NBME-3 Flashcards
Which is the most likely mediator released from macrophages that initated the process of septic shock?
Tumor necrosis factor
Pt has biopsy that shows small cell, neuroendocrine lung carcinoma. Which of the following abnormalities is most likely to develop in this patient?
- Hypocalcemia
- Hypoglycemia
- Hyponatremia
- Polycythmeia
- Hypocalcemia
- Hypoglycemia
- Hyponatremia
- Polycythmeia
Epidermal growth factor receptor and the platelet derived growth factor receptor are both classifered as which?
Receptor tyrosine kinases
HIV pt taking 2 different reverse transcriptase inhibitors and protease inhibtor, whats the point of the protease inhibtor?
blocking the cleavage step in active virion production.
Which of teh following contaminants will be removed from a fluid passed through a 0.45 u filter?
- Herpes Simplex virus
- HIV protease
- Lipopolysaccharide
- Mycoplasma hominis
- S. aureus
- Herpes Simplex virus
- HIV protease
- Lipopolysaccharide
- Mycoplasma hominis
- S. aureus
malignant neoplasm in the wall of the sigmoid colon, which group of lymph nodes is the neoplasm most likely to metastasize initially?
inferior mesenteric
what agent will most specifically complement antibiotic therapy (gave a specific pt)?
G-CSF (granulocyte-colony stimulating factor)
an acute extensive bilateral lesion in the rectiular formation of the tegmentum of the midbrain is most likely to result in which of the following?
loss of consciousness
- loss of abduction
- lateral roation
- flexion of arm
- loss of flexion at the elbow
- loss of supination of the forearm
What division is the lesion located at?
division containing C5 & C6
which substances will most likely cause blindness?
formic acid
for treatment of a psychotic episode which drug will cause:
- fever and muscle rigidity
- increase serum creatine kinase
Haloperidol
Viremia is an essential feature of which infection?
Primary varicella infection
injury to the common perineal nerve will result in lack of what motion?
dorsiflexion of the foot
pt has asthma and decreasing the severity of the episodes is done by inhibition of which enzyme?
5-Lipoxygenase
What will you find 3 months later, after someone (with dysphagia and odynophagia) ingests a drain cleaner containing sodium hydroxide?
Esophageal stricture
Pressure within the bladder increases in respose to what nervous system input?
Parasympathetic outflow from the sacral spinal cord.
an alcoholic man is found unresponsive after he drank large amounts of alcohol w/o eating any food over a 3 day period. His serum glucose concentration is 30 mg/dL.
This lab finding is most likely due to increased hepatic concentrations of which enzyme?
NADH
cultured cells are treated with an experimental agent that leads to rapid increases in cytoplasmic calcium concentrations and an increase in cellular diacylglyceral concentration. this experiement agent most likely stimulates which of the following?
- Adenylyl cyclase
- GTPase-activating protein
- Phospholipase C
- Protein Kinase A
- Protein Kinase C
- Adenylyl cyclase
- GTPase-activating protein
- Phospholipase C
- Protein Kinase A
- Protein Kinase C
A gel pattern obtain that is seen in southern blotting ( which is used to distinguish maternal and paternal copies of chromosome 7 in a single person).
Restriction fragment length polymorphism
A neoplasm in the colon invades through the basement membrane into the lamina propria. Which of the following proteins is most likely to be directly invovled in the process of invasion?
- APC gene product
- p53 protein
- ras gene product
- Rb gene product
- Type IV collagenase
- APC gene product
- p53 protein
- ras gene product
- Rb gene product
- Type IV collagenase
what is the rationale for advising a decrease in dietary intake of sodium chloride in patients with hepatict disease who develop edema?
Secondary hyperaldosteronism is present
What is the medication fro a pt that presents with 1 day of restlessness, irritability, and intense perirectal itching.
PHx: attends a lg day care facility, PE: perirectal region shows small worms that glow under bright light.
What is MOA and interaction
- Mebendazole
- MOA: inhibits the synthesis of microtubules in parasites and inhibits uptake of nutrients.
- Interactions: Carbamazapine and **phenytoin **lower levels of Mebendazole