GERD Treatment Flashcards
Magnesium hydroxide can be used as
An antiacid and a laxative depending on tbe dose used
What is the mechanism of action of magnesium hydroxide?
Acts by simple neutralization of acid in the stomach
Is magnesium hydroxide metabolized in the stomach?
No, it is rapidly excreted in the urine
What are some common side effects of magnesium hydroxide?
Drowsiness and flushing (warmth, redness, tingly feeling)
Daily use of magnesium hydroxide can result in
Fluid and electrolyte disturbances
Magnesium hydroxide poisoning can result from
Hypermagnesemia
What are some symptoms of magnesium hydroxide poisoning?
Nausea, vomiting, flushing, thirst, hypotension, dowsiness, confusion, cardiac arrythmias (important), coma (important), cardiac arrest (important), respiratory depression, muscle weakness
Magnesium hydroxide is contraindicated in patients with
Kidney disease or renal failure, people with abdominal pain, myocardial damage, heart block, women who are about to deliver
Magnesium hydroxide can react with which drugs?
Digoxin, dicoumerol and cimetidine
What happens when ibuprofen is taken with magnesium hydroxide?
It can increase the absorption of ibuprofen
Magnesium hydroxide can decrease the absorption of which drugs?
Penicallamine, biphosphates, ketoconazole, quinolones, tetracycline
What type of tablets can be prematurely released when taken with magnesium hydroxide?
Enteric coated
What is the indication for cisapride?
For the symptomatic treatment of adult patients with nocturnal heartburn due to GERD
Cisapride is metabolized by the
Cytochrome P450 enzyme
What is an adverse effect of cisapride?
Long QT syndrome
