life

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4
Q

How would you describe branchial cyst?

A

-Firm, smooth swellings
-Can become infected

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5
Q

How would you investigate a patient with a branchial cyst?

A

Fine needle aspirate (FNA)
This can be carried out in the clinic or under ultrasound guidance
MRI / CT neck to assess the extent of the mass and its relationship to major vessels

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6
Q

Describe aspirate of branchial cyst

A

The aspirate is typically straw coloured and rich in cholesterol, although pus may be present
when infected

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7
Q

How would you treat a branchial cyst?

A

Excision. Not to be undertaken lightly!
This must be carried out when the cyst is not infected as this will increase the risk of rupture
and recurrence

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8
Q

The next patient has been referred as they have a midline neck swelling that moves when they
protrude their tongue
What is the diagnosis?

A

Thyroglossal cyst

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9
Q

What is a thryoglossal cyst?
When do they present?
How do they present?

A

-Remnant of thyroglossal duct
-Presents in 1st decade
-Elevate when tongue is protruded

It is a remnant of the thryoglossal duct which represents the embryological path of the thyroid gland from its origin at the base of the tongue (foramen caecum)

The thyroglossal duct is usually obliterated after the descent of the thyroid gland

40% present in 1st decade with mean age of presentation 4 years old. However, they can be
seen much later into adult life

They will elevate when the tongue is protruded due to the embryological origin at the base of the tongue

Can enlarge rapidly if become infected

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10
Q

Are thyroglossal cysts always found in the midline?

A

No.
80 - 90% are in the midline
They can lie anywhere from the chin to the 2nd tracheal ring and be slightly off the midline

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11
Q

What other diagnoses should you consider as differential for swelling in midline?

A

Dermoid cyst
Lymph node
Sebaceous cyst
Thyroid nodule

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12
Q

What is the name of the operation to excise a thyroglossal cyst?

A

Sistrunk’s procedure
The thyroglossal duct surrounds the body of the hyoid bone and it is removed along with the
cyst
If the hyoid bone is not removed then recurrence rate is > 80%

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13
Q

The excised thyroglossal cyst is sent for histology. What will the cyst contain?

A

Most likely lymphoid tissue

It may contain ectopic thyroid tissue and it is essential to fully investigate the lump prior to surgery as the cyst may be the only functioning thyroid tissue that a patient has.

Ultrasound is used to assess the mass but also to look for a normal thyroid gland

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14
Q

What is a dermoid cyst?

A

It is an epithelial lined cyst that lies deep to the skin
They can be:
Congenital: result from inclusion of the epidermis along fusion lines of skin dermatomes
or
Acquired: usually secondary to an injury and skin forced into a wound

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15
Q

What are the most common sites for congenital dermoid cyst?

A

Medial and lateral aspects of the eyebrows
Midline of nose
Midline of neck and trunk

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16
Q

How would you treat a dermoid cyst?

A

Excision but with caution as congenital dermoid cysts may communicate with deep structures
Therefore pre-operative imaging may be required

17
Q

What is a sebaceous cyst?

A

Epidermoid or pilar cyst

The term sebaceous cyst is not fully correct. Used to describe below:
The correct terminology is either:
An epidermoid cyst: cyst that arises from epidermis
73
or
A pilar cyst: cyst that arises from hair follicles

18
Q

What are the classical clinical features of sebaceous cyst?

A

Smooth lumps attached to the skin and therefore do not move independently
Often firm consistency
May have a punctum, that may discharge
Can be erythematous and painful when infected.

19
Q

What are the most common sites that sebaceous cysts occur?

A

Scalp
Face
Neck
Trunk

20
Q

What is the treatment for sebaceous cyst?

A

Most commonly excised with overlying skin as it contains a punctum

21
Q

What is a lipoma?

A

It is benign collection of fat cells that is typically found in the subcutaneous layer of skin

22
Q

What are the clinical features of a lipoma?

A

Soft and slightly mobile
Very slow growing
Most common sites are shoulders and trunk
They are not found on palms or soles

23
Q

What is the treatment of lipomas?

