NASH Flashcards
1
Q
What is non-alcoholic steatohepatitis?
A
Fatty inflammatory changes to the liver, not associated with alcohol excess.
2
Q
Outline the spectrum of NAFLD
A
Non-alcoholic fatty liver- fatty changes to the liver, fully reversible, not associated with inflammation
NASH - fatty changes associated with inflammation and fibrosis, not fully reversible + may lead to cirrhosis
3
Q
What is the typical presentation of NASH?
A
Usually asymptomatic but MAY have hepatomegaly
4
Q
What are 4 common risk factors for NASH/
A
- Obesity
- Diabetes mellitus
- HTN
- Hyperlipidaemia
5
Q
How would you investigate NASH?
A
Bloods
o LFTs – generally hepatitic
o Lipid profile ↑
o BM ↑
USS abdo – snowstorm appearance
Biopsy – fat + inflammation
6
Q
How would you manage NASH?
A
- Weight loss
- Exercise
- Statins
- Diabetes control
- 6/12 USS and AFB to check for HCC development
7
Q
Complications of NASH
A
HCC
cirrhosis
