Nausea and Vomiting

Question 1

What are the indications of cinnarizine?

Answer 1

Vertigo/menieres disease, nausea and vomiting, motion sickness and vestibular symptoms of other origins

Question 2

What are some targets of cinnarizine?

Answer 2

Histamine H1 receptor antagonist
Volatage-dependant L-type calcium antagonist
Volatge-dependant T-type calcium antagonist

Question 3

What is dimenhydranite?

Answer 3

An anti emetics drug combination that contains dimenhhydramine and theophylline

Question 4

What is dimenhydrinate used for?

Answer 4

Prevention and treatment of nausea, vomiting or vertigo of motion sickness

Question 5

Is dimenhydrinate effective in the treatment of nausea associated with cancer chemotherapy?

Answer 5

No

Question 6

What is the mechanism of action of dimenhydrinate?

Answer 6

Competitive antagonist at histamine H1 receptor

Question 7

What are some adverse effects of cinnarizine and dimenhydrinate?

Answer 7

drowsiness/somnolence, fatigue, parkinsonism, headache, abdominal pain, nausea and tremors

Question 8

What are some symptoms of overdose of cinnarizine and dimenhydrinate?

Answer 8

Delirium, hallucinations, excitement. Patients may be violent and confused

Question 9

What is dronabinol?

Answer 9

A synthetic form of delta-9-tetrahydrocannabinol which is the primary psychoactive component of cannabis

Question 10

What are the indications for dronabinol?

Answer 10

For anorexia associated weight loss in patients with AIDS, nausea and vomiting associated with cancer chemotherapy in patients who have failed to respond to conventional antiemetic treatments

Question 11

What is the MOA of dronabinol?

Answer 11

Weak partial agonist activity at the CB1R and CB2R receptors which results in the well-known effects of smoking cannabis

Inhibits endorphins in the emetic center, suppress prostaglandin synthesis, and/or inhibit activity through an unspecified cortical action