A

Often no treatment
or
Excision (often for cosmetic reasons)

24
Q

The next patient is an emergency referral from a GP with an acute left side submandibular
swelling

The swelling has arisen over the past 24 hours, it is warm, red and very painful. It was
preceded by 2 days of dental pain

What is the most likely diagnosis of this neck swelling?

A

Submandibular abscess secondary to a dental cause

25
How would you manage this patient with submandibular abscess?
-Assess floor of mouth for ludwig's angina -Perform fibreoptic nasoendoscopy to assess airway -OPG to check dentition -Start IV abx -Refer to maxfax Examine the oral cavity looking particularly for floor of mouth swelling as this means the airway is becoming compromised Perform a fibre optic nasendoscopy to assess the airway. Submandibular abscesses can very rapidly progress to Ludwig’s Angina If possible get an orthopantomogram (OPG) to assess the dentition Start IV antibiotics (based on local guidelines but most commonly amoxicillin and metronidazole) Refer urgently to Oral and Maxillofacial team on call
26
What is Ludwig’s angina?
-Cellulitis of soft tissues of neck and floor of mouth -Spreads throughout both submandibular spaces causing elevation + posterior displacement of tongue -Leads to airway obstruction -Mostly requires intra and extra oral drainage with removal of causative tooth -Can cause airway oedema necessitating surgical airway It is a clinical diagnosis of cellulitis of the soft tissues of the neck and floor of the mouth. Cellulitis spreads throughout both submandibular spaces causing elevation and posterior displacement of the tongue. This leads to airway obstruction. Dental causes account for > 90% of cases The majority of cases require intra & extra oral incision and drainage with extraction of the causative tooth A small proportion of patients may require a surgical airway as intubation may not be possible due to airway oedema
27
What is a cystic hygroma?
-Congenital cystic malformation of lymphatic system -Most commonly in posterior triangle -Can rapidly enlarge if infected, can interfere with breathing/swalloign It is a congenital cystic malformation of the lymphatic system They can develop anywhere in the body but are most common found in the posterior triangle of the neck The majority are visible at birth and 90% are detected by 2 years of age Can rapidly enlarge when infected and this can interfere with breathing and swallowing
28
What is the treatment of cystic hygroma?
Aspiration and injection with a sclerosing agent or Surgical excision
29
What is a pharyngeal pouch?
-It is a diverticulum through Killian's dehiscence. -Killian’s dehiscence is found between the upper and lower portions of the inferior pharyngeal constrictor muscle
30
Describe the age of presentation and clinical features of a pharyngeal pouch.
Most common in males over 70 years of age Often no lump in the neck, occasionally a lump that gurgles may be noticed Patients often present with: regurgitation, halitosis, weight loss and chronic cough
31
How is a pharyngeal pouch investigated?
Barium swallow
32
How is a pharyngeal pouch treated?
If small and asymptomatic then no treatment is required However if treatment is required then either endoscopic stapling or external approach excision is performed
33
What general principles should be adhered to when examining and investigating a patient with a neck lump?
Full ENT exam including fibre optic nasendoscopy --> FNA or core biopsy (US guided if necessary) --> further imaging All patients require a full Ear, Nose and Throat examination including direct (fibre optic nasendoscopy) or indirect laryngoscopy (mirror) If it is safe and with appropriate experience then either an fine needle aspirate (FNA) or core biopsy should be taken in clinic to aid diagnosis If this is not possible then an FNA can be carried out under ultrasound guidance If there is a strong suspicion of malignancy many clinicians will also arrange appropriate imaging before a tissue diagnosis is made In summary: History --> Full ENT examination --> FNA --> Further imaging
34
Differential diagnosis of a neck lump?
Superficial: Sebaceous cyst Lipoma Abscess Anterior triangle: -Thyroglossal cyst -Thyroid swelling -Dermoid cyst -Submandibular gland pathology -Branchial cyst -Carotid body tumour -Lymphadenopathy Posterior triangle: -Pharyngeal pouch -Cystic hygroma -Lymphadenopathy Within SCM: Sternocleidomastoid tumor